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童年不良生活经历与心血管疾病关系的研究进展

雷雯淇 孙文杰 孙菁源 王艺儒 孙祥慧 邵金昂 马亚楠

雷雯淇, 孙文杰, 孙菁源, 王艺儒, 孙祥慧, 邵金昂, 马亚楠. 童年不良生活经历与心血管疾病关系的研究进展[J]. 中国学校卫生, 2025, 46(1): 148-152. doi: 10.16835/j.cnki.1000-9817.2025005
引用本文: 雷雯淇, 孙文杰, 孙菁源, 王艺儒, 孙祥慧, 邵金昂, 马亚楠. 童年不良生活经历与心血管疾病关系的研究进展[J]. 中国学校卫生, 2025, 46(1): 148-152. doi: 10.16835/j.cnki.1000-9817.2025005
LEI Wenqi, SUN Wenjie, SUN Jingyuan, WANG Yiru, SUN Xianghui, SHAO Jinang, MA Yanan. Research progress on the relationship between adverse childhood experiences and cardiovascular diseases[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(1): 148-152. doi: 10.16835/j.cnki.1000-9817.2025005
Citation: LEI Wenqi, SUN Wenjie, SUN Jingyuan, WANG Yiru, SUN Xianghui, SHAO Jinang, MA Yanan. Research progress on the relationship between adverse childhood experiences and cardiovascular diseases[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(1): 148-152. doi: 10.16835/j.cnki.1000-9817.2025005

童年不良生活经历与心血管疾病关系的研究进展

doi: 10.16835/j.cnki.1000-9817.2025005
基金项目: 

中国医科大学大学生创新创业训练计划资助项目 202310159025

详细信息
    作者简介:

    雷雯淇(2003-),女,山西省人,在读本科,主要研究方向为青少年慢性病及其影响因素

    通讯作者:

    马亚楠,E-mail: ynma@cmu.edu.cn

  • 利益冲突声明  所有作者声明无利益冲突。
  • 中图分类号: R179 R714.252 D432.7

Research progress on the relationship between adverse childhood experiences and cardiovascular diseases

