睡眠质量与青少年干眼症状的关联

谢佳煜; 李丹琳; 董兴璇; 开佳妍; 李娟; 吴一波; 潘臣炜

doi:10.16835/j.cnki.1000-9817.2025046

睡眠质量与青少年干眼症状的关联

doi: 10.16835/j.cnki.1000-9817.2025046

谢佳煜¹,
李丹琳¹,
董兴璇¹,
开佳妍¹,
李娟^2, ,,
吴一波^3, ,,
潘臣炜^1, ,

1.
苏州大学苏州医学院公共卫生学院，江苏 215123
2.
西安市人民医院(西安市第四医院)眼科
3.
北京大学公共卫生学院

基金项目:

南开大学眼科学研究院开放基金项目 NKYKD202206

详细信息

作者简介:
谢佳煜(2001-)，女，江苏常州人，在读硕士，主要研究方向为儿童青少年健康促进

通讯作者:
李娟，E-mail: cornea@163.com

吴一波，E-mail: bjmuwuyibo@outlook.com

潘臣炜，E-mail: pcwonly@gmail.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: B844.2 R591.41⁺² Q428
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- 被引次数: 0
出版历程
- 收稿日期: 2024-07-09
- 修回日期: 2024-11-17
- 网络出版日期: 2025-03-05
- 刊出日期: 2025-02-25

Association between sleep quality and dry eye symptoms among adolescents

XIE Jiayu¹,
LI Danlin¹,
DONG Xingxuan¹,
KAI Jiayan¹,
LI Juan^{2
, ,},
WU Yibo^{3
, ,},
PAN Chenwei^{1
, ,}

1.
School of Public Health, Suzhou Medical College of Soochow University, Suzhou (215123), Jiangsu Province, China

摘要

摘要: 目的探索青少年睡眠质量和干眼症状之间的关联，为降低青少年干眼症状患病率提供参考。方法研究对象为来自中国居民心理与行为调查(PBICR)的12~24岁青少年，于2022年6月20日—8月31日，采用分层随机与配额抽样相结合的方法在中国大陆范围选取6 456名青少年，并对其使用眼表疾病指数(OSDI)和简版匹兹堡睡眠质量指数(B-PSQI)评估干眼症状和睡眠质量。应用多元Logistic回归模型探索睡眠质量与青少年干眼症状之间的关系，利用交互项探讨性别对关联的影响。结果共有2 815名青少年报告存在干眼症状，报告率为43.6%。Logistic回归分析结果显示，睡眠质量不良的青少年干眼症状加重的风险增加，与睡眠质量良好组相比，睡眠质量不良组轻度、中度和重度干眼症状的OR值(95%CI)分别为1.39(1.16~1.67)，1.52(1.28~1.81)，2.35(2.02 ~2.72)(P值均 < 0.05)。睡眠质量和性别对青少年干眼症状的交互作用有统计学意义(P < 0.01)。结论睡眠质量与青少年干眼症状之间存在关联，睡眠质量不良者干眼症状加重的风险更高，其影响在男生中更大。
- 睡眠 /
- 干眼病 /
- 回归分析 /
- 青少年
Abstract: Objective To explore the association between sleep quality and dry eye symptoms in adolescents, so as to provide the evidence for reducing the prevalence of dry eye symptoms. Methods The study population was adolescents aged 12-24 years from the Psychology and Behavior Investigation of Chinese Residents (PBICR) survey, which was conducted from 20 June to 31 August 2022. A stratified random sampling and quota sampling method was used to select 6 456 adolescents within mainland China. The Ocular Surface Disease Index (OSDI) and Brief version of the Pittsburgh Sleep Quality Index (B-PSQI) were used to assess dry eye symptoms and sleep quality. Multiple Logistic regression model was used to explore the relationship between sleep quality and dry eye symptoms in adolescents. The influence of gender on the association was explored by using interaction terms. Results A total of 2 815 adolescents reported having dry eye symptoms, with a prevalence of 43.6%. Logistic regression analysis results showed an increased risk of exacerbation of dry eye symptoms in adolescents with poor sleep quality. The OR(95%CI) for mild, moderate, and severe dry eye symptoms groups were 1.39(1.16-1.67), 1.52(1.28-1.81), and 2.35(2.02-2.72), respectively, compared with the ocularly normal group (P < 0.05). There was a significant interaction between sleep quality and gender on dry eye symptoms in adolescents (P < 0.01). Conclusions Sleep quality is associated with dry eye symptoms in adolescents, and those with poor sleep quality have a higher risk of dry eye symptoms. The effect of sleep quality on dry eye symptoms is greater in boys.
- Sleep /
- Xerophthalmia /
- Regression analysis /
- Adolescent
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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图 1 性别和睡眠质量对青少年干眼症状的交互作用

