儿童睡眠问题与口腔常见疾病关联的研究进展

赵彬彬; 孙莹; 陈新

doi:10.16835/j.cnki.1000-9817.2025216

儿童睡眠问题与口腔常见疾病关联的研究进展

doi: 10.16835/j.cnki.1000-9817.2025216

赵彬彬¹,
孙莹²,
陈新^1, ,

1.
安徽医科大学口腔医学院/安徽医科大学附属口腔医院/安徽省口腔疾病研究重点实验室，合肥 230032
2.
安徽医科大学公共卫生学院儿少卫生与妇幼保健学系

基金项目:

国家自然科学基金项目 82373591

安徽医科大学口腔医学院学科建设项目 2023xkfyts07

详细信息

作者简介:
赵彬彬(2001-)，女，陕西西安人，在读硕士，主要研究方向为儿童口腔健康

通讯作者:
陈新，E-mail: chenxinkq2672@126.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 Q428 R780.1
计量
- 文章访问数: 11
- HTML全文浏览量: 5
- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2025-04-27
- 修回日期: 2025-06-05
- 网络出版日期: 2025-08-02
- 刊出日期: 2025-07-25

Research progress on the association between childhood sleep disorders and common oral diseases

ZHAO Binbin¹,
SUN Ying²,
CHEN Xin^{1
, ,}

1.
College of Stomatology/Hospital of Stomatology, Anhui Medical University/Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, Anhui Province, China

摘要

摘要: 儿童睡眠问题与口腔常见疾病的关联已成为公共卫生领域的重要议题。研究综述了睡眠时长不足、睡眠相关疾病(如睡眠呼吸障碍、磨牙症)、“夜晚型”睡眠时型等多维度睡眠指标与儿童龋齿、牙周病、颌面发育异常等口腔相关疾病双向关联的流行病学证据，并探讨其潜在的神经生物学机制。提出未来需通过纵向队列研究和多组学技术进一步验证前瞻性因果关系，为儿童健康干预提供理论依据。
- 睡眠 /
- 口腔疾病 /
- 精神卫生 /
- 儿童
Abstract: The association of childhood sleep disorders and common oral diseases are increasingly recognized as public health challenges. The paper reviews epidemiological evidence on the bidirectional associations between multidimensional sleep indicators-including insufficient sleep duration, sleep-related disorders (sleep apnea and bruxism) and evening chronotype- and common oral diseases such as dental caries, periodontal diseases, and craniofacial developmental anomalies. It also explores potential neurobiological mechanisms underlying these associations. The review proposes that future research should employ longitudinal cohort studies and multi-omics technologies to further validate prospective causal relationships, thereby providing a theoretical foundation for developing childhood health interventions.
- Sleep /
- Mouth diseases /
- Mental health /
- Child
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

HTML全文

参考文献(45)

