内蒙古中小学生血清维生素D水平与糖脂代谢的相关性

李乐慧; 张星光; 方鑫; 曹宁; 苏志刚; 闫涛; 张楠

doi:10.16835/j.cnki.1000-9817.2023.12.021

内蒙古中小学生血清维生素D水平与糖脂代谢的相关性

doi: 10.16835/j.cnki.1000-9817.2023.12.021

内蒙古医科大学公共卫生学院，呼和浩特 010110

基金项目:

内蒙古自治区高校教育厅自然科学一般项目 NJZY22645

内蒙古自治区自然科学基金项目 2023QN08030

内蒙古医科大学面上项目 YKD2022MS079

详细信息

作者简介:
李乐慧(1985-)，女，内蒙古呼和浩特人，硕士，讲师，主要研究方向为心血管流行病学

通讯作者:
闫涛，E-mail: yantao715lynn@126.com

张楠，E-mail: 17704713193@163.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R153.2 R591.44 R364.2
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- 被引次数: 0
出版历程
- 收稿日期: 2023-06-26
- 修回日期: 2023-09-19
- 网络出版日期: 2023-12-26
- 刊出日期: 2023-12-25

Correlation between serum vitamin D level and glucose and lipid metabolism among primary and middle school students in Inner Mongolia

School of Public Health, Inner Mongolia Medical University, Hohhot (010110), Inner Mongolia Autonomous Region, China

摘要

摘要: 目的探讨内蒙古中小学生血清维生素D水平与糖脂代谢的相关性，为指导中小学生合理补充维生素D提供科学依据。方法采用多阶段分层随机抽样，选取内蒙古的8个旗县2 206名中小学生进行问卷调查、体格检查和实验室检测。分析不同维生素D水平下空腹血糖、血脂等相关指标的水平，并进一步探讨其与空腹血糖、血脂代谢的相关性。结果中小学生维生素D缺乏和不足率分别为33.2%和42.8%，维生素D适宜率为24.0%。维生素D缺乏组的体质量指数(BMI)及腰围身高比(WHtR)[(22.87±7.41)kg/m²，0.46±0.08]高于不足组和适宜组[(20.59±8.00，18.01±7.38)kg/m²，(0.44±0.09，0.43±0.08)(P值均 < 0.05)。与维生素D适宜组比较[(3.87±0.85)mmol/L]，缺乏组总胆固醇(TC)的水平[(3.73±0.67)mmol/L]降低，差异有统计学意义(P < 0.05)。维生素D不足组和缺乏组的高密度脂蛋白胆固醇(HDL)水平[(1.40±0.33，1.34±0.31)mmol/L]均低于适宜组[(1.48±0.34)mmol/L]，差异有统计学意义(P值均 < 0.05)。维生素D缺乏组的高尿酸血症(HUA)检出率高于适宜组(22.95%，17.20%)，差异有统计学意义(P < 0.016 7)。Pearson相关分析显示，维生素D与BMI、WHtR均呈负相关(r值分别为-0.23，-0.11)，与TC、HDL水平均呈正相关(r值分别为0.06，0.16)(P值均 < 0.05)。结论内蒙古中小学生血清维生素D缺乏和不足率较高，维生素D水平影响血脂部分指标，需要适量补充维生素D制剂。
- 维生素D /
- 血糖 /
- 血脂 /
- 代谢 /
- 学生 /
- 少数民族
Abstract: Objective To explore the correlation between serum vitamin D level and glucose and lipid metabolism among primary and middle school students in Inner Mongolia, so as to providing a scientific basis for guiding rational vitamin D supplementation among primary and middle school students in Inner Mongolia Region. Methods A total of 2 206 students of primary and middle school students from 8 counties (districts) in Inner Mongolia were enrolled for a questionnaire survey, physical examination, and laboratory test by a multi-stage stratified random sampling approach.The levels of fasting blood glucose, blood lipid and other related indexes with different vitamin D levels were analyzed, and their correlation was further discussed. Results The deficiency and insufficiency rates of vitamin D among primary and middle school students were 33.2% and 42.8%, respectively, and the suitable rate was 24.0%. The body mass index (BMI) and waist-height ratio (WHtR) of the vitamin D deficiency group [(22.87±7.41)kg/m², 0.46±0.08)]were higher than the insufficiency [(20.59±8.00)kg/m², 0.44±0.09)] and suitable group [(18.01±7.38)kg/m², 0.43±0.08)] (P < 0.05). Compared with the vitamin D suitable group [(3.87±0.85) mmol/L], the total cholesterol (TC) level in the deficiency group [(3.73±0.67)mmol/L] decreased, with a statistically significant difference (P < 0.05). The levels of high density lipoproteins (HDL) in the vitamin D insufficiency[(1.40±0.33)mmol/L] and deficiency groups [(1.34±0.31)mmol/L] were lower than the suitable group [(1.48±0.34)mmol/L], with a statistically significant difference (P < 0.05). The detection rate of hyperuricemia (HUA) in the vitamin D deficiency group (22.95%) was higher than the suitable group (17.20%), with a statistically significant difference (P < 0.016 7). Pearson correlation analysis showed that vitamin D was negatively correlated with BMI and WHtR (r=-0.23, -0.11), and positively correlated with TC and HDL level (r=0.06, 0.16) (P < 0.05). Conclusions The deficiency and insufficiency rates of serum vitamin D among primary and middle school students in Inner Mongolia are high which are associated with several indicators of blood lipids. Therefore, it is recommended to supplement vitamin D preparations in moderation in daily life.
- Vitamin D /
- Blood glucose /
- Blood lipids /
- Metabolism /
- Students /
- Minority groups
注释:

