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儿童青少年新型冠状病毒感染流行病学研究进展

秦阳 董彦会 谢俊卿 苏彬彬 宋逸 马军

秦阳, 董彦会, 谢俊卿, 苏彬彬, 宋逸, 马军. 儿童青少年新型冠状病毒感染流行病学研究进展[J]. 中国学校卫生, 2024, 45(1): 142-147. doi: 10.16835/j.cnki.1000-9817.2024022
引用本文: 秦阳, 董彦会, 谢俊卿, 苏彬彬, 宋逸, 马军. 儿童青少年新型冠状病毒感染流行病学研究进展[J]. 中国学校卫生, 2024, 45(1): 142-147. doi: 10.16835/j.cnki.1000-9817.2024022
]QIN Yang, DONG Yanhui, XIE Junqing, SU Binbin, SONG Yi, MA Jun. Progress in the epidemiology of COVID-19 infections in children and adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(1): 142-147. doi: 10.16835/j.cnki.1000-9817.2024022
Citation: ]QIN Yang, DONG Yanhui, XIE Junqing, SU Binbin, SONG Yi, MA Jun. Progress in the epidemiology of COVID-19 infections in children and adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(1): 142-147. doi: 10.16835/j.cnki.1000-9817.2024022

儿童青少年新型冠状病毒感染流行病学研究进展

doi: 10.16835/j.cnki.1000-9817.2024022
基金项目: 

北京市教育科学"十四五"规划课题 3017-0009

详细信息
    作者简介:

    秦阳(2000-), 男, 广东广州人, 在读硕士, 主要研究方向为儿童慢性病和传染病

    通讯作者:

    董彦会, E-mail: dongyanhui@bjmu.edu.cn

  • 中图分类号: R181.3+2 R179 R193

Progress in the epidemiology of COVID-19 infections in children and adolescents

  • 摘要: 新型冠状病毒感染(COVID-19, 以下简称"新冠")大流行带来了一系列复杂的挑战, COVID-19在儿童青少年身上的病情通常不及成年人和老年人严重; 但在轻度或无症状的新冠之后, 一些儿童青少年也可能出现一系列严重并发症和不良健康影响。文章重点梳理儿童青少年新冠感染流行特征、健康影响、风险因素、防控措施和疫苗接种现状等, 以期为后续儿童青少年新冠疫情防控提供参考。
  • 表  1  各年龄段推荐的儿童新冠肺炎疫苗种类及有效性

    Table  1.   Recommended types and effectiveness of COVID-19 vaccines for children by age group

