生命早期因素对肠道菌群与儿童肥胖的影响及干预研究进展

夏志伟; 宫照龙; 孙静; 郭欣; 李岩; 霍军生

doi:10.16835/j.cnki.1000-9817.2024314

生命早期因素对肠道菌群与儿童肥胖的影响及干预研究进展

doi: 10.16835/j.cnki.1000-9817.2024314

夏志伟^{1, 2},
宫照龙¹,
孙静¹,
郭欣²,
李岩¹,
霍军生^1, ,

1.
中国疾病预防控制中心营养与健康所中心实验室/国家卫生健康委员会公共营养与健康重点实验室，北京 100050
2.
北京市疾病预防控制中心学校卫生所

基金项目:

国家重点研发计划项目 2020YFC2006301

国家财政资助项目 102393220020070000016

详细信息

作者简介:
夏志伟(1989-)，男，安徽铜陵人，在读博士，主管医师，主要研究方向为儿童青少年营养健康

通讯作者:
霍军生，E-mail: huojs@ninh.chinacdc.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R723.14 R714.14⁺⁶
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- 文章访问数: 105
- HTML全文浏览量: 48
- PDF下载量: 21
- 被引次数: 0
出版历程
- 收稿日期: 2024-01-18
- 修回日期: 2024-06-26
- 网络出版日期: 2024-12-10
- 刊出日期: 2024-11-15

Research progress on the impact and intervention of early life factors on gut microbiota and childhood obesity

XIA Zhiwei^{1, 2},
GONG Zhaolong¹,
SUN Jing¹,
GUO Xin²,
LI Yan¹,
HUO Junsheng^{1
, ,}

1.
Center Laboratory of National Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention/NHC Key Laboratory of Public Nutrition and Health, Beijing (100050), China

摘要

摘要: 儿童肥胖是全球重大的公共卫生挑战之一，对儿童青少年的身心健康具有深远影响。文章综述生命早期肠道菌群的建立及早期营养状况与喂养方式、母婴菌群交换、分娩方式和抗菌药物使用等因素对肠道菌群及儿童肥胖的影响，重点探讨利用肠道菌群结构特征(基因丰富度和均匀度、细菌相对丰度比例及关键指示菌)作为肥胖儿童干预的潜在靶点和预测因子的可能性，并总结益生菌等生物制剂及肠道粪便转移在儿童肥胖干预中的应用及肠道菌群与儿童肥胖发生机制的最新进展，从而为精准防控儿童肥胖提供参考。
- 胃肠道 /
- 细菌 /
- 肥胖症 /
- 生命周期各时期 /
- 干预 /
- 儿童
Abstract: Childhood obesity is one of the major global public health challenges and has a profound impact on the physical and mental health of children and adolescents. The article summarizes the establishment of gut microbiota in early life and the influences of early nutritional status and feeding patterns, maternal and infant microbiota transmission, delivery methods and the use of antibiotics on gut microbiota and childhood obesity. The paper focuses on the possibility of using the structural characteristics of gut microbiota (gene richness and evenness, relative abundance ratio and key indicator bacteria) as potential interventional targets and predictors of intervention effects in childhood obesity, and introduces the application of probiotics and other biological agents, as well as fecal microbiota transfer for the childhood obesity intervention, and briefly describes the latest progress in the mechanism of gut microbiota and childhood obesity, so as to provide the reference for the precise prevention and control of childhood obesity.
- Gastrointestinal tract /
- Bacteria /
- Obesity /
- Life cycle stages /
- Intervention /
- Child
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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