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表 1 不同维生素D营养状况组学生BMI、WHtR、FPG、SUA及血脂水平比较(x±s)

Table 1. Comparison of BMI, WHtR, blood glucose, uric acid and lipid levels of students in different Vitamin D nutritional status groups(x±s)

组别	人数	BMI/ (kg·m^-2)	WHtR	FPG/ (mmol·L^-1)	SUA/ (μmol·L^-1)	血脂水平/(mmol·L^-1)
组别	人数	BMI/ (kg·m^-2)	WHtR	FPG/ (mmol·L^-1)	SUA/ (μmol·L^-1)	TC	TG	HDL	LDL
适宜	529	18.01±7.38	0.43±0.08	5.20±0.46	322.43±85.73	3.87±0.85	0.88±0.45	1.48±0.34	1.97±0.68
不足	945	20.59±8.00^*	0.44±0.09^*	5.13±0.50	318.05±86.30	3.78±0.79	0.87±0.43	1.40±0.33^*	1.98±0.69
缺乏	732	22.87±7.41^*#	0.46±0.08^*#	5.14±0.61	324.83±87.12	3.73±0.67^*	0.91±0.41	1.34±0.31^*#	1.92±0.58
F值		62.28	16.01	2.63	1.32	4.81	1.83	28.59	1.65
P值		< 0.01	< 0.01	0.07	0.27	0.01	0.16	< 0.01	0.19
注：*与适宜组比较，P < 0.05；#与不足组比较，P < 0.05。

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表 2 不同维生素D营养状况组学生糖脂代谢异常率比较

Table 2. Comparison of abnormal rate of glucose and lipid metabolism of students in groups with different vitamin D nutritional status groups

组别	人数	血糖异常	血脂异常	HUA
适宜	529	12(2.27)	92(17.39)	91(17.20)
不足	945	24(2.54)	196(20.74)	189(20.00)
缺乏	732	18(2.46)	144(19.67)	168(22.95)^*
χ²值		0.11	2.42	6.37
P值		0.95	0.30	0.04
注：()内数字为检出率/%；*与适宜组比较，P < 0.016 7。

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