生命早期不良暴露与子代视力异常的研究进展

刘诗音; 游雪; 林晓妍; 麦凯童; 刘星彤; 曹梦婷; 杜江波

doi:10.16835/j.cnki.1000-9817.2024242

生命早期不良暴露与子代视力异常的研究进展

doi: 10.16835/j.cnki.1000-9817.2024242

刘诗音¹,
游雪²,
林晓妍¹,
麦凯童¹,
刘星彤²,
曹梦婷²,
杜江波^{2, 3, ,}

1.
南京医科大学第一临床医学院，江苏 210029
2.
南京医科大学公共卫生学院流行病学系/全球健康研究中心
3.
南京医科大学生殖医学与子代健康全国重点实验室

基金项目:

国家重点研发计划项目 2021YFC2700705

大学生创新创业训练计划项目 202310312014Z

详细信息

作者简介:
刘诗音(2002-)，女，陕西省人，在读本科

通讯作者:
杜江波，E-mail：dujiangbo@njmu.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R778.1 R771 R715.3
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- 文章访问数: 181
- HTML全文浏览量: 70
- PDF下载量: 29
- 被引次数: 0
出版历程
- 收稿日期: 2024-03-22
- 修回日期: 2024-05-16
- 网络出版日期: 2024-08-31
- 刊出日期: 2024-08-25

Research progress of adverse exposure in early life and abnormal visual acuity in offspring

1.
The First School of Clinical Medicine, Nanjing Medical University, Nanjing (210029), Jiangsu Province, China

摘要

摘要: 近年来，儿童眼部疾病的防治已成为全球范围内广泛关注的公共卫生问题之一。由于遗传因素与环境因素均可影响子代视觉系统的形成，导致屈光不正、斜视、眼球震颤等视力异常情况出现。文章从孕期烟草暴露、微量元素暴露、妊娠期糖尿病、妊娠期高血压及孕期药物滥用等方面对生命早期暴露与子代视力结局的研究进行总结，旨在阐明生命早期不良暴露与子代视力结局的影响因素及其机制，为制定更有效的儿童青少年眼部疾病防治策略提供科学依据。
- 烟草 /
- 微量营养系 /
- 糖尿病，妊娠 /
- 高血压，妊娠性 /
- 视力，低 /
- 儿童
Abstract: In recent years, the prevention and treatment of eye diseases in children has become one of the worldwide recognized public health issues. Both genetic and environmental factors can influence the development of offspring visual systems, leading to abnormal vision acuity such as refractive errors, strabismus, and nystagmus. With the aim of elucidating the influencing factors and mechanisms of early life adverse exposures on offspring vision outcomes, the article summarizes the research on exposure in early life and visual acuity in offspring from different perspectives, including tobacco exposure during pregnancy, exposure to microelements, gestational diabetes, gestational hypertension, and drug abuse during pregnancy, so as to provide scientific evidence for the development of more effective strategies to prevent and control eye diseases in children and adolescents.
- Tobacco /
- Mincronutrients /
- Diabetes, gestational /
- Hypertension, pregnancy-induced /
- Vision, low /
- Child
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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参考文献(63)