  • 摘要: 为了解心血管疾病(CVD)与童年不良生活经历(ACEs)的关系,文章对CVD负担及影响因素、ACEs的流行病学现状及负担、ACEs与CVD关系的研究现状以及ACEs导致CVD的机制进行综述,提出需要找到血液标志物、开展前瞻性队列研究和干预研究等进一步评估二者之间的关系,为CVD的一级预防提供科学参考。
    1)  利益冲突声明  所有作者声明无利益冲突。
  • [1] ROTH G A, MENSAH G A, JOHNSON C O, et al. Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study[J]. J Am Coll Cardiol, 2020, 76(25): 2982-3021. doi: 10.1016/j.jacc.2020.11.010
    [2] ROTH G A, MENSAH G A, FUSTER V. The global burden of cardiovascular diseases and risks: a compass for global action[J]. J Am Coll Cardiol, 2020, 76(25): 2980-2981. doi: 10.1016/j.jacc.2020.11.021
    [3] OHIRA T, ISO H. Cardiovascular disease epidemiology in Asia: an overview[J]. Circ J, 2013, 77(7): 1646-1652. doi: 10.1253/circj.CJ-13-0702
    [4] National Center for Cardiovascular Diseases, the Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on cardiovascular health and diseases in China 2023: an updated summary[J]. Biomed Environ Sci, 2024, 37(9): 949-992.
    [5] TSAO C W, ADAY A W, ALMARZOOQ Z I, et al. Heart disease and stroke statistics-2023 update: a report from the American Heart Association[J]. Circulation, 2023, 147(8): e93-e621.
    [6] Blood Pressure Lowering Treatment Trialists' Collaboration. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data Meta-analysis[J]. Lancet, 2021, 397(10285): 1625-1636. doi: 10.1016/S0140-6736(21)00590-0
    [7] FUCHS F D, WHELTON P K. High blood pressure and cardiovascular disease[J]. Hypertension, 2020, 75(2): 285-292. doi: 10.1161/HYPERTENSIONAHA.119.14240
    [8] CHENG Y J, IMPERATORE G, GEISS L S, et al. Trends and disparities in cardiovascular mortality among U.S. adults with and without self-reported diabetes, 1988-2015[J]. Diabetes Care, 2018, 41(11): 2306-2315. doi: 10.2337/dc18-0831
    [9] ZHANG Y, PLETCHER M J, VITTINGHOFF E, et al. Association between cumulative low-density lipoprotein cholesterol exposure during young adulthood and middle age and risk of cardiovascular events[J]. JAMA Cardiol, 2021, 6(12): 1406-1413. doi: 10.1001/jamacardio.2021.3508
    [10] KIM M S, KIM W J, KHERA A V, et al. Association between adiposity and cardiovascular outcomes: an umbrella review and Meta-analysis of observational and Mendelian randomization studies[J]. Eur Heart J, 2021, 42(34): 3388-3403. doi: 10.1093/eurheartj/ehab454
    [11] LACROIX A Z, BELLETTIERE J, RILLAMAS-SUN E, et al. Association of light physical activity measured by accelerometry and incidence of coronary heart disease and cardiovascular disease in older women[J]. JAMA Netw Open, 2019, 2(3): e190419. doi: 10.1001/jamanetworkopen.2019.0419
    [12] MONS U, MüEZZINLER A, GELLERT C, et al. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium[J]. BMJ, 2015, 350: h1551. doi: 10.1136/bmj.h1551
    [13] BECERRA-TOMáS N, BLANCO MEJíA S, VIGUILIOUK E, et al. Mediterranean diet, cardiovascular disease and mortality in diabetes: a systematic review and Meta-analysis of prospective cohort studies and randomized clinical trials[J]. Crit Rev Food Sci Nutr, 2020, 60(7): 1207-1227. doi: 10.1080/10408398.2019.1565281
    [14] BENJAMIN E J, MUNTNER P, ALONSO A, et al. Heart disease and stroke statistics-2019 update: a report from the American Heart Association[J]. Circulation, 2019, 139(10): e56-e528.
    [15] BASU A, MCLAUGHLIN K A, MISRA S, et al. Childhood maltreatment and health impact: the examples of cardiovascular disease and type 2 diabetes mellitus in adults[J]. Clin Psychol (New York), 2017, 24(2): 125-139.
    [16] World Health Organization. Adverse childhood experiences international questionnaire(ACE-IQ)[EB/OL]. (2018-12-30)[2023-10-11]. http://www.who.int/violence_injury_prevention/violence/activities/adverse_childhood.