Figure 1. Interaction of gender and sleep quality on dry eye symptoms in adolescents

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表 1 青少年不同程度干眼症状报告率单因素分析

Table 1. Univariate analysis of the report rates of different degrees of dry eye symptoms in adolescents

因素	选项	人数	轻度	中度	重度	χ²/H值	P值
年龄/岁	12~15	1 058	121(11.4)	96(9.1)	164(15.5)	22.92	< 0.01
	16~19	3 320	447(13.5)	405(12.2)	652(19.6)
	20~24	2 078	223(10.7)	305(14.7)	402(19.3)
性别	男	3 196	316(9.9)	377(11.8)	647(20.2)	33.64	< 0.01
	女	3 260	475(14.6)	429(13.2)	571(17.5)
眼科相关疾病	是	4 080	616(15.1)	546(13.4)	778(19.1)	74.98	< 0.01
	否	2 376	175(7.4)	260(10.9)	440(18.5)
慢性病	是	620	90(14.5)	110(17.7)	162(26.1)	11.58	< 0.01
	否	5 836	701(12.0)	696(11.9)	1 056(18.1)
易感疲劳	是	3 623	478(13.2)	518(14.3)	842(23.2)	681.74	< 0.01
	否	2 833	313(11.0)	288(10.2)	376(13.3)
平均每周参与体育活动天数/d	0~3	5 144	630(12.2)	641(12.5)	949(18.4)	19.01	< 0.01
	4~7	1 312	161(12.3)	165(12.6)	269(20.5)
平均每天入睡前使用智能手机时长/h	≤1	3 896	469(12.0)	478(12.3)	725(18.6)	1.63	0.65
	>1	2 560	322(12.6)	328(12.8)	493(19.3)
经济分区	东部	2 578	339(13.1)	312(12.1)	485(18.8)	4.26	0.64
	中部	2 184	247(11.3)	274(12.5)	412(18.9)
	西部	1 694	205(12.1)	220(13.0)	321(18.9)
睡眠质量	良好	4 687	556(11.9)	540(11.5)	669(14.3)	127.11	< 0.01
	不良	1 769	235(13.3)	266(15.0)	549(31.0)
注： ()内数字为报告率/%。

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表 2 睡眠质量与青少年干眼症状关联的多因素Logistic回归模型[OR值(95%CI)，n=6 456]

Table 2. Multivariate Logistic regression model for the association between sleep quality and dry eye symptoms in adolescents [OR(95%CI), n=6 456]

模型	睡眠质量	轻度	中度	重度
模型1	良好	1.00	1.00	1.00
	不良	1.72(1.45~2.04)	2.00(1.69~2.37)	3.34(2.90~3.83)
模型2	良好	1.00	1.00	1.00
	不良	1.39(1.16~1.67)	1.52(1.28~1.81)	2.35(2.02~2.72)
注： P值均＜0.01；模型1为未校正混杂因素，模型2为校正了性别、年龄、眼科相关疾病、慢性病、易感疲劳、平均每周参与体育活动天数等混杂因素。

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