[1]	邹丛光, 魏科, 李厚源, 等. 中小学生近视矫正状况及对视力相关生存质量的影响[J]. 中国学校卫生, 2023, 44(8): 1252-1255, 1260. doi: 10.16835/j.cnki.1000-9817.2023.08.030 ZOU C G, WEI K, LI H Y, et al. Quality of vision-related survival among primary and secondary school students with different myopia correction status[J]. Chin J Sch Health, 2023, 44(8): 1252-1255, 1260. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2023.08.030
[2]	BURTON M J, RAMKE J, MARQUES A P, et al. The lancet global health commission on global eye health: vision beyond 2020[J]. Lancet Global Health, 2021, 9(4): e489-e551. doi: 10.1016/S2214-109X(20)30488-5
[3]	CHEN M J, GUAN Y S, HUANG R, et al. Associations between the maternal exposome and metabolome during pregnancy[J]. Environ Health Perspect, 2022, 130(3): 37003. doi: 10.1289/EHP9745
[4]	LAMBERT J E, PEELER C E. Visual and oculomotor outcomes in children with prenatal opioid exposure[J]. Curr Opin Ophthalmol, 2019, 30(6): 449-453. doi: 10.1097/ICU.0000000000000604
[5]	国家疾控局综合司关于印发《儿童青少年近视防控公共卫生综合干预技术指南》的通知[EB/OL]. (2023-08-30)[2023-10-02]. https://mp.weixin.qq.com/s/6xf6gb_vVLtDtQRJS_j5XQ. Department of General Affairs of the National Disease Control and Prevention issuing a circular on the Technical Guidelines for Comprehensive Public Health Intervention for Myopia Prevention and Control in Children and Adolescents[EB/OL]. (2023-08-30)[2023-10-02]. https://mp.weixin.qq.com/s/6xf6gb_vVLtDtQRJS_j5XQ. (in Chinese)
[6]	中华人民共和国国家卫生健康委发布《中国吸烟危害健康报告2020》[EB/OL]. (2021-05-30)[2023-08-25]. https://www.gov.cn/xinwen/2021-05/30/content_5613994.htm. National Health Commission of the PRC issuing the Report on the Health Hazards of Smoking in China in 2020[EB/OL]. (2021-05-30)[2023-08-25]. https://www.gov.cn/xinwen/2021-05/30/content_5613994.htm. (in Chinese)
[7]	WILLS L, ABLES J L, BRAUNSCHEIDEL K M, et al. Neurobiological mechanisms of nicotine reward and aversion[J]. Pharmacol Rev, 2022, 74(1): 271-310. doi: 10.1124/pharmrev.121.000299
[8]	KIM K, PICCIOTTO M R. Nicotine addiction: more than just dopamine[J]. Curr Opin Neurobiol, 2023, 83: 102797. doi: 10.1016/j.conb.2023.102797
[9]	STONE R A. Associations between childhood refraction and parental smoking[J]. Invest Ophthalmol Vis Sci, 2006, 47(10): 4277-4287. doi: 10.1167/iovs.05-1625
[10]	HARB E N, WILDSOET C F. Origins of refractive errors: environmental and genetic factors[J]. Annu Rev Vis Sci, 2019, 5(1): 47-72. doi: 10.1146/annurev-vision-091718-015027
[11]	BORCHERT M S, VARMA R, COTTER S A, et al. Risk factors for hyperopia and myopia in preschool children[J]. Ophthalmology, 2011, 118(10): 1966-1973. doi: 10.1016/j.ophtha.2011.06.030
[12]	JIANG X, TARCZY-HORNOCH K, STRAM D, et al. Prevalence, characteristics, and risk factors of moderate or high hyperopia among multiethnic children 6 to 72 months of age[J]. Ophthalmology, 2019, 126(7): 989-999. doi: 10.1016/j.ophtha.2019.02.021
[13]	MCKEAN-COWDIN R, VARMA R, COTTER S A, et al. Risk factors for astigmatism in preschool children[J]. Ophthalmology, 2011, 118(10): 1974-1981. doi: 10.1016/j.ophtha.2011.06.031
[14]	LI C G, YANG G Y, SCHMID K L, et al. Associations between environmental tobacco smoke exposure in early life and astigmatism among Chinese preschool children[J]. Int J Environ Res Public Health, 2019, 16(19): 3725. doi: 10.3390/ijerph16193725
