Correlation between BMI and metagenomics concentration of gut microbiota of college students in Inner Mongolia

XU Xinrui; WANG Xinyu; ZHANG Jing; GENG Yikun; BIAN Haodong; WU Yingxu; LIU Yanchao

doi:10.16835/j.cnki.1000-9817.2021.01.025

Volume 42 Issue 1

Apr. 2021

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2021 > 42(1): 106-108

XU Xinrui, WANG Xinyu, ZHANG Jing, GENG Yikun, BIAN Haodong, WU Yingxu, LIU Yanchao. Correlation between BMI and metagenomics concentration of gut microbiota of college students in Inner Mongolia[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(1): 106-108. doi: 10.16835/j.cnki.1000-9817.2021.01.025

Citation:

XU Xinrui, WANG Xinyu, ZHANG Jing, GENG Yikun, BIAN Haodong, WU Yingxu, LIU Yanchao. Correlation between BMI and metagenomics concentration of gut microbiota of college students in Inner Mongolia[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(1): 106-108. doi: 10.16835/j.cnki.1000-9817.2021.01.025

Citation:

XU Xinrui, WANG Xinyu, ZHANG Jing, GENG Yikun, BIAN Haodong, WU Yingxu, LIU Yanchao. Correlation between BMI and metagenomics concentration of gut microbiota of college students in Inner Mongolia[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(1): 106-108. doi: 10.16835/j.cnki.1000-9817.2021.01.025

PDF( 337 KB)

Correlation between BMI and metagenomics concentration of gut microbiota of college students in Inner Mongolia

doi: 10.16835/j.cnki.1000-9817.2021.01.025

1.
First Clinical Medical College, Inner Mongolia Medical University, Huhhot(010110), China

Received Date: 2020-06-17
Rev Recd Date: 2020-08-10

Available Online: 2021-04-01

Publish Date: 2021-01-25

Abstract

Abstract

Objective To explore the correlation between BMI and gut microbiota of college students in Inner Mongolia, and to provide a reference basis for revealing the relationship between intestinal flora and obesity. Methods Totally 88 college students from Inner Mongolia Medical University were enrolled, Height and weight were measured, and the feces samples were collected. The bacterial metagenome was extracted from dry feces samples for the concentration detection in per gram of dry feces, expressed as μg/μL. Correlation between BMI and metagenomics concentration of gut microbiota was statistically analyzed. Meanwhile, the metagenomics concentration of gut microbiota in different BMI groups was compared with each other. Results There was a negative correlation between BMI and the metagenomics concentration of gut microbiota(r=-0.27, P < 0.05). Significant difference in the concentration of gut microflora was observed between the normal group and the obesity group, the normal group and the overweight/obesity group(F=3.62, P < 0.05). Among the female volunteers, there were significant differences between normal group and overweight group, between normal group and obesity group(F=1.87, P < 0.05). No significant differences in metagenomics concentration of gut microbiota were found in different BMI groups(F=0.60, P>0.05) Conclusion There is a correlation between BMI and gut microbiota of college students in Inner Mongolia, the concentration of gut microflora metagenome in overweight and obese people decreased significantly.
- Body mass index,
- Gastrointestinal tract,
- Bacteria,
- Genes,
- Students

FullText(HTML)

References(18)