    [17] GERVIN D W, HOLLAND K M, OTTLEY P G, et al. Centers for disease control and prevention investments in adverse childhood experience prevention efforts[J]. Am J Prev Med, 2022, 62(6 Suppl 1): S1-S5.
    [18] PIERCE J B, KERSHAW K N, KIEFE C I, et al. Association of childhood psychosocial environment with 30-year cardiovascular disease incidence and mortality in middle age[J]. J Am Heart Assoc, 2020, 9(9): e015326. doi: 10.1161/JAHA.119.015326
    [19] JACQUET-SMAILOVIC M, BRENNSTUHL M J, TARQUINIO C L, et al. Relationship between cumulative adverse childhood experiences and myocardial infarction in adulthood: a systematic review and Meta-analysis[J]. J Child Adolesc Trauma, 2022, 15(3): 701-714. doi: 10.1007/s40653-021-00404-7
    [20] WANG W, LIU Y, YANG Y, et al. Adverse childhood and adulthood experiences and risk of new-onset cardiovascular disease with consideration of social support: a prospective cohort study[J]. BMC Med, 2023, 21(1): 297. doi: 10.1186/s12916-023-03015-1
    [21] HUGHES K, BELLIS M A, HARDCASTLE K A, et al. The effect of multiple adverse childhood experiences on health: a systematic review and Meta-analysis[J]. Lancet Public Health, 2017, 2(8): e356-e366. doi: 10.1016/S2468-2667(17)30118-4
    [22] ANDA R F, DONG M, BROWN D W, et al. The relationship of adverse childhood experiences to a history of premature death of family members[J]. BMC Public Health, 2009, 9: 106. doi: 10.1186/1471-2458-9-106
    [23] CRONHOLM P F, FORKE C M, WADE R, et al. Adverse childhood experiences: expanding the concept of adversity[J]. Am J Prev Med, 2015, 49(3): 354-361. doi: 10.1016/j.amepre.2015.02.001
    [24] BELLIS M A, HUGHES K, FORD K, et al. Life course health consequences and associated annual costs of adverse childhood experiences across Europe and North America: a systematic review and Meta-analysis[J]. Lancet Public Health, 2019, 4(10): e517-e528. doi: 10.1016/S2468-2667(19)30145-8
    [25] LIN L, WANG H H, LU C, et al. Adverse childhood experiences and subsequent chronic diseases among middle-aged or older adults in China and associations with demographic and socioeconomic characteristics[J]. JAMA Netw Open, 2021, 4(10): e2130143. doi: 10.1001/jamanetworkopen.2021.30143
    [26] FLORES-TORRES M H, COMERFORD E, SIGNORELLO L, et al. Impact of adverse childhood experiences on cardiovascular disease risk factors in adulthood among Mexican women[J]. Child Abuse Negl, 2020, 99: 104175. doi: 10.1016/j.chiabu.2019.104175
    [27] TRIVEDI G Y, PILLAI N, TRIVEDI R G. Adverse childhood experiences and mental health: the urgent need for public health intervention in India[J]. J Prev Med Hyg, 2021, 62(3): E728-E735.
    [28] TUNG E L, WROBLEWSKI K E, MAKELARSKI J A, et al. Childhood parental incarceration and adult-onset hypertension and cardiovascular risk[J]. JAMA Cardiol, 2023, 8(10): 927-935. doi: 10.1001/jamacardio.2023.2672
    [29] HUGHES K, FORD K, KADEL R, et al. Health and financial burden of adverse childhood experiences in England and Wales: a combined primary data study of five surveys[J]. BMJ Open, 2020, 10(6): e036374. doi: 10.1136/bmjopen-2019-036374
    [30] QIN F Z, YUAN M Q, ZHOU Z, et al. Progress in research of association of adverse childhood experiences with prevalence of common chronic diseases in adulthood[J]. Chin J Epidemiol, 2020, 41(11): 1933-1937.
    [31] LI J J, LIN S Q, WU J L, et al. A retrospective cohort study of the effects of the adverse childhood experience on chronic diseases of middle-aged and elderly[J]. Chin J Epidemiol, 2021, 42(10): 1804-1808.
    [32] GODOY L C, FRANKFURTER C, COOPER M, et al. Association of adverse childhood experiences with cardiovascular disease later in life: a review[J]. JAMA Cardiol, 2021, 6(2): 228-235. doi: 10.1001/jamacardio.2020.6050
