父母童年期创伤对青少年抑郁障碍代际影响的研究进展

陈佳佳; 李静雅; 杨楹

doi:10.16835/j.cnki.1000-9817.2024378

父母童年期创伤对青少年抑郁障碍代际影响的研究进展

doi: 10.16835/j.cnki.1000-9817.2024378

1.
滨州医学院特殊教育与康复学院，山东烟台 264003
2.
山东省精神卫生中心儿童青少年心理行为医学中心

基金项目:

山东省医药卫生科技项目 202303090513

详细信息

作者简介:
陈佳佳(1997-)，女，吉林延边人，在读硕士，主要研究方向为临床心理

通讯作者:
杨楹，E-mail：doctoryy2022@163.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: G78 B844.2 R179
计量
- 文章访问数: 197
- HTML全文浏览量: 62
- PDF下载量: 27
- 被引次数: 0
出版历程
- 收稿日期: 2024-07-31
- 修回日期: 2024-11-19
- 网络出版日期: 2025-01-07
- 刊出日期: 2024-12-25

Research progress of intergenerational effects of parental childhood trauma on adolescent depressive disorders

1.
School of Special Education and Rehabilitation, Binzhou Medical University, Yantai (264003), Shangdong Province, China

摘要

摘要: 为了解父母童年期创伤对青少年抑郁障碍的发生发展产生的代际影响及其机制，研究基于生物—心理—社会的整合医学模式，从多层次全面阐述父母童年期创伤与青少年抑郁障碍之间可能的作用机制。未来研究可进一步完善其代际影响机制，创建整合模型；并在此基础上提出预防及干预措施，提前阻断童年期创伤的恶性代际影响。
- 法定监护人 /
- 生活变动事件 /
- 抑郁 /
- 精神卫生 /
- 青少年
Abstract: In order to understand the intergenerational impact of parental childhood trauma on development of adolescent depression disorder and its mechanism, the study comprehensively elaborates possible mechanisms underlying association between parental childhood trauma and adolescent depressive disorders from multiple levels based on the biopsychosocial integrative medicine model. Future research is needed to further clarify possible mechanisms in an integrated model. Preventive and intervention measures can be proposed and early block the malignant of intergenerational influence of childhood trauma.
- Legal guardians /
- Life change events /
- Depression /
- Mental health /
- Adoescent
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

HTML全文

参考文献(52)

