铜仁市2018—2022年手足口病流行病学及病原学特征分析

吴定国; 余杨; 张俊丽; 高前荣

doi:10.16835/j.cnki.1000-9817.2023.12.029

铜仁市2018—2022年手足口病流行病学及病原学特征分析

doi: 10.16835/j.cnki.1000-9817.2023.12.029

吴定国^{1, 2},
余杨¹,
张俊丽¹,
高前荣^1, ,

1.
贵州省铜仁市疾病预防控制中心流行病防治科，554300
2.
铜仁市现场流行病学培训项目1期

基金项目: 2018—2022年中央补助地方重大传染病防治项目

详细信息

作者简介:
吴定国(1983-)，男，贵州省黄平人，大学本科，主管技师，主要从事传染病防控工作

通讯作者:
高前荣，E-mail: 578527505@qq.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R181.3⁺² R511 R179
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- PDF下载量: 51
- 被引次数: 0
出版历程
- 收稿日期: 2023-05-15
- 修回日期: 2023-10-09
- 网络出版日期: 2023-12-26
- 刊出日期: 2023-12-25

Epidemiological and etiological characteristics of hand-foot-mouth disease in Tongren City from 2018 to 2022

WU Dingguo^{1, 2},
YU Yang¹,
ZHANG Junli¹,
GAO Qianrong^{1
, ,}

1.
Tongren Disease Control and Prevention Center, Tongren (554300), Guizhou Province, China

摘要

摘要: 目的分析2018—2022年铜仁市手足口病(HFMD)流行病学及病原学特征，为有效防控手足口病提供参考依据。方法从国家传染病报告信息管理系统中收集2018—2022年铜仁市手足口病监测数据，采用描述性流行病学方法对数据进行统计学分析。结果 2018—2022年铜仁市累计报告手足口病14 376例，年均报告发病率为89.43/10万，重症病例47例，占病例总数的0.33%。2018—2022年发病率(124.68/10万，95.37/10万，78.50/10万，61.63/10万，87.80/10万)总体呈下降趋势(χ_趋势²=393.05，P＜0.01)，发病主要集中在4—7月(48.13%)；发病年龄以5岁及以下儿童为主(95.72%)。2018—2022年累计报告实验室诊断病例967例，不同年份、地区、年龄组病原体构成比差异有统计学意义(χ²值分别为169.62，456.65，167.96，P值均＜0.05)。2018—2022年铜仁市手足口病的优势病原在不断变化，2018及2022年主要以其他肠道病毒为优势流行株(33.04%，37.62%)，2019—2020年以CoxA6为优势流行株(68.75%，50.78%)，2021年以CoxA16为优势流行株(43.30%)。2018年有1例合并有CoxA16、EV71感染。不同年份各病原构成比差异均有统计学意义(χ²=169.62，P＜0.01)。结论 2018—2022年铜仁市手足口病发病率总体呈下降趋势，优势毒株近年来有所变化。应加强手足口病病原监测，及时掌握病原分布及变化情况，为手足口病精准防控提供依据。
- 手足口病 /
- 发病率 /
- 流行病学研究 /
- 儿童
Abstract: Objective To analyze the epidemiological and etiological characteristics of hand-foot-mouth disease (HFMD) in Tongren City during 2018 to 2022, so as to provide the reference for HFMD effective prevention and control. Methods Monitoring data on HFMD in Tongren City from 2018 to 2022 was collected from National Infectious Disease Reporting Information Management System. Descriptive epidemiological method was conducted on the data analysis. Results A total of 14 376 cases of HFMD were reported in Tongren City during 2018 to 2022, the average annual incidence rate of HFMD was 89.43/100 000. Totally 47 severe cases were reported, accounting for 0.33% of the total cases. The incidence rates of HFMD were generally declining trend during 2018 to 2022 (124.68/100 000, 95.37/100 000, 78.50/100 000, 61.63/100 000, 87.80/100 000) (χ_trend²=393.05, P < 0.01), mainly occurred during April to July (48.13%), among children under 5 years old (95.72%). During 2018 to 2022, a total of 967 laboratory diagnosed cases reported in different years, regions, age groups showed significant differences in pathogen composition ratio (χ²=169.62, 456.65, 167.96, P < 0.05). From 2018 to 2022, the dominant pathogen of HFMD was constantly changing. Other enteroviruses were the dominant epidemic strains in 2018 and 2022 (33.04%, 37.62%), CoxA 6 was the dominant epidemic strain in 2019 to 2020 (68.75%, 50.78%), and CoxA16 was the dominant epidemic strain in 2021(43.30%).In 2018, one case was infected with CoxA16 and EV71.The difference of pathogen composition ratio varied in different years (χ²=169.62, P < 0.01). Conclusions The prevalence of HFMD in Tongren City has showed a declining trend during 2018 to 2022, and the dominant strain of HFMD has changed in recent years. The pathogen monitoring of HFMD should be strengthened to timely grasp the distribution and changes of pathogens, so as to provide a basis for the precise prevention and control of HFMD.
- Hand, foot and mouth disease /
- Incidence /
- Epidemiologic studies /
- Child
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

HTML全文

图 1 铜仁市2018—2022年手足口病病例发病时间分布

Figure 1. Distribution of incidence time of HFMD cases in Tongren City from 2018 to 2022

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表 2 铜仁市2018—2022年手足口病病例病原学检测结果分布

Table 2. Etiological detection results of HFMD cases in Tongren City from 2018 to 2022

年份	病毒阳性数	EV71	CoxA16	CoxA10	CoxA6	其他肠道病毒
2018	339	1(0.29)	103(30.38)	46(13.57)	78(23.01)	112(33.04)
2019	128	0	15(11.72)	3(2.34)	88(68.75)	22(17.19)
2020	193	10(5.18)	37(19.17)	9(4.66)	98(50.78)	39(20.21)
2021	97	2(2.06)	42(43.30)	1(1.03)	21(21.65)	31(31.96)
2022	210	3(1.43)	52(24.76)	13(6.19)	63(30.00)	79(37.62)
合计	967	16(1.65)	249(25.75)	72(7.45)	348(35.99)	283(29.27)
注： ()内数字为构成比/%。

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