[1]	CHEN X, KE Z, CHEN Y, et al. The prevalence of sleep problems among children in mainland China: a Meta-analysis and systemic-analysis[J]. Sleep Med, 2021, 83: 248-255.
[2]	王兴. 第四次全国口腔健康流行病学调查报告[M]. 北京: 人民卫生出版社, 2018. WANG X. The fourth national oral health epidemiological survey[M]. Beijing: People's Medical Publishing House, 2018. (in Chinese)
[3]	SARDANA D, GALLAND B, WHEELER B J, et al. Effect of sleep on development of early childhood caries: a systematic review[J]. Eur Arch Paediatr Dent, 2023, 24: 1-14.
[4]	ZHOU N, ZHU H, CHEN Y, et al. Dental caries and associated factors in 3- to 5-year-old children in Zhejiang Province, China: an epidemiological survey[J]. BMC Oral Health, 2019, 19(1): 9.
[5]	OGAWA M, OGI H, NAKAMURA D, et al. Association between insufficient sleep and dental caries among preschoolers in Japan: a cross-sectional multicentre study[J]. Eur J Investig Health Psychol Educ, 2021, 12(1): 1-10.
[6]	MEHDIPOUR A, ABBASI R, KEYKHA E, et al. The association between dental caries, periodontal status, and sleep patterns in children[J]. Int J Clin Pediatr Dent, 2024, 17(8): 925-932.
[7]	AROUCHA L M C, AGUIAR D, PAIVA M, et al. Prevalence of sleep-disordered breathing and associations with malocclusion in children[J]. J Clin Sleep Med, 2020, 16(7): 1007-1012.
[8]	KIM K A, KIM S J, YOON A. Craniofacial anatomical determinants of pediatric sleep-disordered breathing: a comprehensive review[J]. J Prosthodont, 2025, 34(S1): 26-34.
[9]	ARROYO B A, RIBAS-PÉREZ D. Early childhood car-ies and sleep disorders[J]. J Clin Med, 2023, 12(4): 1378.
[10]	TAMASAS B, NELSON T, CHEN M. Oral health and oral health-related quality of life in children with obstructive sleep apnea[J]. J Clin Sleep Med, 2019, 15(3): 445-452.
[11]	DAVIDOVICH E, HEVRONI A, GADASSI L T, et al. Dental, oral pH, orthodontic and salivary values in children with obstructive sleep apnea[J]. Clin Oral Investig, 2022, 26(3): 2503-2511.
[12]	TOPALOGLU-AK A, KURTULMUS H, BASA S, et al. Can sleeping habits be associated with sleep bruxism, temporomandibular disorders and dental caries among children?[J]. Dent Med Probl, 2022, 59(4): 517-522.
[13]	LEE D W, KIM J G, YANG Y M. Influence of mouth breathing on atopic dermatitis risk and oral health in children: a population-based cross-sectional study[J]. J Dent Sci, 2021, 16(1): 178-185.
[14]	GENTRY N W, ASHBROOK L H, FU Y H, et al. Human circadian variations[J]. J Clin Invest, 2021, 131(16): e148282.
[15]	MAJEWSKA K, SEREMAK M, PODHORODECKA K, et al. New insights into health conditions related to malfunctions in clock genes[J]. Biomolecules, 2024, 14(10): 1282.
[16]	KURTOVIC A, TALAPKO J, BEKIC S, et al. The relationship between sleep, chronotype, and dental caries: a narrative review[J]. Clocks Sleep, 2023, 5(2): 295-312.
[17]	DA SILVEIRA K S R, PRADO I M, ABREU L G, et al. Association among chronotype, dietary behaviours, and caries experience in Brazilian adolescents: is there a behavioural pattern?[J]. Int J Paediatr Dent, 2018, 28: 608-615.
[18]	ALQADERI H, TAVARES M, AL-MULLA F, et al. Late bedtime and dental caries incidence in Kuwaiti children: a longitudinal multilevel analysis[J]. Commun Dent Oral Epidemiol, 2020, 48(3): 181-187.
[19]	FOLAYAN M O, EL TANTAWI M, OGINNI O, et al. Is chronotype profile a risk indicator for caries in children and adolescents in sub-urban Nigeria?[J]. Int J Paediatr Dent, 2021, 31(5): 627-633.
[20]	QUADRI M F A, ALWADANI M A, TALBI K M, et al. Exploring associations between oral health measures and oral health-impacted daily performances in 12-14-year-old schoolchildren[J]. BMC Oral Health, 2022, 22(1): 304.
[21]	ANGELHOFF C, FARESJÖ T, SUNDELL A L. Measuring hair cortisol concentration, insomnia symptoms and quality of life in preschool children with severe early childhood caries: a case-control pilot study[J]. Acta Odontol Scand, 2023, 81(7): 508-516.
