常州市2019-2022年学校札如病毒聚集性疫情的流行病学及病毒基因特征分析

姚萍; 李琼; 蒋霞; 毛旭建; 许健; 屠博文; 王凤鸣; 蒋靖怡

doi:10.16835/j.cnki.1000-9817.2023.10.030

常州市2019-2022年学校札如病毒聚集性疫情的流行病学及病毒基因特征分析

doi: 10.16835/j.cnki.1000-9817.2023.10.030

姚萍¹,
李琼¹,
蒋霞²,
毛旭建¹,
许健¹,
屠博文¹,
王凤鸣¹,
蒋靖怡^1, ,

1.
常州市疾病预防控制中心病原生物检验科，江苏 213022
2.
常州市疾病预防控制中心急性传染病防制科

基金项目:

常州市病原微生物学重点实验室 CM20223016

常州市卫生健康青苗人才项目 CZQM2022023

常州市科技支撑计划项目(社会发展) CE20225041

常州市科技计划项目(应用基础) CJ20220114

常州市科技计划项目(应用基础) CJ20200031

详细信息

作者简介:
姚萍(1981-)，女，江苏常州人，硕士，副主任技师，主要从事病原生物检验工作

通讯作者:
蒋靖怡，E-mail: 501jiangjingyi@163.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R181.3 R511 R179
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- 被引次数: 0
出版历程
- 收稿日期: 2023-05-08
- 修回日期: 2023-08-22
- 刊出日期: 2023-10-25

Epidemiological and genetic characteristics of sapovirus clusters in Changzhou schools from 2019 to 2022

1.
Pathogenic Biology Laboratory, Changzhou Center for Disease Control and Prevention, Changzhou(213022), Jiangsu Province, China

摘要

摘要: 目的了解常州市学校札如病毒(SaV)聚集性疫情的流行病学及病毒基因特征，为学校处置聚集性呕吐腹泻事件提供参考。方法收集2019—2022年常州市SaV聚集性疫情的流行病学资料和实验室检测数据进行流行病学分析，对SaV阳性样本进行VP1部分基因扩增和测序，并进行系统进化分析。结果 2019—2022年常州市中小学及幼儿园共报告SaV聚集性疫情8起，报告病例数118例，总罹患率为1.47%，罹患人数中位数为15例。疫情流行时间集中在9—12月，场所分布为幼儿园6起，小学2起；主要临床表现为呕吐(113例，95.76%)、腹痛(39例，33.05%)、腹泻(16例，13.56%)。8起疫情中17株样本株测序成功，其中5起疫情由GII.3基因型引起，另外3起分别为GI.1、GI.3和GII.2。GI和GII是本地区主要型别，GII.3为聚集性疫情流行优势株。结论 SaV是学校聚集性呕吐腹泻疫情中的重要病原体，应对其进行持续监测，进一步了解其流行特征及病毒基因型分布情况，为学校疫情防控提供科学依据。
- 肠道病毒感染 /
- 疾病暴发流行 /
- 发病率 /
- 基因 /
- 病毒
Abstract: Objective To analyze the epidemiological characteristics and genetic characteristics of sapovirus (SaV) in a cluster of schools in Changzhou, so as to provide a reference for the treatment of clustered vomiting and diarrhea events in schools. Methods The epidemiological data and laboratory test data of sapovirus clusters in Changzhou from 2019 to 2022 were collected and analyzed. Partial VP1 genes of SaV positive samples were amplified and sequenced for phylogenetic analysis. Results A total of 8 cases of clusters of SaV epidemics were reported in Changzhou City from 2019 to 2022, with 118 reported cases. The total attack rate was 1.47%, and the median of the attack number was 15. There were 6 outbreaks in kindergartens and 2 outbreaks in primary schools, which were reported in the epidemic period from September to December. The main clinical manifestations were vomiting (113 cases, 95.76%), abdominal pain (39 cases, 33.05%), and diarrhea (16 cases, 13.56%). Among the 8 outbreaks, 17 sample strains were successfully sequenced. 5 outbreaks were GII.3, and the other 3 outbreaks were GI.1, GI.3 and GII.2. GI and GII were the main genotypes in this area, and GII.3 was the predominant strain. Conclusion SaV is an important pathogen in the clusters of vomiting and diarrhea in schools after the transmission of norovirus. Continuous surveillance of SaV should be carried out to further understand its epidemiological characteristics and genotype distribution, so as to provide scientific basis for the prevention and control of the epidemic in schools.
- Enterovirus infections /
- Disease outbreaks /
- Incidence /
- Genes /
- Viruses
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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表 1 常州市2019—2022年札如病毒疫情基本情况

Table 1. Basic situation of SaV epidemic in Changzhou City from 2019 to 2022

年份	地区	临床特征				实验室检验		测序分型结果
年份	地区	病例数	呕吐	腹痛	腹泻	人数	阳性人数	测序分型结果
2019	武进区	17	17(100.00)	3(17.65)	2(11.76)	10	6(60.00)	GII.3
	天宁区	7	7(100.00)	0	0	7	2(28.57)	GII.3
	天宁区	11	8(72.73)	2(18.18)	2(18.18)	11	3(27.27)	GII.2
2020	新北区	8	7(87.50)	3(37.50)	2(25.00)	8	6(75.00)	GI.1
2021	武进区	17	16(94.12)	0	2(11.76)	14	11(78.57)	GII.3
	金坛区	21	21(100.00)	12(57.14)	3(14.29)	22	21(95.45)	GII.3
	金坛区	15	15(100.00)	2(13.33)	2(13.33)	19	6(31.58)	GI.3
2022	金坛区	22	22(100.00)	17(77.27)	3(13.64)	33	20(60.61)	GII.3
注：()内数字为检出率或阳性率/%。

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