[15]	KARIMI S, NOURI H, MAHMOUDINEJAD-AZAR S, et al. Smoking and environmental tobacco smoke exposure: implications in ocular disorders[J]. Cutan Ocul Toxicol, 2023, 42(1): 1-7. doi: 10.1080/15569527.2022.2144874
[16]	CHAN H S, TANG Y M, DO C W, et al. Design and assessment of amblyopia, strabismus, and myopia treatment and vision training using virtual reality[J]. Digit Health, 2023, 9: 20552076231176638. doi: 10.1177/20552076231176638
[17]	ZHANG X J, LAU Y H, WANG Y M, et al. Prevalence of strabismus and its risk factors among school aged children: the Hong Kong Children Eye Study[J]. Sci Rep, 2021, 11(1): 13820. doi: 10.1038/s41598-021-93131-w
[18]	YANG Y, WANG C, GAN Y, et al. Maternal smoking during pregnancy and the risk of strabismus in offspring: a Meta-analysis[J]. Acta Ophthalmol, 2019, 97(4): 353-363. doi: 10.1111/aos.13953
[19]	CHEW E. Risk factors for esotropia and exotropia[J]. Arch Ophthalmol, 1994, 112(10): 1349. doi: 10.1001/archopht.1994.01090220099030
[20]	LI L, QI Y, SHI W, et al. A Meta-analysis for association of maternal smoking with childhood refractive error and amblyopia[J]. J Ophthalmol, 2016, 2016: 8263832.
[21]	GRANET D B, KHAYALI S. Amblyopia and strabismus[J]. Pediatr Ann, 2011, 40(2): 89-94. doi: 10.3928/00904481-20110117-08
[22]	AFRIDI H I, KAZI T G, KAZI N, et al. Evaluation of status of cadmium, lead, and nickel levels in biological samples of normal and night blindness children of age groups 3-7 and 8-12 years[J]. Biol Trace Elem Res, 2011, 142(3): 350-361. doi: 10.1007/s12011-010-8796-9
[23]	STOJSAVLJEVIC A, PEROVIC M, NESŠIC A, et al. Levels of non-essential trace metals and their impact on placental health: a review[J]. Environ Sci Pollut Res, 2022, 29(29): 43662-43674. doi: 10.1007/s11356-022-20205-1
[24]	SILVER M K, LI X, LIU Y, et al. Low-level prenatal lead exposure and infant sensory function[J]. Environ Health, 2016, 15(1): 65. doi: 10.1186/s12940-016-0148-6
[25]	ALLEN K A. Is prenatal lead exposure a concern in infancy? What is the evidence?[J]. Adv Neonatal Care, 2015, 15(6): 416-420. doi: 10.1097/ANC.0000000000000224
[26]	ETHIER A A, MUCKLE G, BASTIEN C, et al. Effects of environmental contaminant exposure on visual brain development: a prospective electrophysiological study in school-aged children[J]. Neurotoxicology, 2012, 33(5): 1075-1085. doi: 10.1016/j.neuro.2012.05.010
[27]	ROTHENBERG S J, SCHNAAS L, SALGADO-VALLADARES M, et al. Increased ERG a- and b-wave amplitudes in 7- to 10-year-old children resulting from prenatal lead exposure[J]. Invest Ophthalmol Vis Sci, 2002, 43(6): 2036-2044.
[28]	TCHOUNWOU P B, AYENSU W K, NINASHVILI N, et al. Environmental exposure to mercury and its toxicopathologic implications for public health[J]. Environ Toxicol, 2003, 18(3): 149-175. doi: 10.1002/tox.10116
[29]	TONG M, YU J, LIU M, et al. Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring[J]. Environ Int, 2021, 150: 106425. doi: 10.1016/j.envint.2021.106425
[30]	MURATA K, WEIHE P, RENZONI A, et al. Delayed evoked potentials in children exposed to methylmercury from seafood[J]. Neurotoxicol Teratol, 1999, 21(4): 343-348. doi: 10.1016/S0892-0362(99)00011-2
[31]	WANG Z, DOU Y, GUO W, et al. Association between prenatal exposure to trace elements mixture and visual acuity in infants: a prospective birth cohort study[J]. Chemosphere, 2023, 333: 138905. doi: 10.1016/j.chemosphere.2023.138905
[32]	ZHAO H, WU W, ZHANG X, et al. Associations between molybdenum exposure and ultrasound measures of fetal growth parameters: a pilot study[J]. Chemosphere, 2021, 269: 128709. doi: 10.1016/j.chemosphere.2020.128709