    年龄范围 疫苗种类 接种剂次 接种间隔 有效性
    6个月至4岁 Moderna 2 4~8周 6~23月儿童:51%;2~4岁:37%
    辉瑞/BioNTech 3 第2剂在第1剂后3周接种,第3剂在第2剂后8周接种 与年轻人相似
    5~11岁 Moderna 2 4~8周 与成人相似
    辉瑞/BioNTech 2 3~8周 91%
    6~11岁 CoronaVac(科兴) 2 第2剂接种后2周达到39.8%
    12~17岁 Moderna 2 4~8周 第2剂接种后2~14周内达到最高水平64.5%
    辉瑞/BioNTech(Comirnaty) 3 3~8周 与成人相似, 在12~15岁年龄组的重度感染方面具有100%功效,在≥16岁人群预防重症的有效性为91%。仅注射2针对住院治疗总体有效性为94%,对入住ICU有效性为98%
    Novavax 2 3周 78%
    3~17岁 BBIBP-CorV(北京生物) 3 4周 具有可接受的安全性,并且能够引发强烈的免疫反应(1/2期临床试验)
    下载: 导出CSV
  • [1] PATHAK E B, SALEMI J L, SOBERS N, et al. COVID-19 in children in the United States: intensive care admissions, estimated total infected, and projected numbers of severe pediatric cases in 2020[J]. J Public Health Manage Pract, 2020, 26(4): 325-333. doi: 10.1097/PHH.0000000000001190
    [2] CHOW E J, ENGLUND J A. Severe acute respiratory syndrome coronavirus 2 infections in children[J]. Infect Dis Clin North Am, 2022, 36(2): 435-479. doi: 10.1016/j.idc.2022.01.005
    [3] Children and COVID-19 state-level data report[EB/OL]. (2023-05-11)[2023-11-15]. https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/.
    [4] DONG Y, MO X, HU Y, et al. Epidemiology of COVID-19 among children in China[J]. Pediatrics, 2020, 145(6): e20200702. doi: 10.1542/peds.2020-0702
    [5] DAWOOD F S, PORUCZNIK C A, VEGUILLA V, et al. Incidence rates, household infection risk, and clinical characteristics of SARS-CoV-2 infection among children and adults in Utah and New York City, New York[J]. JAMA Pediatr, 2022, 176(1): 59-67. doi: 10.1001/jamapediatrics.2021.4217
    [6] WIEGAND R E, DENG Y, DENG X, et al. Estimated SARS-CoV-2 antibody seroprevalence trends and relationship to reported case prevalence from a repeated, cross-sectional study in the 50 states and the district of Columbia, United States-October 25, 2020-February 26, 2022[J]. Lancet Reg Health Am, 2023, 18: 100403.
    [7] MARTIN B, DEWITT P E, RUSSELL S, et al. Characteristics, outcomes, and severity risk factors associated with SARS-CoV-2 infection among children in the US National COVID Cohort Collaborative[J]. JAMA Netw Open, 2022, 5(2): e2143151. doi: 10.1001/jamanetworkopen.2021.43151
    [8] SHARMA S, AGHA B, DELGADO C, et al. Croup associated with SARS-CoV-2: pediatric laryngotracheitis during the omicron surge[J]. J Pediatr Infect Dis Soc, 2022, 11(8): 371-374. doi: 10.1093/jpids/piac032
    [9] BREWSTER R C, PARSONS C, LAIRD-GION J, et al. COVID-19-associated croup in children[J]. Pediatrics, 2022, 149(6): e2022056492. doi: 10.1542/peds.2022-056492
    [10] PRICE A M, OLSON S M, NEWHAMS M M, et al. BNT162b2 protection against the Omicron variant in children and adolescents[J]. N Engl J Med, 2022, 386(20): 1899-1909. doi: 10.1056/NEJMoa2202826
    [11] OLSON S M, NEWHAMS M M, HALASA N B, et al. Effectiveness of pfizer-biontech mrna vaccination against COVID-19 hospitalization among persons aged 12-18 years-United States, June-September 2021[J]. Morb Mortal Wkly Rep, 2021, 70(42): 1483-1488. doi: 10.15585/mmwr.mm7042e1
    [12] 国务院应对新型冠状病毒感染疫情联防联控机制综合组. 关于印发应对近期新冠病毒感染疫情疫苗接种工作方案的通知[EB/OL]. (2023-04-10)[2023-11-15]. https://www.gov.cn/lianbo/2023-04/10/content_5750733.htm.