References

[1]	NCD Risk Factor Collaboration(NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2 416 population-based measurement studies in 128.9 million children, adolescents, and adults[J]. Lancet, 2017, 390: 2627-2642. DOI: 10.1016/s0140-6736(17)32129-3.
[2]	NCD Risk Factor Collaboration(NCD-Risc). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million purticipants[J]. Lacent, 2016, 387(10026): 1377-1396. http://www.ncbi.nlm.nih.gov/pubmed/27115820
[3]	CURETON K J, WARREN G L. Criterion-referenced standards for youth health-related fitness tests: a tutorial[J]. Res Q Exerc Sport, 1990, 61(1): 7-19. doi: 10.1080/02701367.1990.10607473
[4]	TURNBAUGH P J, LEY R E, MAHOWALD M A, et al. An obesity-associated gut microbiome with increased capacity for energy harvest[J]. Nature(London), 2006, 444(7122): 1027-1131. doi: 10.1038/nature05414
[5]	ZHAO L. The gut microbiota and obesity: from correlation to causality[J]. Nat Rev Microbiol, 2013, 11(9): 639. doi: 10.1038/nrmicro3089
[6]	LEY R E, CKHED B F, TURNBAUGH P, et al. Obesity alters gut microbial ecology[J]. Proc Natl Acad Sci USA, 2005, 102(31): 11070-11075. doi: 10.1073/pnas.0504978102
[7]	TURNBAUGH P J, CKHED B F, FULTON L, et al. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome[J]. Cell Host Microb, 2008, 3(4): 213-223. doi: 10.1016/j.chom.2008.02.015
[8]	CAESAR R, TREMAROLI V, KOVATCHEVA-DATCHARY P, et al. Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling[J]. Cell Metab, 2015, 22(4): 658-668. doi: 10.1016/j.cmet.2015.07.026
[9]	JAYASINGHE T N, CHIAVAROLI V, HOLLAND D J, et al. The new era of treatment for obesity and metabolic disorders: evidence and expectations for gut microbiome transplantation[J]. Front Cell Infect Microbiol, 2016, 6: 15. DOI: 10.3389/fcimb.2016.00015.
[10]	ECKBURG P B, BIK E M, BERNSTEIN C N, et al. Diversity of the human intestinal microbial flora[J]. Science, 2005, 308(5728): 1635-1638. doi: 10.1126/science.1110591
[11]	QIN J, LI R, RAES J, et al. A human gut microbial gene catalogue established by metagenom-ic sequencing[J]. Nature, 2010, 464(7285): 59-65. doi: 10.1038/nature08821
[12]	D'ARGENIO, VALERIA, FRANCESCO S. The role of the gut microbiome in the healthy adult status[J]. Clin Chim Acta, 2015, 451. DOI: 10.1016/j.cca.2015.01.003.
[13]	卫生部. 卫生部发布中国人胖瘦评判标准[J]. 质量探索, 2010(10): 21. Ministry of Health. The Ministry of Health released the criteria for weight status assessment[J]. Qual Explor, 2010(10): 21.
[14]	LE CHATELIER E, NIELSEN T, QIN J, et al. Richness of human gut microbiome correlates with metabolic markers[J]. Nature, 2013, 500(7464): 541-546. doi: 10.1038/nature12506
[15]	XIA H H, WANG J, CHEN X M, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention[J]. Nat Med, 2017, 23(7): 859-868. doi: 10.1038/nm.4358
[16]	刘艳超, 郝文利, 宿庄, 等. 自来水中细菌宏基因组DNA的浓度与细菌菌落总数的相关性分析[J]. 科学技术与工程, 2015, 15(32): 143-146. https://www.cnki.com.cn/Article/CJFDTOTAL-KXJS201532026.htm LIU Y C, HAO W L, SU Z, et al. The correlation between bacterial metagenomic DNA concentration and the total number of bacteria colonies in drinking water[J]. Sci Technol Eng, 2015, 15(32): 143-146. https://www.cnki.com.cn/Article/CJFDTOTAL-KXJS201532026.htm
[17]	DANIELSEN M. Effects of bacterial colonization on the porcine intestinal proteome[J]. J Prot Res, 2007, 6(3): 2596-2604. doi: 10.1021/pr070038b
[18]	王洋, 周礼红. 肥胖人群肠道菌群多样性研究[J]. 贵州大学学报(自然科学版), 2018, 35(4): 47-53. https://www.cnki.com.cn/Article/CJFDTOTAL-GZDI201804009.htm WANG Y, ZHOU L H. Study on intestinal bacterial diversity in obese people[J]. J Guizhou Univ(Nat Sci), 2018, 35(4): 47-53. https://www.cnki.com.cn/Article/CJFDTOTAL-GZDI201804009.htm