    [33] DONG M, GILES W H, FELITTI V J, et al. Insights into causal pathways for ischemic heart disease: adverse childhood experiences study[J]. Circulation, 2004, 110(13): 1761-1766. doi: 10.1161/01.CIR.0000143074.54995.7F
    [34] BELLIS M A, HUGHES K, LECKENBY N, et al. Measuring mortality and the burden of adult disease associated with adverse childhood experiences in England: a national survey[J]. J Public Health (Oxf), 2015, 37(3): 445-454. doi: 10.1093/pubmed/fdu065
    [35] FOWLER C, HOMANDBERG L, STEELE C, et al. Adult correlates of adverse childhood experiences in Ukraine[J]. Child Abuse Negl, 2020, 107: 104617. doi: 10.1016/j.chiabu.2020.104617
    [36] O'LEARY E, MILLAR S R, PERRY I J, et al. Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population[J]. SSM Popul Health, 2023, 22: 101393. doi: 10.1016/j.ssmph.2023.101393
    [37] LIANG Y Y, AI S, WENG F, et al. Associations of childhood maltreatment and genetic risks with incident heart failure in later life[J]. J Am Heart Assoc, 2022, 11(20): e026536. doi: 10.1161/JAHA.122.026536
    [38] LIU Y, WANG C, LIU Y. Association between adverse childhood experiences and later-life cardiovascular diseases among middle-aged and older Chinese adults: the mediation effect of depressive symptoms[J]. J Affect Disord, 2022, 319: 277-285. doi: 10.1016/j.jad.2022.09.080
    [39] LLABRE M M, SCHNEIDERMAN N, GALLO L C, et al. Childhood trauma and adult risk factors and disease in Hispanics/Latinos in the US: results from the Hispanic community health study/study of Latinos (HCHS/SOL) sociocultural ancillary study[J]. Psychosom Med, 2017, 79(2): 172-180. doi: 10.1097/PSY.0000000000000394
    [40] DESCHêNES S S, KIVIMAKI M, SCHMITZ N. Adverse childhood experiences and the risk of coronary heart disease in adulthood: examining potential psychological, biological, and behavioral mediators in the Whitehall Ⅱ cohort study[J]. J Am Heart Assoc, 2021, 10(10): e019013. doi: 10.1161/JAHA.120.019013
    [41] LEE T K, WICKRAMA K A S, O'NEAL C W. Early socioeconomic adversity and cardiometabolic risk in young adults: mediating roles of risky health lifestyle and depressive symptoms[J]. J Behav Med, 2019, 42(1): 150-161. doi: 10.1007/s10865-018-9952-5
    [42] RICH-EDWARDS J W, MASON S, REXRODE K, et al. Physical and sexual abuse in childhood as predictors of early-onset cardiovascular events in women[J]. Circulation, 2012, 126(8): 920-927. doi: 10.1161/CIRCULATIONAHA.111.076877
    [43] CROUCH E, RADCLIFF E, STROMPOLIS M, et al. Examining the association between adverse childhood experiences and smoking-exacerbated illnesses[J]. Public Health, 2018, 157: 62-68. doi: 10.1016/j.puhe.2018.01.021
    [44] CHARTIER M J, WALKER J R, NAIMARK B. Health risk behaviors and mental health problems as mediators of the relationship between childhood abuse and adult health[J]. Am J Public Health, 2009, 99(5): 847-854. doi: 10.2105/AJPH.2007.122408
    [45] DAS-MUNSHI J, LEAVEY G, STANSFELD S A, et al. Does social disadvantage over the life-course account for alcohol and tobacco use in Irish people? Birth cohort study[J]. Eur J Public Health, 2014, 24(4): 594-599. doi: 10.1093/eurpub/ckt122
    [46] DONG M, ANDA R F, FELITTI V J, et al. Childhood residential mobility and multiple health risks during adolescence and adulthood: the hidden role of adverse childhood experiences[J]. Arch Pediatr Adolesc Med, 2005, 159(12): 1104-1110. doi: 10.1001/archpedi.159.12.1104
    [47] DUBE S R, COOK M L, EDWARDS V J. Health-related outcomes of adverse childhood experiences in Texas, 2002[J]. Prev Chronic Dis, 2010, 7(3): A52.
    [48] FULLER-THOMSON E, FILIPPELLI J, LUE-CRISOSTOMO C A. Gender-specific association between childhood adversities and smoking in adulthood: findings from a population-based study[J]. Public Health, 2013, 127(5): 449-460. doi: 10.1016/j.puhe.2013.01.006
