青少年血清谷丙转氨酶水平与颈动脉内中膜厚度的关联

黄思思; 赵敏; 孙嘉鸿; 席波

doi:10.16835/j.cnki.1000-9817.2025193

青少年血清谷丙转氨酶水平与颈动脉内中膜厚度的关联

doi: 10.16835/j.cnki.1000-9817.2025193

黄思思¹,
赵敏²,
孙嘉鸿^3, ,,
席波^1, ,

1.
山东大学齐鲁医学院公共卫生学院流行病学系/儿少卫生与妇幼保健学系/儿童心血管研究中心，济南 250012
2.
山东大学齐鲁医学院公共卫生学院营养与食品卫生学系
3.
广东医科大学公共卫生学院预防医学系

基金项目:

国家自然科学基金项目 81673195

国家自然科学基金项目 82173538

国家自然科学基金项目 82204066

山东省自然科学基金青年基金项目 ZR20210H272

详细信息

作者简介:
黄思思(2000-)，女，安徽淮北人，在读硕士，主要研究方向为儿童心血管健康

通讯作者:
孙嘉鸿，E-mail：jiahongsun1990@126.com

席波，E-mail：xibo2007@126.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R543.5 R446.11⁺²
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出版历程
- 收稿日期: 2025-05-07
- 修回日期: 2025-06-17
- 网络出版日期: 2025-08-02
- 刊出日期: 2025-07-25

Association between serum alanine transaminase levels and carotid intima-media thickness in adolescents

HUANG Sisi¹,
ZHAO Min²,
SUN Jiahong^{3
, ,},
XI Bo^{1
, ,}

1.
Department of Epidemiology/Maternal and Child Health/Children's Cardiovascular Research Centre, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China

摘要

摘要: 目的探讨青少年血清谷丙转氨酶(ALT)水平与颈动脉内中膜厚度(cIMT)的关系，为制定青少年心血管结构异常的早期防控策略提供依据。方法数据源于2023年10—11月开展的“桓台儿童心血管健康队列”第3次随访调查数据，共纳入1 153名具有完整信息的健康青少年。采用方差分析比较不同ALT水平组青少年的cIMT，采用多元线性回归分析血清ALT水平与cIMT的关系。结果 Q1，Q2，Q3 ALT水平组青少年的cIMT[(0.56±0.04)(0.57±0.04)(0.59±0.04)mm]差异有统计学意义(F=3.61，P < 0.01)。调整相关协变量后，多元线性回归分析结果显示，ALT水平与cIMT存在正相关(β=0.18，P < 0.01)。性别亚组分析结果显示，男生与总体结果相似(β=0.19，P < 0.01)，而女生中关联无统计学意义(β=0.07，P=0.54)。结论青少年血清ALT水平升高会增加血管结构损害的风险，在男生中尤为明显。及早发现并控制血清异常ALT水平有助于减少早期血管结构损害，降低不良心血管事件的发生风险。
- 谷氨酸转氨酶 /
- 颈动脉 /
- 血管中膜 /
- 回归分析 /
- 青少年
Abstract: Objective To investigate the relationship between serum alanine transaminase (ALT) and carotid intima-media thickness (cIMT) in adolescents, providing evidence for early prevention and control strategies for cardiovascular structural abnormalities in adolescents. Methods Data were obtained from the third follow-up survey (from October to November 2023) of the "Huantai Children Cardiovascular Health Cohort", including 1 153 healthy adolescents with complete information. Analysis of variance (ANOVA) was used to compare cIMT across different ALT level groups, and multiple linear regression was employed to analyze the relationship between serum ALT levels and cIMT. Results Significant differences in cIMT were observed among Q1, Q2, and Q3 ALT level groups [(0.56±0.04) (0.57±0.04) (0.59±0.04)mm, respectively; F=3.61, P < 0.01]. After adjusting for covariates, multiple linear regression revealed a positive correlation between ALT levels and cIMT (β=0.18, P < 0.01). Gender subgroup analysis showed similar results in males (β=0.19, P < 0.01), but no statistically significant association was found in females (β=0.07, P=0.54). Conclusions Elevated serum ALT levels are associated with an increased risk of vascular structural damage in adolescents, especially in boys. Early detection and control of abnormal serum ALT levels can help to reduce early vascular structural damage and further reduce the risk of adverse cardiovascular events.
- Alanine transaminase /
- Carotid arteries /
- Tunica media /
- Regression analysis /
- Adolescent
注释:

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表 1 不同性别学生基本特征比较(x±s)

Table 1. Comparison of basic characteristics of students in different genders(x±s)

性别	人数	年龄/岁	身高/cm	体重/kg	BMI/(kg·m^-2)	SBP/mmHg	DBP/mmHg	cIMT/mm	ALT/(U·L^-1)	每日睡眠时间/h
男	603	14.1±1.5	171.1±8.7	67.5±17.1	22.9±4.9	121.4±12.1	61.6±7.5	0.58±0.04	19.6±15.2	7.4±1.3
女	550	14.2±1.5	162.4±5.6	58.1±13.0	22.0±4.4	110.8±10.3	61.5±7.1	0.56±0.04	13.4±7.7	7.3±0.9
总计	1 153	14.1±1.5	167.0±8.5	63.0±16.0	22.4±4.7	116.4±12.5	61.6±7.3	0.57±0.04	16.6±12.6	7.4±1.1
t值		-0.45	20.45	10.56	3.41	16.00	0.13	9.82	8.81	0.98
P值		0.65	< 0.01	< 0.01	< 0.01	< 0.01	0.90	< 0.01	< 0.01	0.33

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表 2 不同性别学生人口学特征报告率情况

Table 2. Report of demographic basic characteristics of students in different genders

性别	人数	超重肥胖	视屏时间≥2 h/d	体力活动不足	蔬菜摄入不足	水果摄入不足	每周含糖饮料摄入≥1次	父亲过去或现在饮酒	母亲过去或现在饮酒
男	603	287(47.6)	98(16.2)	174(28.9)	551(91.4)	567(94.0)	155(25.7)	534(88.6)	218(36.2)
女	550	185(33.6)	66(12.0)	273(49.6)	529(96.2)	531(96.6)	88(16.0)	480(87.3)	234(42.5)
总计	1 153	472(40.9)	164(14.2)	447(38.7)	1 080(93.7)	1 098(95.2)	243(21.1)	1 014(87.9)	452(39.2)
χ²值		22.61	3.92	51.45	10.40	3.47	15.71	0.33	4.67
P值		< 0.01	0.05	< 0.01	< 0.01	0.06	< 0.01	0.56	0.03
注：()内数字为检出率或报告率/%。

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表 3 不同ALT组间青少年cIMT水平比较/mm

Table 3. Comparison of cIMT levels in adolescents among different ALT groups/mm

ALT分组	男生		女生		总体
ALT分组	人数	x±s	人数	x±s	人数	x±s
Q1	204	0.57±0.04	185	0.56±0.04	389	0.56±0.04
Q2	199	0.57±0.04	182	0.56±0.04	381	0.57±0.04
Q3	200	0.59±0.04^ab	183	0.57±0.04^a	383	0.59±0.04^ab
F值		47.63		23.44		3.61
P值		< 0.01		< 0.01		0.03
注：^a与Q1组比较，^b与Q2组比较，P < 0.05。

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表 4 青少年血清ALT水平与cIMT关联的多元线性回归分析

Table 4. Multiple linear regression analysis of the association between serum ALT levels and cIMT in adolescents

性别	模型1			模型2			模型3
性别	β值	标准误	P值	β值	标准误	P值	β值	标准误	P值
男(n=603)	0.48	0.07	< 0.01	0.23	0.07	< 0.01	0.19	0.07	< 0.01
女(n=550)	0.42	0.12	< 0.01	0.11	0.12	0.34	0.07	0.12	0.54
总体(n=1 153)	0.47	0.06	< 0.01	0.22	0.06	< 0.01	0.18	0.05	< 0.01
注：模型1调整性别、年龄；模型2在模型1基础上调整了体重状态、每日睡眠时间、体力活动水平、视屏时间、含糖饮料、蔬菜水果摄入、父/母饮酒状况；模型3在模型2基础上调整了SBP和DBP。

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