Association between subthreshold depression and psychotic-like experiences with non-suicidal self-injury among adolescents in Shandong Province
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摘要:
目的 探讨山东省青少年阈下抑郁和精神病性体验(PLEs)及其交互作用与非自杀性自伤(NSSI)行为的关联,为青少年NSSI的预防和早期干预提供参考依据。 方法 于2023年3—4月,采用分层整群随机抽样的方法,在山东省沿海和内陆分别各抽取2座城市中6 090名13~22岁大中学生施测。使用非自杀性自伤行为评定问卷、简式版社区心理体验评估问卷(CAPE-P8)、流调中心抑郁量表(CES-D)进行电子问卷调查,采用多因素Logistic回归分析青少年阈下抑郁和PLEs及其交互作用与NSSI的关联。 结果 青少年NSSI检出率为21.3%,单因素分析发现年龄在13~15岁青少年NSSI报告率最高(27.9%),有阈下抑郁和PLEs者NSSI报告率分别为49.9%,30.7%。多因素分析结果显示,存在阈下抑郁青少年发生NSSI的风险是无抑郁青少年的3.47倍[OR值(95%CI)=3.47(2.68~4.50)];有PLEs者发生NSSI的风险是未检出者的5.32倍[OR值(95%CI)=5.32(4.10~6.89)],阈下抑郁与PLEs同时存在时发生NSSI的风险是均未检出者的18.47倍[OR值(95%CI)=18.47(14.75~23.13)](P值均 < 0.01);超额危险度(RERI)、交互作用归因比(AP)和协同指数(S)分别为11.44, 0.61, 2.89,即阈下抑郁和PLEs对青少年NSSI的相加交互作用占比为61%。 结论 阈下抑郁和精神病性体验与青少年NSSI相关且存在相加交互作用。缓解青少年阈下抑郁并降低精神病性体验,对预防NSSI的发生具有积极作用。 Abstract:Objective To investigate the association between subthreshold depression, psychotic-like experiences (PLEs), and their interactions with non-suicidal self-injury (NSSI) in adolescents from Shandong, so as to provide a reference for the prevention and early intervention of NSSI in adolescents. Methods A random cluster sampling method was used to select a total of 6 090 adolescents aged 13-22 from two cities along the coast and inland of Shandong Province. Electronic surveys were administered using the Self-Injurious Behavior Questionnaire, Community Assessment of Psychic Experience-positive 8 items(CAPE-P8), and the Center for Epidemiological Studies Depression Scale(CES-D). The relationship between subthreshold depression, PLEs, and their interaction with NSSI was analyzed using multivariate Logistic regression. Results The detection rate of NSSI among adolescents was 21.3%. The highest NSSI reporting rate (27.9%) was found in the age group of 13-15 years.The NSSI reporting rates for those detected with subthreshold depression and PLEs were 49.9% and 30.7%, respectively. Multivariate analysis indicated that individuals with subthreshold depression were 3.47 times more likely to engage in NSSI [OR(95%CI)=3.47(2.68-4.50)]. Those identified with PLEs had 5.32 times higher risk of engaging in NSSI than those without such experiences [OR(95%CI)=5.32(4.10-6.89)]. When both subthreshold depression and PLEs coexist, the risk of engaging in NSSI was 18.47 times higher than in individuals with neither condition [OR(95%CI)=18.47(14.75-23.13)] (P < 0.01). The relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (S) were 11.44, 0.61, and 2.89, respectively, indicating that the combined interaction of subthreshold depression and PLEs accounted for 61% of adolescent NSSI. Conclusions Subthreshold depression and psychotic-like experiences are associated NSSI in adolescents and exhibit an additive interaction. Alleviating subthreshold depression in adolescents and reducing psychotic experiences may play a positive role in preventing the occurrence of NSSI. 1) 利益冲突声明 所有作者声明无利益冲突。 -
表 1 不同组别青少年NSSI报告率比较
Table 1. Comparison of NSSI reporting rates among different groups of adolescents
组别 选项 人数 NSSI人数 χ2值 P值 性别 男 3 849 827(21.5) 0.31 0.58 女 2 241 468(20.9) 年龄/岁 13~15 1 271 354(27.9) 42.33 <0.01 16~18 1 076 220(20.4) 19~22 3 743 721(19.3) 居住地 农村 3 473 710(20.4) 3.25 0.07 城镇 2 617 585(22.4) 独生子女 是 1 694 368(21.7) 0.29 0.59 否 4 396 927(21.1) 留守经历 是 335 103(30.7) 19.06 <0.01 否 5 755 1 192(20.7) 家庭结构 单亲 335 91(27.2) 7.65 0.06 双亲 4 335 914(21.1) 重组 127 26(20.5) 大家庭 1 293 264(20.4) 家庭月收入/元 <5 000 2 525 586(23.2) 10.17 <0.01 5 000~10 000 2 655 521(19.6) >10 000 910 188(20.7) 父母文化程度 高中及以下 5 230 1 094(20.9) 4.14 0.13 大学 772 176(22.8) 大学以上 88 25(28.4) PLEs 无 2 415 168(7.0) 489.33 <0.01 有 3 675 1 127(30.7) 抑郁状态 无 5 273 887(16.8) 463.39 <0.01 阈下抑郁 817 408(49.9) 注: ()内数字为报告率/%。 表 2 青少年阈下抑郁与PLEs与NSSI关联的Logistic回归分析(n=6 090)
Table 2. Logistic regression analysis of the association between subthreshold depression and PLEs with NSSI in adolescents (n=6 090)
自变量 选项 β值 标准误 Wald χ2值 P值 OR值(95%CI) PLEs 有 1.67 0.14 159.20 < 0.01 5.32(4.10~6.89) 阈下抑郁 有 1.24 0.20 88.29 < 0.01 3.47(2.68~4.50) PLEs×阈下抑郁 0.09 0.05 0.47 0.49 0.91(0.70~1.18) 阈下抑郁+PLEs 有阈下抑郁无PLEs 1.58 0.09 274.20 < 0.01 4.86(4.03~5.86) 无阈下抑郁有PLEs 1.15 0.25 21.26 < 0.01 1.94(1.94~5.17) 有阈下抑郁有PLEs 2.91 0.11 646.08 < 0.01 18.47(14.75~23.13) 注:相加交互项以“无阈下抑郁无PLEs”为参照。 -
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