[33]	VÁZQUEZ-SALAS R A, LÓPEZ-CARRILLO L, MENEZES-FILHO J A, et al. Prenatal molybdenum exposure and infant neurodevelopment in Mexican children[J]. Nutr Neurosci, 2014, 17(2): 72-80. doi: 10.1179/1476830513Y.0000000076
[34]	PIECZYNSKA J, PŁACZKOWSKA S, SOZANSKI R, et al. Effect of nickel on red blood cell parameters and on serum vitamin B₁₂, folate and homocysteine concentrations during pregnancy with and without anemia[J]. J Trace Elem Med Biol, 2021, 68: 126839. doi: 10.1016/j.jtemb.2021.126839
[35]	KATKO M, KISS I, KARPATI I, et al. Relationship between serum nickel and homocysteine concentration in hemodialysis patients[J]. Biol Trace Elem Res, 2008, 124(3): 195-205. doi: 10.1007/s12011-008-8139-2
[36]	甘虹, 陶芳标. 妊娠期糖尿病对儿童认知功能发育的影响[J]. 中国学校卫生, 2020, 41(8): 1267-1270. doi: 10.16835/j.cnki.1000-9817.2020.08.041 GAN H, TAO F B. The impact of gestational diabetes mellitus on the development of cognitive function in children[J]. Chin J Sch Health, 2020, 41(8): 1267-1270. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2020.08.041
[37]	DU J, LI J, LIU X, et al. Association of maternal diabetes during pregnancy with high refractive error in offspring: a nationwide population-based cohort study[J]. Diabetologia, 2021, 64(11): 2466-2477. doi: 10.1007/s00125-021-05526-z
[38]	XU Q, ZHANG F, LI J, et al. Association of maternal diabetes during pregnancy with visual acuity development in offspring: a prospective cohort study[J]. Acta Diabetol, 2022, 59(11): 1461-1468. doi: 10.1007/s00592-022-01933-9
[39]	刘冬杰, 宣勤, 董淑玥, 等. 早产儿视网膜出血的危险因素分析及临床探讨[J]. 中国卫生标准管理, 2022, 13(17): 10-13. https://www.cnki.com.cn/Article/CJFDTOTAL-WSBZ202217003.htm LIU D J, XUAN Q, DONG S Y, et al. Analysis and clinical study on the risk factors of retinal hemorrhage in premature infants[J]. Chin Health Stand Manage, 2022, 13(17): 10-13. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-WSBZ202217003.htm
[40]	GÖNCÜ T, CAKMAK A, AKAL A, et al. Comparison of refractive error and central corneal thickness in neonates of diabetic and healthy mothers[J]. Eur J Ophthalmol, 2015, 25(5): 396-399. doi: 10.5301/ejo.5000601
[41]	RICCI B, SCULLICA M G, RICCI F, et al. Iris vascular changes in newborns of diabetic mothers[J]. Ophthalmologica, 1998, 212(3): 175-177. doi: 10.1159/000027271
[42]	TARIQ Y M, SAMARAWICKRAMA C, LI H, et al. Retinal thickness in the offspring of diabetic pregnancies[J]. Am J Ophthalmol, 2010, 150(6): 883-887. doi: 10.1016/j.ajo.2010.06.036
[43]	LANDAU K, BAJKA J D, KIRCHSCHLÄGER B M. Topless optic disks in children of mothers with type I diabetes mellitus[J]. Am J Ophthalmol, 1998, 125(5): 605-611. doi: 10.1016/S0002-9394(98)00016-6
[44]	JIANG L, TANG K, MAGEE L A, et al. A global view of hypertensive disorders and diabetes mellitus during pregnancy[J]. Nat Rev Endocrinol, 2022, 18(12): 760-775. doi: 10.1038/s41574-022-00734-y
[45]	LINGHAM G, MACKEY D A, SANFILIPPO P G, et al. Influence of prenatal environment and birth parameters on amblyopia, strabismus, and anisometropia[J]. J APPOS, 2020, 24(2): 74. e1-74. e7.
[46]	ZHAO X, LI R, HUANG D, et al. Decreased retinal thickness in preschool offspring of maternal gestational hypertension: the Nanjing Eye Study[J]. Acta Ophthalmol, 2020, 98(6): e674-e679.
