Regional feature in vitamin B12 related gene polymorphisms among minority students in primary and middle schools

Objective To analyze the regional feature vitamin B12-related gene polymorphisms in minority students, and to provide basic data for the relevant study. Methods This study collected 25 SNPs of the previous reports and the blood cell samples of 384 minority adolescents in the poor rural areas from Guangxi, Inner Mongolia and Xinjiang in 2016, DNA was extracted with immunomagnetic beads,Sequenom MassArray genotyping assay, and data results were analyzed by SPSS 16.0. Results The results showed that 11 SNPs were of statistically significant differences in the geographical distribution. The r2 were 1 between rs492602 and rs602662 on chromosome 19 for Uygur, Mongolian and Zhuang. The r2 between rs234706 and rs234713 on chromosome 21 was found imbalanced in the three areas. The r2 was 0.81 for students in Guangxi. Conclusion The study showed regional differences in vitamin B12 gene polymorphisms among minority adolescents.