    Joint Prevention and Control Mechanism of the State Council for Novel Coronavirus Infection of the PRC. Notice on the issuance of the work plan for vaccination in response to the recent outbreak of Novel Coronavirus infection[EB/OL]. (2023-04-10)[2023-11-15]. https://www.gov.cn/lianbo/2023-04/10/content_5750733.htm. (in Chinese)
    [13] DUAN L, SHAO X, WANG Y, et al. An investigation of mental health status of children and adolescents in China during the outbreak of COVID-19[J]. J Affect Disord, 2020, 275: 112-118. doi: 10.1016/j.jad.2020.06.029
    [14] CHUN J Y, JEONG H, KIM Y. Identifying susceptibility of children and adolescents to the Omicron variant[J]. BMC Med, 2022, 20(1): 451. doi: 10.1186/s12916-022-02655-z
    [15] WANG L, BERGER N A, KAELBER D C, et al. Incidence rates and clinical outcomes of SARS-CoV-2 infection with the omicron and delta variants in children younger than 5 years in the US[J]. JAMA Pediatr, 2022, 176(8): 811-813. doi: 10.1001/jamapediatrics.2022.0945
    [16] TORJESEN I. COVID-19: Omicron variant is linked to steep rise in hospital admissions of very young children[J]. BMJ, 2022, 376: O110.
    [17] SHI D S, WHITAKER M, MARKS K J, et al. Hospitalizations of children aged 5-11 years with laboratory-confirmed COVID-19-COVID-NET, 14 States, March 2020-February 2022[J]. Morb Mortal Wkly Rep, 2022, 71(16): 574-581. doi: 10.15585/mmwr.mm7116e1
    [18] MARKS K J, WHITAKER M, AGATHIS N T, et al. Hospitalization of infants and children aged 0-4 years with laboratory-confirmed COVID-19-COVID-NET, 14 States, March 2020-February 2022[J]. Morb Mortal Wkly Rep, 2022, 71(11): 429-436. doi: 10.15585/mmwr.mm7111e2
    [19] SETIABUDI D, SRIBUDIANI Y, HERMAWAN K, et al. The Omicron variant of concern: the genomics, diagnostics, and clinical characteristics in children[J]. Front Pediatr, 2022, 10: 898463. doi: 10.3389/fped.2022.898463
    [20] CLOETE J, KRUGER A, MASHA M, et al. Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 Omicron (B. 1.1.529) variant wave in South Africa: a multicentre observational study[J]. Lancet Child Adolesc health, 2022, 6(5): 294-302. doi: 10.1016/S2352-4642(22)00027-X
    [21] MENSAH A A, CAMPBELL H, STOWE J, et al. Risk of SARS-CoV-2 reinfections in children: a prospective national surveillance study between January, 2020, and July, 2021, in England[J]. Lancet Child Adolesc Health, 2022, 6(6): 384-392. doi: 10.1016/S2352-4642(22)00059-1
    [22] MARTIN B, DEWITT P E, RUSSELL S, et al. Acute upper airway disease in children with the Omicron (B. 1.1.529) variant of SARS-CoV-2: a report from the US National COVID cohort collaborative[J]. JAMA Pediatr, 2022, 176(8): 819-821. doi: 10.1001/jamapediatrics.2022.1110
    [23] BAHL A, MIELKE N, JOHNSON S, et al. Severe COVID-19 outcomes in pediatrics: an observational cohort analysis comparing Alpha, Delta, and Omicron variants research in context[J]. Lancet Region Health Am, 2023, 18: 100405. doi: 10.1016/j.lana.2022.100405
    [24] HOLM M, ESPENHAIN L, GLENTHØJ J, et al. Risk and phenotype of multisystem inflammatory syndrome in vaccinated and unvaccinated danish children before and during the Omicron wave[J]. JAMA Pediatr, 2022, 176(8): 821-823. doi: 10.1001/jamapediatrics.2022.2206
    [25] YU W, GUO Y, ZHANG S, et al. Proportion of asymptomatic infection and nonsevere disease caused by SARS-CoV-2 Omicron variant: a systematic review and analysis[J]. J Med Virol, 2022, 94(12): 5790-5801. doi: 10.1002/jmv.28066
    [26] KARRON R A, HETRICH M K, NA Y B, et al. Assessment of clinical and virological characteristics of SARS-CoV-2 infection among children aged 0 to 4 years and their household members[J]. JAMA Network Open, 2022, 5(8): e2227348. doi: 10.1001/jamanetworkopen.2022.27348
    [27] 卞相丽, 国志, 张坤, 等. 上海380例家庭聚集性感染Omicron变异株的儿童及其家属临床特征分析[J]. 中国当代儿科杂志, 2022, 24(10): 1085-1091.

    BIAN X L, GUO Z, ZHANG K, et al. Clinical features of children and their family members with family clusters of SARS-Cov-2 Omicron variant infection in Shanghai, China: an analysis of 380 cases[J]. Chin J Contemp Pediatr, 2022, 24(10): 1085-1091. (in Chinese)
    [28] 桂明珠, 刘英丽, 丁阿凤, 等. 儿童新冠病毒Omicron株感染临床特征及其影响因素[J]. 临床儿科杂志, 2022, 40(10): 765-769.