[47]	ÖZKAN H, CETINKAYA M, KOKSAL N, et al. Maternal preecl-ampsia is associated with an increased risk of retinopathy of prematurity[J]. J Perinat Med, 2011, 39(5): 523-527.
[48]	LI M, HUANG C, YANG W, et al. Evaluation of hypertensive disorder of pregnancy and high refractive error in offspring during childhood and adolescence[J]. JAMA Network Open, 2023, 6(4): e238694. doi: 10.1001/jamanetworkopen.2023.8694
[49]	GISHTI O, JADDOE V W V, FELIX J F, et al. Influence of maternal angiogenic factors during pregnancy on microvascular structure in school-age children[J]. Hypertension, 2015, 65(4): 722-728. doi: 10.1161/HYPERTENSIONAHA.114.05008
[50]	PHOSWA W N, KHALIQ O P. The role of oxidative stress in hypertensive disorders of pregnancy (preeclampsia, gestational hypertension) and metabolic disorder of pregnancy (gestational diabetes mellitus)[J]. Oxid Med Cell Longev, 2021, 2021: 5581570. doi: 10.1155/2021/5581570
[51]	DIMITRIADIS E, ROLNIK D L, ZHOU W, et al. Pre-eclampsia[J]. Nat Rev Dis Primers, 2023, 9(1): 8. doi: 10.1038/s41572-023-00417-6
[52]	MCGLONE L, MACTIER H, WEAVER L T. Drug misuse in pregnancy: losing sight of the baby?[J]. Arch Dis Child, 2009, 94(9): 708-712. doi: 10.1136/adc.2008.156851
[53]	CIUCÃ ANGHEL D M, NITESCU G V, TIRON A T, et al. Understanding the mechanisms of action and effects of drugs of abuse[J]. Molecules, 2023, 28(13): 4969. doi: 10.3390/molecules28134969
[54]	AUGER N, RHÉAUME M, LOW N, et al. Impact of prenatal exposure to opioids, cocaine, and cannabis on eye disorders in children[J]. J Addict Med, 2020, 14(6): 459-466. doi: 10.1097/ADM.0000000000000621
[55]	GILL A, OEI J, LEWIS N, et al. Strabismus in infants of opiate-dependent mothers[J]. Acta Paediatr, 2007, 92(3): 379-385.
[56]	ASLAKSEN A K, VIKESDAL G H, VOIE M T, et al. Visual function in Norwegian children aged 5-13 years with prenatal exposure to opioid maintenance therapy: a case-control study[J]. Acta Ophthalmol, 2024, 102(4): 409-420. doi: 10.1111/aos.15764
[57]	BLOCK S S, MOORE B D, SCHARRE J E. Visual anomalies in young children exposed to cocaine[J]. Optom Vis Sci, 1997, 74(1): 28-36. doi: 10.1097/00006324-199701000-00017
[58]	MCGLONE L, HAMILTON R, MCCULLOCH D L, et al. Neonatal visual evoked potentials in infants born to mothers prescribed methadone[J]. Pediatrics, 2013, 131(3): e857-e863. doi: 10.1542/peds.2012-2113
[59]	LIM Z W, CHEE M L, SOH Z D, et al. Six-year incidence of visual impairment in a multiethnic Asian population: the Singapore epidemiology of eye diseases study[J]. Ophthalmol Sci, 2023, 3(4): 100392. doi: 10.1016/j.xops.2023.100392
[60]	READ S A, COLLINS M J, CARNEY L G. A review of astigmatism and its possible genesis[J]. Clin Exp Optom, 2007, 90(1): 5-19. doi: 10.1111/j.1444-0938.2007.00112.x
[61]	DUBUCS C, N'GO V, CAILLET A, et al. The EFEMEREYE Study: prenatal medication exposure and ocular anomaly occurrence in EFEMERIS health database[J]. J AAPOS, 2024, 28(3): 103931. doi: 10.1016/j.jaapos.2024.103931
[62]	GÓMEZ-ROIG M D, PASCAL R, CAHUANA M J, et al. Environmental exposure during pregnancy: influence on prenatal development and early life: a comprehensive review[J]. Fetal Diagn Ther, 2021, 48(4): 245-257. doi: 10.1159/000514884
[63]	XIONG S, HE J, QIU H, et al. Maternal exposure to polystyrene nanoplastics causes defective retinal development and function in progeny mice by disturbing metabolic profiles[J]. Chemosphere, 2024, 352: 141513. doi: 10.1016/j.chemosphere.2024.141513