[1]	RIBEIRO J D, HUANG X, FOX K R, et al. Depression and hopelessness as risk factors for suicide ideation, attempts and death: Meta-analysis of longitudinal studies[J]. Br J Psychiatry, 2018, 212(5): 279-286. doi: 10.1192/bjp.2018.27
[2]	LI F, CUI Y, LI Y, et al. Prevalence of mental disorders in school children and adolescents in China: diagnostic data from detailed clinical assessments of 17 524 individuals[J]. J Child Psychol Psychiatry, 2022, 63(1): 34-46. doi: 10.1111/jcpp.13445
[3]	ARNOLD R, AHMED F, CLARKE A, et al. The relationship betw-een parental adverse childhood experiences and the health, well-being and development outcomes of their children: a systematic review[J]. Public Health, 2023, 219: 146-153. doi: 10.1016/j.puhe.2023.03.025
[4]	FELITTI V J, ANDA R F, NORDENBERG D, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The adverse childhood experiences (ACE) study[J]. Am J Prev Med, 1998, 14(4): 245-258. doi: 10.1016/S0749-3797(98)00017-8
[5]	GUSTAFSSON H, DOYLE C, GILCHRIST M, et al. Maternal abuse history and reduced fetal heart rate variability: abuse-related sleep disturbance is a mediator[J]. Dev Psychopathol, 2017, 29(3): 1023-1034. doi: 10.1017/S0954579416000997
[6]	SIERAU S, WARMINGHAM J, WHITE L O, et al. Childhood emotional and conduct problems in childhood and adolescence differentially associated with intergenerational maltreatment continuity and parental internalizing symptoms[J]. J Abnorm Child Psychol, 2020, 48(1): 29-42. http://pubmed.ncbi.nlm.nih.gov/31313061/
[7]	BUSH N R, NOROÑA-ZHOU A, COCCIA M, et al. Intergenerational transmission of stress: multi-domain stressors from maternal childhood and pregnancy predict children's mental health in a racially and socioeconomically diverse, multi-site cohort[J]. Soc Psychiatry Psychiatr Epidemiol, 2023, 58(11): 1625-1636. doi: 10.1007/s00127-022-02401-z
[8]	DENNIS C H, CLOHESSY D S, STONE A L, et al. Adverse childhood experiences in mothers with chronic pain and intergenerational impact on children[J]. J Pain, 2019, 20(10): 1209-1217. doi: 10.1016/j.jpain.2019.04.004
[9]	BABCOCK FENERCI R L, ALLEN B. From mother to child: maternal betrayal trauma and risk for maltreatment and psychopathology in the next generation[J]. Child Abuse Negl, 2018, 82: 1-11. doi: 10.1016/j.chiabu.2018.05.014
[10]	HAYNES E, CROUCH E, PROBST J, et al. Exploring the association between a parent's exposure to adverse childhood experiences (ACEs) and outcomes of depression and anxiety among their children[J]. Child Youth Serv Rev, 2020, 113: 105013. doi: 10.1016/j.childyouth.2020.105013
[11]	MOOG N K, CUMMINGS P D, JACKSON K L, et al. Intergenerational transmission of the effects of maternal exposure to childhood maltreatment in the USA: a retrospective cohort study[J]. Lancet Public health, 2023, 8(3): e226-e237. doi: 10.1016/S2468-2667(23)00025-7
[12]	NORMAN R E, BYAMBAA M, DE R, et al. The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and Meta-analysis[J]. PLoS Med, 2012, 9(11): e1001349. doi: 10.1371/journal.pmed.1001349
[13]	JIN Y, XU S, HU Z, et al. Co-occurrence of PTSD and affective symptoms in a large sample with childhood trauma subtypes: a network analysis[J]. Front Public Health, 2023, 11: 1093687. doi: 10.3389/fpubh.2023.1093687
[14]	LETOURNEAU N, DEWEY D, KAPLAN B J, et al. Intergenerational transmission of adverse childhood experiences via maternal depression and anxiety and moderation by child sex[J]. J Dev Orig Health Dis, 2019, 10(1): 88-99. doi: 10.1017/S2040174418000648
[15]	BARNETT M A, SCARAMELLA L V. Mothers' parenting and child sex differences in behavior problems among African American preschoolers[J]. J Fam Psychol, 2013, 27(5): 773-783. doi: 10.1037/a0033792
[16]	OSHIO T, UMEDA M. Gender-specific linkages of parents' childhood physical abuse and neglect with children's problem behaviour: evidence from Japan[J]. BMC public health, 2016, 16: 403. doi: 10.1186/s12889-016-3072-3
[17]	GRAIGNIC-PHILIPPE R, DAYAN J, CHOKRON S, et al. Effects of prenatal stress on fetal and child development: a critical literature review[J]. Neurosci Biobehav Rev, 2014, 43: 137-162. doi: 10.1016/j.neubiorev.2014.03.022