    [49] MORTON P M, MUSTILLO S A, FERRARO K F. Does childhood misfortune raise the risk of acute myocardial infarction in adulthood?[J]. Soc Sci Med, 2014, 104: 133-141. doi: 10.1016/j.socscimed.2013.11.026
    [50] LOUCKS E B, ALMEIDA N D, TAYLOR S E, et al. Childhood family psychosocial environment and coronary heart disease risk[J]. Psychosom Med, 2011, 73(7): 563-571. doi: 10.1097/PSY.0b013e318228c820
    [51] HAZZARD V M, YOON C, EMERY R L, et al. Adverse childhood experiences in relation to mood-, weight-, and eating-related outcomes in emerging adulthood: does self-compassion play a buffering role?[J]. Child Abuse Negl, 2021, 122: 105307. doi: 10.1016/j.chiabu.2021.105307
    [52] SCHULER B R, VAZQUEZ C, KOBULSKY J M, et al. The early effects of cumulative and individual adverse childhood experiences on child diet: examining the role of socioeconomic status[J]. Prev Med, 2021, 145: 106447. doi: 10.1016/j.ypmed.2021.106447
    [53] JACKSON D B, VAUGHN M G. Parental incarceration and child sleep and eating behaviors[J]. J Pediatr, 2017, 185: 211-217. doi: 10.1016/j.jpeds.2017.03.026
    [54] FANG Y, XIA J, LIAN Y, et al. The burden of cardiovascular disease attributable to dietary risk factors in the provinces of China, 2002-2018: a nationwide population-based study[J]. Lancet Reg Health West Pac, 2023, 37: 100784.
    [55] SHIVAPPA N, GODOS J, HéBERT J R, et al. Dietary Inflammatory Index and cardiovascular risk and mortality: a Meta-analysis[J]. Nutrients, 2018, 10(2): 200. doi: 10.3390/nu10020200
    [56] KAJEEPETA S, GELAYE B, JACKSON C L, et al. Adverse childhood experiences are associated with adult sleep disorders: a systematic review[J]. Sleep Med, 2015, 16(3): 320-330. doi: 10.1016/j.sleep.2014.12.013
    [57] BAIDEN P, FALLON B, DEN DUNNEN W, et al. The enduring effects of early-childhood adversities and troubled sleep among Canadian adults: a population-based study[J]. Sleep Med, 2015, 16(6): 760-767. doi: 10.1016/j.sleep.2015.02.527
    [58] GANGWISCH J E. A review of evidence for the link between sleep duration and hypertension[J]. Am J Hypertens, 2014, 27(10): 1235-1242. doi: 10.1093/ajh/hpu071
    [59] JAVAHERI S, STORFER-ISSER A, ROSEN C L, et al. Sleep quality and elevated blood pressure in adolescents[J]. Circulation, 2008, 118(10): 1034-1040. doi: 10.1161/CIRCULATIONAHA.108.766410
    [60] BADRAN M, YASSIN B A, FOX N, et al. Epidemiology of sleep disturbances and cardiovascular consequences[J]. Can J Cardiol, 2015, 31(7): 873-879. doi: 10.1016/j.cjca.2015.03.011
    [61] TOTTENHAM N, HARE T A, MILLNER A, et al. Elevated amygdala response to faces following early deprivation[J]. Dev Sci, 2011, 14(2): 190-204. doi: 10.1111/j.1467-7687.2010.00971.x
    [62] POWELL N D, SLOAN E K, BAILEY M T, et al. Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis[J]. Proc Natl Acad Sci USA, 2013, 110(41): 16574-16579. doi: 10.1073/pnas.1310655110
    [63] HOSTINAR C E, LACHMAN M E, MROCZEK D K, et al. Additive contributions of childhood adversity and recent stressors to inflammation at midlife: findings from the MIDUS study[J]. Dev Psychol, 2015, 51(11): 1630-1644. doi: 10.1037/dev0000049
    [64] PFEFFER C R, ALTEMUS M, HEO M, et al. Salivary cortisol and psychopathology in children bereaved by the September 11, 2001 Terror Attacks[J]. Biol Psychiatry, 2007, 61(8): 957-965. doi: 10.1016/j.biopsych.2006.07.037
    [65] MILLER G E, CHEN E, FOK A K, et al. Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling[J]. Proc Natl Acad Sci USA, 2009, 106(34): 14716-14721. doi: 10.1073/pnas.0902971106
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出版历程
  • 收稿日期:  2023-11-29
  • 修回日期:  2023-12-13
  • 刊出日期:  2025-01-25

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