    GUI M Z, LIU Y l, DING A F, et al, Clinical characteristics and influencing factors of SARS-CoV-2 Omicron variant infection in children[J]. J Clin Pediatr, 2022, 40(10): 765-769. (in Chinese)
    [29] NHS. Coronavirus (COVID-19) symptoms in children[EB/OL]. (2023-03-21)[2023-11-15]. https://www.nhs.uk/conditions/coronavirus-covid-19/symptoms/coronavirus-in-children/.
    [30] USA CDC. Information for pediatric healthcare providers[EB/OL]. (2023-03-11)[2023-11-15]. https://www.cdc.gov/coronavirus/2019-ncov/hcp/pediatric-hcp.html.
    [31] WHO. COVID-19 disease in children and adolescents: scientific brief[EB/OL]. (2021-09-29)[2023-11-15]. https://www.who.int/publications/i/item/WHO-2019-nCoV-Sci_Brief-Children_and_adolescents-2021.1.
    [32] WHO. Interim statement on COVID-19 vaccination for children[EB/OL]. (2022-08-11)[2023-11-15]. https://www.who.int/news/item/11-08-2022-interim-statement-on-covid-19-vaccination-for-children.
    [33] European Center for Disease Control. Clinical characteristics of COVID-19[EB/OL]. (2023-05-30)[2023-11-15]. https://www.ecdc.europa.eu/en/covid-19/latest-evidence/clinical.
    [34] AYOUBKHANI D, PAWELEK P. Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 1 April 2021[Z]. 2021-04-01.
    [35] FELDSTEIN L R, ROSE E B, HORWITZ S M, et al. Multisystem inflammatory syndrome in US children and adolescents[J]. New Engl J Med, 2020, 383(4): 334-346. doi: 10.1056/NEJMoa2021680
    [36] JIANG L, TANG K, LEVIN M, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents[J]. Lancet Infect Dis, 2020, 20(11): e276-e288. doi: 10.1016/S1473-3099(20)30651-4
    [37] MILSTONE A. COVID in babies and kids: symptoms and prevention[Z/OL]. (2022-06-22)[2023-11-15]. https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/coronavirus-in-babies-and-children.
    [38] FELDSTEIN L R, TENFORDE M W, FRIEDMAN K G, et al. Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19[J]. JAMA, 2021, 325(11): 1074-1087. doi: 10.1001/jama.2021.2091
    [39] CHOU J, THOMAS P G, RANDOLPH A G. Immunology of SARS-CoV-2 infection in children[J]. Nat Immunol, 2022, 23(2): 177-185. doi: 10.1038/s41590-021-01123-9
    [40] WANG W Y, WANG Y J, AN C X, et al. Multisystem inflammatory syndrome (MIS-C) with SARS-CoV-2 Omicron variant BA. 2.38 in a four-year-old Chinese girl: a case report[J]. Front Public Health, 2022, 10: 1021200. doi: 10.3389/fpubh.2022.1021200
    [41] PIERCE C A, HEROLD K C, HEROLD B C, et al. COVID-19 and children[J]. Science, 377(6611): 1144-1149. doi: 10.1126/science.ade1675
    [42] ROBERTON T, CARTER E D, CHOU V B, et al. Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study[J]. Lancet Global Health, 2020, 8(7): e901-e908. doi: 10.1016/S2214-109X(20)30229-1
    [43] STEIN D, WARD K, CANTELMO C. Estimating the potential impact of COVID-19 on mothers and newborns in low- and middle-income countries[Z/OL]. (2020-04-16)[2023-11-15]. https://propel-health-project.medium.com/estimating-the-potential-impact-of-covid-19-on-mothers-and-newborns-in-low-and-middle-income-3a7887e4a0ff.
    [44] MENENDEZ C, GONZALEZ R, DONNAY F, et al. Avoiding indirect effects of COVID-19 on maternal and child health[J]. Lancet Global Health, 2020, 8(7): e863-e864. doi: 10.1016/S2214-109X(20)30239-4
    [45] LÓPEZ-BUENO R, LÓPEZ-SÁNCHEZ G F, CASAJúS J A, et al. Health-related behaviors among school-aged children and adolescents during the Spanish COVID-19 confinement[J]. Front Pediatr, 2020, 8: 573. doi: 10.3389/fped.2020.00573
    [46] 谢辉, 王菁菁, 杨金柳行, 等. 新冠肺炎疫情初期上海市学龄儿童网课相关电子屏幕使用行为及影响因素分析[J]. 中国学校卫生, 2022, 43(3): 341-344. doi: 10.16835/j.cnki.1000-9817.2022.03.006