[18]	CHAN J C, NUGENT B M, BALE T L. Parental advisory: maternal and paternal stress can impact offspring neurodevelopment[J]. Biol Psychiatry, 2018, 83(10): 886-894. doi: 10.1016/j.biopsych.2017.10.005
[19]	KANG C, SHI J, GONG Y, et al. Interaction between FKBP5 polymorphisms and childhood trauma on depressive symptoms in Chinese adolescents: the moderating role of resilience[J]. J Affect Disord, 2020, 266: 143-150. doi: 10.1016/j.jad.2020.01.051
[20]	BUSS C, ENTRINGER S, MOOG N K, et al. Intergenerational transmission of maternal childhood maltreatment exposure: implications for fetal brain development[J]. J Am Acad Child Adolesc Psychiatry, 2017, 56(5): 373-382. doi: 10.1016/j.jaac.2017.03.001
[21]	LI M, LIU S, D'ARCY C, et al. Interactions of childhood maltreatment and genetic variations in adult depression: a systematic review[J]. J Affect Disord, 2020, 276: 119-136. doi: 10.1016/j.jad.2020.06.055
[22]	ROBAKIS T K, ROTH M C, KING L S, et al. Maternal attachment insecurity, maltreatment history, and depressive symptoms are associated with broad DNA methylation signatures in infants[J]. Mol Psychiatry, 2022, 27(8): 3306-3315. doi: 10.1038/s41380-022-01592-w
[23]	MERRILL S M, MOORE S R, GLADISH N, et al. Paternal adverse childhood experiences: associations with infant DNA methylation[J]. Dev Psychobiol, 2021, 63(6): e22174. doi: 10.1002/dev.22174
[24]	THOMAS-ARGYRIOU J C, LETOURNEAU N, DEWEY D, et al. The role of HPA-axis function during pregnancy in the intergenerational transmission of maternal adverse childhood experiences to child behavior problems[J]. Dev Psychopathol, 2021, 33(1): 284-300. doi: 10.1017/S0954579419001767
[25]	BROEKS C W, MOLENAAR N, BROUWER M, et al. Intergenerational impact of childhood trauma on hair cortisol concentrations in mothers and their young infants[J]. Compr Psychoneuroendocrinol, 2023, 14: 100167. doi: 10.1016/j.cpnec.2023.100167
[26]	DANIELSON C K, HANKIN B L, BADANES L S. Youth offspring of mothers with posttraumatic stress disorder have altered stress reactivity in response to a laboratory stressor[J]. Psychoneuroendocrinology, 2015, 53: 170-178. doi: 10.1016/j.psyneuen.2015.01.001
[27]	RAMDAS D L, SBRILLI M D, LAURENT H K. Impact of maternal trauma-related psychopathology and life stress on HPA axis stress response[J]. Arch Womens Ment Health, 2022, 25(1): 121-128. doi: 10.1007/s00737-021-01169-6
[28]	MADIGAN S, WADE M, PLAMONDON A, et al. Maternal adverse childhood experience and infant health: biomedical and psychosocial risks as intermediary mechanisms[J]. J Pediatr, 2017, 187: 282-289. doi: 10.1016/j.jpeds.2017.04.052
[29]	KUNIMATSU A, YASAKA K, AKAI H, et al. MRI findings in posttraumatic stress disorder[J]. JMRI, 2020, 52(2): 380-396. doi: 10.1002/jmri.26929
[30]	MOOG N K, ENTRINGER S, RASMUSSEN J M, et al. Intergenerational effect of maternal exposure to childhood maltreatment on newborn brain anatomy[J]. Biol Psychiatry, 2018, 83(2): 120-127. doi: 10.1016/j.biopsych.2017.07.009
[31]	KHOURY J E, AHTAM B, SISITSKY M, et al. Maternal childhood maltreatment is associated with lower infant gray matter volume and amygdala volume during the first two years of life[J]. Biol Psychiatry Glob Open Sci, 2022, 2(4): 440-449. doi: 10.1016/j.bpsgos.2021.09.005
[32]	冯文泰, 阳洁, 周敏思, 等. 母亲童年创伤对青少年抑郁患者创伤、焦虑及杏仁核脑网络影响[J]. 国际精神病学杂志, 2024, 51(3): 783-787, 791. FENG W T, YANG J, ZHOU M S, et al. The impact of maternal childhood trauma affecting trauma, anxiety and amygdala brain network in adolescent depressed patient[J]. J Int Psychiatry, 2024, 51(3): 783-787, 791. (in Chinese)
[33]	SCHMAAL L, VELTMAN D J, VAN ERP T G, et al. Subcortical brain alterations in major depressive disorder: findings from the ENIGMA major depressive disorder working group[J]. Mol Psychiatry, 2016, 21(6): 806-812. doi: 10.1038/mp.2015.69
[34]	RECK C, NONNENMACHER N, ZIETLOW A L. Intergenerational transmission of internalizing behavior: the role of maternal psychopathology, child responsiveness and maternal attachment style insecurity[J]. Psychopathology, 2016, 49(4): 277-284. doi: 10.1159/000446846
