男男同性性行为学生HIV感染者抗病毒治疗现况及相关因素

岳腾; 程朝御; 鲜伊丹; 刘萱; 魏思月; 刘媛媛; 刘凤利; 杨杰; 于茂河; 李长平; 崔壮

doi:10.16835/j.cnki.1000-9817.2024373

男男同性性行为学生HIV感染者抗病毒治疗现况及相关因素

doi: 10.16835/j.cnki.1000-9817.2024373

1.
天津医科大学公共卫生学院流行病与卫生统计学系，天津 300070
2.
天津深蓝公共卫生咨询服务中心
3.
天津市疾病预防控制中心性病艾滋病预防控制所

基金项目:

国家自然科学基金面上项目 72374153

教育部人文社会科学研究规划基金项目 20YJAZH021

天津市卫生健康科技项目 ZC20022

详细信息

通讯作者:
崔壮，E-mail：cuizhuang@tmu.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R167 R512.91
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- 被引次数: 0
出版历程
- 收稿日期: 2024-09-30
- 修回日期: 2024-11-01
- 网络出版日期: 2025-01-07
- 刊出日期: 2024-12-25

Current status and related factors of antiviral treatment among HIV-infected men who have sex with men students

1.
Department of Epidemiology and Health Statistics, School of Public Health, Tianjin Medical University, Tianjin(300070), China

摘要

摘要: 目的探讨男男同性性行为(MSM)学生艾滋病病毒(HIV)感染者抗病毒治疗现状及相关因素，为HIV防治提供参考依据。方法 2021年11月招募中国31个省级行政区的137名MSM学生HIV感染者开展线上调查，描述人口学特征、抗逆转录病毒治疗(ART)服药情况及治疗前后的CD4和HIV病毒载量水平等。采用Logistic回归分析MSM学生抗病毒治疗效果的相关因素。结果在纳入的研究对象中，14.6%为HIV晚发现，97.1%正在进行ART；排除启动治疗不足6个月的感染者后，病毒完全抑制率达到76.9%。Logistic回归分析结果显示，服药时间>24个月的学生HIV感染者(OR=5.28，95%CI=1.38~20.22)更可能ART抑制成功，报告有身体感受方面副作用(OR=0.08，95%CI=0.01~0.71)和认知方面副作用(OR=0.28，95%CI=0.09~0.90)的学生HIV感染者更可能造成ART抑制失败(P值均 < 0.05)。结论 MSM学生群体中ART的疗效仍有上升空间，应采取措施提高治疗依从性，在制定治疗方案时需充分考虑HIV感染者的个体差异和药物副作用。
- 同性恋，男性 /
- HIV感染 /
- 回归分析 /
- 学生
Abstract: Objective To investigate the current situation and related factors of antiretroviral therapy (ART) among HIV-infected male students engaging in men who have sex with men (MSM), so as to provide the reference data for HIV prevention and treatment. Methods In November 2021, 137 MSM students from 31 provincial administrative regions in China were recruited. An online survey was conducted to collect data on demographic characteristics, ART status, CD4 count, and HIV viral load before treatment. Logistic regression was used to analyze the factors related the effectiveness of ART in MSM. Results Among the included research subjects, 14.6% had late detection of HIV, 97.1% of participants were currently undergoing ART. Among those whose ART duration was less than 6 months, while 76.9% were undergoing ART. Logistic regression indicated that HIV-infected students who received ART for more than 24 months (OR=5.28, 95%CI=1.38-20.22) had a higher rate of successful HIV suppression. HIV-infected students who reported physical sensory side effects (OR=0.08, 95%CI=0.01-0.71) and cognitive side effects (OR=0.28, 95%CI=0.09-0.90) were more likely to experience failure of ARI inhibition (P < 0.05). Conclusions There is still room for improvement in the efficacy of ART among MSM students. Strategies to improve treatment adherence must consider individual variances among HIV-infected patients and the side effects of medications when designing treatment plans.
- Homosexuality, male /
- HIV infections /
- Regression analysis /
- Students
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

HTML全文

表 1 不同组别MSM学生中HIV感染者ART及时性和治疗效果分布比较

Table 1. Comparison of timeliness and treatment outcomes of ART in HIV-infected MSM students across different groups

组别	选项	人数	统计值	及时启动 ART		最近一次检测 CD4水平/(个·μg^-1)		最近一次检测病毒载量水平/(拷贝·mL^-1)
组别	选项	人数	统计值	否	是	>200	≤200	>200	≤200
学历	高中及中专	7		1(14.3)	6(85.7)	6(85.7)	1(14.3)	3(42.9)	4(57.1)
	大专及以上	84		2(2.4)	82(97.6)	81(96.4)	3(3.6)	18(21.4)	66(78.6)
			P值	0.22^*		0.28^*		0.35^*
人均月收入/元	< 3 000	15		1(6.7)	14(93.3)	15(100.0)	0	2(13.3)	13(86.7)
人均月收入/元	≥3 000	76		2(2.6)	74(97.4)	72(94.7)	4(5.3)	19(25.0)	57(75.0)
			P值	0.42^*		0.83^*		0.51^*
年龄/岁	≤22	59		1(1.7)	58(98.3)	56(94.9)	3(5.1)	16(27.1)	43(72.9)
	>22	32		2(6.3)	30(93.8)	31(96.9)	1(3.1)	5(15.6)	27(84.4)
			χ²值	-		-		1.54
			P值	0.28^*		1.00^*		0.21
注：()内数字为构成比/%；*为Fisher检验。

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