    XIE H, WANG J J, YANG J L X, et al. Online learning-related screen use and associated factors in school-aged children in Shanghai during the COVID-19 epidemic[J]. Chin J Sch Health, 2022, 43(3): 341-344. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2022.03.006
    [47] CHANG T H, CHEN Y C, CHEN W Y, et al. Weight gain associated with COVID-19 lockdown in children and adolescents: a systematic review and Meta-analysis[J]. Nutrients, 2021, 13: 3668. doi: 10.3390/nu13103668
    [48] WHO. WHO director-general's opening remarks at the media briefing on COVID-19-28 February 2020[EB/OL]. (2020-02-28)[2023-11-15]. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19--8-february-2020.
    [49] UCICEF. The impact of COVID-19 on children's mental health[EB/OL]. (2021-06-23)[2023-11-15]. https://www.unicef.org/india/impact-covid-19-childrens-mental-health.
    [50] BEHERE A, BARBER GARCIA B N. COVID-19 and children's mental health: identifying challenges and the New Normal[J]. Curr Pediatr Rev, 2021, 17(3): 185-190. doi: 10.2174/1573396317666210514172829
    [51] CASPI A, HARRINGTON H L, MOFFITT T E, et al. Socially isolated children 20 years later: risk of cardiovascular disease[J]. Arch Pediatr Adolesc Med, 2006, 8: 805-811.
    [52] BICK J, LUYSTER R, FOX N A, et al. Effects of early institutionalization on emotion processing in 12-year-old youth[J]. Dev Psychopathol, 2017, 29: 1749-1761. doi: 10.1017/S0954579417001377
    [53] YOUNG A, LUYSTER R J, FOX N A, et al. The effects of early institutionalization on emotional face processing: evidence for sparing via an experience-dependent mechanism[J]. Br J Dev Psychol, 2017, 35: 439-453. doi: 10.1111/bjdp.12185
    [54] YANG Z, LUO Y, ZHOU Q, et al. COVID-19-related stressors and depression in Chinese adolescents: the effects of life history strategies and gender[J]. J Affect Disord, 2022, 304: 122-127. doi: 10.1016/j.jad.2022.02.060
    [55] SPRANG G, SILMAN M. Posttraumatic stress disorder in parents and youth after health-related disasters[J]. Disaster Med Public Health Prep, 2013, 7(1): 105-110. doi: 10.1017/dmp.2013.22
    [56] DE HOOG M L A, SLUITER-POST J G C, WESTERHOF I, et al. Longitudinal household assessment of respiratory illness in children and parents during the COVID-19 pandemic[J]. JAMA Netw Open, 2022, 5(10): e2237522. doi: 10.1001/jamanetworkopen.2022.37522
    [57] SIEBACH M K, PIEDIMONTE G, LEY S H. COVID-19 in childhood: transmission, clinical presentation, complications and risk factors[J]. Pediatr Pulmonol, 2021, 56(6): 1342-1356. doi: 10.1002/ppul.25344
    [58] WATERFIELD T, WATSON C, MOORE R, et al. Seroprevalence of SARS-CoV-2 antibodies in children: a prospective multicentre cohort study[J]. Arch Dis Child, 2021, 106(7): 680-686. doi: 10.1136/archdischild-2020-320558
    [59] ISMAIL S A, SALIBA V, LOPEZ BERNAL J, et al. SARS-CoV-2 infection and transmission in educational settings: a prospective, cross-sectional analysis of infection clusters and outbreaks in England[J]. Lancet Infect Dis, 2021, 21(3): 344-353. doi: 10.1016/S1473-3099(20)30882-3
    [60] MACARTNEY K, QUINN H E, PILLSBURY A J, et al. Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study[J]. Lancet Child Adolesc Health, 2020, 4(11): 807-816. doi: 10.1016/S2352-4642(20)30251-0
    [61] LEON-ABARCA J A. Obesity and immunodeficiencies are the main pre-existing conditions associated with mild to moderate COVID-19 in children[J]. Pediatr Obes, 2020, 15(12): e12713. doi: 10.1111/ijpo.12713
    [62] SKEVAKI C, KARSONOVA A, KARAULOV A, et al. SARS-CoV-2 infection and COVID-19 in asthmatics: a complex relationship[J]. Nature Rev Immunol, 2021, 21(4): 202-203. doi: 10.1038/s41577-021-00516-z
    [63] JEFFERSON T, DEL MAR C, DOOLEY L, et al. Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review[J]. BMJ, 2009, 339: b3675. doi: 10.1136/bmj.b3675