[35]	ROTH M C, HUMPHREYS K L, KING L S, et al. Attachment security in pregnancy mediates the association between maternal childhood maltreatment and emotional and behavioral problems in offspring[J]. Child Psychiatry Hum Dev, 2021, 52(5): 966-977. doi: 10.1007/s10578-020-01073-7
[36]	COOKE J E, RACINE N, PLAMONDON A, et al. Maternal adverse childhood experiences, attachment style, and mental health: pathways of transmission to child behavior problems[J]. Child Abuse Negl, 2019, 93: 27-37. doi: 10.1016/j.chiabu.2019.04.011
[37]	SROUFE L A. Attachment and development: a prospective, longitudinal study from birth to adulthood[J]. Attach Hum Dev, 2005, 7(4): 349-367. doi: 10.1080/14616730500365928
[38]	HUMPHREYS K L, LEMOULT J, WEAR J G, et al. Child maltreatment and depression: a Meta-analysis of studies using the Childhood Trauma Questionnaire[J]. Child Abuse Negl, 2020, 102: 104361. doi: 10.1016/j.chiabu.2020.104361
[39]	BERNARD K, NISSIM G, VACCARO S, et al. Association between maternal depression and maternal sensitivity from birth to 12 months: a Meta-analysis[J]. Attach Hum Dev, 2018, 20(6): 578-599. doi: 10.1080/14616734.2018.1430839
[40]	CHOI K W, HOUTS R, ARSENEAULT L, et al. Maternal depression in the intergenerational transmission of childhood maltreatment and its sequelae: testing postpartum effects in a longitudinal birth cohort[J]. Dev Psychopathol, 2019, 31(1): 143-156. doi: 10.1017/S0954579418000032
[41]	BANDURA A. Social learning theory[D]. Englewood Cliffs, NJ: Pre-ntice Hall, 2017.
[42]	ROWELL T, NEAL-BARNETT A. A systematic review of the effect of parental adverse childhood experiences on parenting and child psychopathology[J]. J Child Adolesc Trauma, 2022, 15(1): 167-180. doi: 10.1007/s40653-021-00400-x
[43]	BARTLETT J D, KOTAKE C, FAUTH R, et al. Intergenerational transmission of child abuse and neglect: do maltreatment type, perpetrator, and substantiation status matter?[J]. Child Abuse Negl, 2017, 63: 84-94. doi: 10.1016/j.chiabu.2016.11.021
[44]	BRAVO P, KIM Y, XERXA Y, et al. Maternal history of maltreatment and offspring's emotional and behavioral problems in adolescence: do family factors contribute to the intergenerational risk transmission?[J]. Child Abuse Negl, 2023, 141: 106228. doi: 10.1016/j.chiabu.2023.106228
[45]	CARLSON B E, MCNUTT L A, CHOI D Y. Childhood and adult abuse among women in primary health care: effects on mental health[J]. J Interpers Violence, 2003, 18(8): 924-941. doi: 10.1177/0886260503253882
[46]	FITZGERALD M, MORGAN A A. Marital quality and depression as mediators linking childhood maltreatment to adult physical health[J]. Child Abuse Negl, 2023, 141: 106189. doi: 10.1016/j.chiabu.2023.106189
[47]	REYNOLDS M W, WALLACE J, HILL T F, et al. The relationship between gender, depression, and self-esteem in children who have witnessed domestic violence[J]. Child Abuse Negl, 2001, 25(9): 1201-1206. doi: 10.1016/S0145-2134(01)00269-1
[48]	CUMMINGS E M, MILLER-GRAFF L E. Emotional security theory: an emerging theoretical model for youths' psychological and physiological responses across multiple developmental contexts[J]. Curr Dir Psychol Sci, 2015, 24(3): 208-213. doi: 10.1177/0963721414561510
[49]	MCFARLANE J, FREDLAND N M, SYMES L, et al. The intergenerational impact of intimate partner violence against mothers on child functioning over four years[J]. J Fam Violence, 2017, 32: 645-655. doi: 10.1007/s10896-017-9913-8
[50]	ST-LAURENT D, DUBOIS-COMTOIS K, MILOT T, et al. Intergenerational continuity/discontinuity of child maltreatment among low-income mother-child dyads: the roles of childhood maltreatment characteristics, maternal psychological functioning, and family ecology[J]. Dev Psychopathol, 2019, 31(1): 189-202. doi: 10.1017/S095457941800161X
[51]	DE CARLI P, TAGINI A, SARRACINO D, et al. Like grandparents, like parents: empirical evidence and psychoanalytic thinking on the transmission of parenting styles[J]. Bull Menninger Clin, 2018, 82(1): 46-70. doi: 10.1521/bumc_2017_81_11
[52]	MAL-SARKAR T, KEYES K, KOEN N, et al. The relationship between childhood trauma, socioeconomic status, and maternal depression among pregnant women in a South African birth cohort study[J]. SSM Popul Health, 2021, 14: 100770. http://pubmed.ncbi.nlm.nih.gov/33855159/