Relationship between concentration of vitamin D and parathyroid hormone among children in Guangzhou

Objective To understand the relationship of concentration of vitamin D and parathyroid hormone (PTH) of children in Guangzhou,providing early indicators for vitamin D deficiency.Methods Physical examination and laboratory tests were carried out among children in Guangzhou in a cross-sectional survey.Chemiluminescence was used to detect the levels of serum 25-hydroxy vitamin D 25(OH)D and PTH.Results The average serum 25(OH)D concentration was (90.67±36.55) nmol/L,there was no significant difference on serum 25 (OH) D concentration between boys and girls (P>0.05).The prevalence of vitamin D deficiency and insufficiency was 11.37% and 25.31%,respectively,no significant differences were found between boys and girls(P> 0.05).The serum 25(OH) D concentration related with age.With increase of age,the serum 25(OH) D concentration decreased(P <0.05),the prevalence of vitamin D deficiency and insufficiency increased (P<0.05).The average serum PHT concentration was (2.38± 1.29) pmol/L.The serum PTH concentration in vitamin D deficiency or insufficiency was higher than that in vitamin D sufficiency (P<0.05),negative correlation was found between 25 (OH) D and PTH (P<0.01).Conclusion The prevalence of vitamin D deficiency and insufficiency is high in children aged 3-16 years old in Guangzhou,serum 25(OH)D concentration negatively correlates with PTH.Comprehensive measures should be taken to improve the status of vitamin D of children.