    [64] ESPOSITO S, PRINCIPI N. To mask or not to mask children to overcome COVID-19[J]. Eur J Pediatr, 2020, 179(8): 1267-1270. doi: 10.1007/s00431-020-03674-9
    [65] CHEN X, RAN L, LIU Q, et al. Hand hygiene, mask-wearing behaviors and its associated factors during the COVID-19 epidemic: a cross-sectional study among primary school students in Wuhan, China[J]. Int J Environ Res Public Health, 2020, 17(8): 2893. doi: 10.3390/ijerph17082893
    [66] LUBY S, AGBOATWALLA M, FEIKIN D, et al. Effect of handwashing on child health: a randomised controlled trial[J]. Lancet, 2005, 366(9481): 225-233. doi: 10.1016/S0140-6736(05)66912-7
    [67] CURTIS V, CAIRNCROSS S. Effect of washing hands with soap on diarrhoea risk in the community: a systematic review[J]. Lancet Infect Dis, 2003, 3(5): 275-281. doi: 10.1016/S1473-3099(03)00606-6
    [68] LUBY S, HALDER A, HUDA T, et al. The effect of handwashing at recommended times with water alone and with soap on child diarrhea in rural Bangladesh: an observational study[J]. PLoS Med, 2011, 8(6): e1001052. doi: 10.1371/journal.pmed.1001052
    [69] Mayo Clinic Staff. COVID-19 in babies and children[EB/OL]. (2023-11-03)[2023-11-15]. https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-in-babies-and-children/art-20484405.
    [70] National Health Service. COVID-19 vaccination programme for children and young people: guidance for parents (version 3)[EB/OL]. (2022-01-19)[2023-11-15]. https://www.gov.uk/government/publications/covid-19-vaccination-resources-for-schools/covid-19-vaccination-programme-for-young-people-guidance-for-parents.
    [71] POWELL A A, KIRSEBOM F, STOWE J, et al. Protection against symptomatic infection with Delta (B. 1.617.2) and Omicron (B. 1.1.529) BA. 1 and BA. 2 SARS-CoV-2 variants after previous infection and vaccination in adolescents in England, August, 2021-March, 2022: a national, observational, test-negative, case-control study[J]. Lancet Infect Dis, 2023, 23(4): 435-444. doi: 10.1016/S1473-3099(22)00729-0
    [72] OLSON S M, NEWHAMS M M, HALASA N B, et al. Effectiveness of BNT162b2 vaccine against critical COVID-19 in adolescents[J]. New Engl J Med, 2022, 386(8): 713-723. doi: 10.1056/NEJMoa2117995
    [73] CDC, NCIRD, Division of Viral Diseases. COVID-19 vaccines for children and teens[EB/OL]. (2021-05-27)[2023-01-15]. https://wwwcdcgov/coronavirus/2019-ncov/vaccines/recommendations/adolescentshtml.
    [74] IMMUNIZATION N A C O. Recommendations on the use of COVID-19 vaccines[EB/OL]. (2021-10-22)[2023-01-15]. https://wwwcanadaca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci/recommendations-use-covid-19-vaccineshtml, 2021.
    [75] ENGLAND P H. Joint committee on vaccination and immunisation issues advice on COVID-19 vaccination of children and young people[EB/OL]. (2021-07-19)[2023-11-15]. https://wwwgovuk/government/news/jcvi-issues-advice-on-covid-19-vaccination-of-children-and-young-people.
    [76] FLORENTINO P T V, ALVES F J O, CERQUEIRA-SILVA T, et al. Vaccine effectiveness of CoronaVac against COVID-19 among children in Brazil during the Omicron period[J]. Nat Commun, 2022, 13(1): 4756. doi: 10.1038/s41467-022-32524-5
    [77] XIA S, ZHANG Y, WANG Y, et al. Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in people younger than 18 years: a randomised, double-blind, controlled, phase 1/2 trial[J]. Lancet Infect Dis, 2022, 22(2): 196-208. doi: 10.1016/S1473-3099(21)00462-X
    [78] WALLACE M, OLIVER S. COVID-19 mRNA vaccines in adolescents and young adults: benefit-risk discussion[EB/OL]. (2021-06-23)[2023-01-15]. https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-06/05-COVID-Wallace-508.pdf.
    [79] WILKINSON D, FINLAY I, POLLARD A, et al. Should we delay Covid-19 vaccination in children?[J]. BMJ (Clin Res), 2021, 374: n1687.
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出版历程
  • 收稿日期:  2023-05-02
  • 修回日期:  2023-11-15
  • 网络出版日期:  2024-02-01
  • 刊出日期:  2024-01-25

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