[22]	VILLA M P, EVANGELISTI M, BARRETO M, et al. Short lingual frenulum as a risk factor for sleep-disordered breathing in school-age children[J]. Sleep Med, 2020, 66: 119-122.
[23]	HANSEN C, MARKSTRÖM A, SONNESEN L. Specific dento-crani-ofacial characteristics in non-syndromic children can predispose to sleep-disordered breathing[J]. Acta Paediatr, 2022, 111(3): 473-477.
[24]	LI Y, TONG X, WANG S, et al. Pediatric sleep-disordered breathing in Shanghai: characteristics, independent risk factors and its association with malocclusion[J]. BMC Oral Health, 2023, 23(1): 130.
[25]	BRUUN S N, HANSEN C, SONNESEN L. Sleepiness in children with severe malocclusion compared with in children with neutral occlusion[J]. Am J Orthod Dentofac Orthop, 2024, 165(5): 593-601.
[26]	SCHRADER L A, RONNEKLEIV-KELLY S M, HOGENESCH J B, et al. Circadian disruption, clock genes, and metabolic health[J]. J Clin Invest, 2024, 134(14): e170998.
[27]	FENG G, ZHAO J, PENG J, et al. Circadian clock: a promising scientific target in oral science[J]. Front Physiol, 2022, 13: 2388.
[28]	YU S, TANG Q, CHEN G, et al. Circadian rhythm modulates endochondral bone formation via MTR1/AMPKβ1/BMAL1 signaling axis[J]. Cell Death Differ, 2022, 29(4): 874-887.
[29]	LUO B, SONG J, ZHANG J, et al. The contribution of circadian clock to the biological processes[J]. Front Mol Biosci, 2024(11): 1387576.
[30]	HUANG W, HUANG Q, HE H, et al. PER2 promotes odontoblastic/osteogenic differentiation of dental pulp stem cells by modulating mitochondrial metabolism[J]. Int J Mol Sci, 2023, 24(13): 10661.
[31]	WU K, LI X, BAI Y, et al. The circadian clock in enamel development[J]. Int J Oral Sci, 2024, 16(1): 56.
[32]	SHANG Y F, SHEN Y Y, ZHANG M C, et al. Progress in salivary glands: endocrine glands with immune functions[J]. Front Endocrinol (Lausanne), 2023, 14: 1061235.
[33]	CIURLI A, MOHAMMED Y, AMMON C, et al. Spatially and temporally resolved metabolome of the human oral cavity[J]. iScience, 2024, 27(2): 108884.
[34]	GONZÁLEZ-GONZÁLEZ J M. Circadian rhythms and dental caries[J]. Int J Curr Res, 2018(10): 71616-71618.
[35]	MEHDIPOUR A, FATEH R, FULADVAND F, et al. Association between sleep pattern, salivary cariogenic bacteria and fungi populations, pH and buffering capacity in children: a comparative study[J]. Dent Med Probl, 2024, 61(2): 217-224.
[36]	TAKAYASU L, SUDA W, TAKANASHI K, et al. Circadian oscillations of microbial and functional composition in the human salivary microbiome[J]. DNA Res, 2017, 24(3): 261-270.
[37]	CHELLAPPA SL, ENGEN PA, NAQIB A, et al. Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota[J]. Faseb J, 2022, 36(1): e22043.
[38]	XUE Y, XU P, HU Y, et al. Stress systems exacerbate the inflammatory response after corneal abrasion in sleep-deprived mice via the IL-17 signaling pathway[J]. Mucosal Immunol, 2024, 17(3): 323-345.
[39]	CHEN P, WU H, YAO H, et al. Multi-omics analysis reveals the systematic relationship between oral homeostasis and chronic sleep deprivation in rats[J]. Front Immunol, 2022, 13: 847132.
[40]	ALARCÓN-SÁNCHEZ M A, BECERRA-RUIZ J S, AVETISYAN A, et al. Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and Meta-analysis[J]. BMC Oral Health, 2024, 24(1): 816.
[41]	NIE L, PAN X L, ZHANG X B, et al. Research on the correlation of immunity in patients with chronic insomnia[J]. Front Psychiatry, 2022, 13: 1034405.
[42]	YU X, JIANG H, CHENG G, et al. High levels of HIF-1α in hypoxic dental pulps associated with teeth with severe periodontitis[J]. J Mol Histol, 2020, 51(3): 265-275.
[43]	STANEK A, BRO YNA-TKACZYK K, MYSLINSKI W. Oxidative stress markers among obstructive sleep apnea patients[J]. Oxid Med Cell Longev, 2021, 2021: 9681595.
[44]	SEHIRLI A, CHUKWUNYERE U, AKSOY U, et al. The circadian clock gene Bmal1: role in COVID-19 and periodontitis[J]. Chronobiol Int, 2021, 38(6): 779-784.
[45]	ZHU R, MI X, LI Y. Effects of hypoxic environment on periodontal tissue through the ROS/TXNIP/NLRP3 inflammasome pathway[J]. Biomed Res Int, 2022, 2022: 7690960.