Study on the association between sleeping status and impaired glucose tolerance among normal weight adolescents

Objective To explore the association between sleeping status and impaired glucose tolerance among normal weight adolescents,and to provide a reference for early prevention of related diseases caused by impaired glucose metabolism.Methods Based on the Chinese Metabolic Syndrome Cohort Study in Anhui province,412 boys and 317 girls of normal weight aged 12.6 to 18.9 years were taken as objects.And the related data was collected to analyze the correlation between sleeping characteristics,including sleep duration,sleep quality,and sleep disordered breathing (SDB) with fasting blood glucose level,impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).Results In the group of male adolescents of normal weight,a significantly positive correlation under fully adjusted model was found among age,BMI-Z,development stage,education on smoking and drinking,and the risk of PSQI,poor sleep quality,SDB with IGT probability [OR(95%CI) PSQI:1.449(1.158-1.813),P=0.012;PSQI ≥ 6:4.643(1.718-12.548),P =0.003;PSQI ≥ 5:4.737(1.898-11.827),P =0.001 SDB:2.972(1.010-8.746),P=0.048].In addition,sleep duration was negatively correlated with the probability of IGT[OR(95%CI) sleep duration:0.568(0.404-0.797),P=O.001;sleep duration<8 h:3.528(1.399-8.896),P=O.008].Conclusion The poor sleep quality and insufficient sleeping time could increase the risk of abnormal glucose tolerance among male adolescents of normal weight,but this trend is not obvious in the female group.