深圳市中学生维生素D缺乏与焦虑抑郁症状的关联

赵梦雅; 许韶君; 李晓恒; 徐慧琼; 谌丁艳; 朱懿; 陶芳标

doi:10.16835/j.cnki.1000-9817.2023.07.016

深圳市中学生维生素D缺乏与焦虑抑郁症状的关联

doi: 10.16835/j.cnki.1000-9817.2023.07.016

1.
安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室，合肥 230032
2.
深圳市疾病预防控制中心学校卫生所

基金项目:

国家自然科学基金项目 82073578

安徽高校自然科学研究项目 KJ2020A0206

详细信息

作者简介:
赵梦雅(1997-)，女，安徽阜阳人，在读硕士，主要研究方向为儿童青少年卫生

通讯作者:
许韶君，E-mail：xushaojun@ahmu.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R591.44 G444 R179
计量
- 文章访问数: 283
- HTML全文浏览量: 120
- PDF下载量: 48
- 被引次数: 0
出版历程
- 收稿日期: 2023-03-07
- 修回日期: 2023-04-13
- 网络出版日期: 2023-07-25
- 刊出日期: 2023-07-25

Association of vitamin D deficiency with anxiety and depressive symptoms among middle school students in Shenzhen

1.
Department of Maternal with Child and Adolescent Health, School of Public Health, Anhui Medical University/Key Laboratory of Population Health across Life Cycle, Ministry of Education, Hefei(230032), China

摘要

摘要: 目的探讨深圳市中学生维生素D缺乏与焦虑、抑郁及焦虑抑郁共病症状的关联，为促进儿童青少年心理健康提供科学依据。方法 2021年10—12月，采用方便抽样选取深圳市4所中学1 323名初一和高一学生开展问卷调查和体格检查，采集空腹血检测维生素D水平。采用χ²检验和多因素Logistic回归模型分析中学生维生素D缺乏与焦虑、抑郁及焦虑抑郁共病症状的关联。结果中学生焦虑症状、抑郁症状、焦虑抑郁共病症状检出率分别为33.0%，21.5%，16.3%。调整混杂因素后，二元Logistic回归分析结果显示，中学生维生素D缺乏与焦虑症状(OR=1.59，95%CI=1.02~2.46)、抑郁症状(OR=1.94，95%CI=1.22~3.09)及焦虑抑郁共病症状(OR=1.75，95%CI=1.06~2.90)的风险均呈正相关(P值均＜0.05)。结论中学生维生素D缺乏与焦虑、抑郁及焦虑抑郁共病症状的增加相关，关联的方向性值得进一步研究。
- 维生素D缺乏 /
- 焦虑 /
- 抑郁 /
- 精神卫生 /
- 回归分析 /
- 学生
Abstract: Objective To explore the association of vitamin D deficiency with anxiety and depressive symptoms as well as their comorbidity, so as to provide references for improving the mental health of children and adolescents. Methods From October to December 2021, a total of 1 323 students from four middle schools in Shenzhen were selected by using convenience sampling method for a questionnaire survey and physical examination. Fasting blood samples were collected to detect vitamin D levels. The Chi-square test and multiple Logistic regression model were used to analyze the association of vitamin D deficiency with anxiety and depressive symptoms and their comorbidity among middle school students. Results The detection rates of anxiety, depressive, and thier comorbidities in middle school students were 33.0%, 21.5% and 16.3%, respectively. After adjusting for confounding factors, vitamin D deficiency was positively associated with the risk of anxiety symptoms (OR=1.59, 95%CI=1.02-2.46), depressive symptoms (OR=1.94, 95%CI=1.22-3.09) and anxiety-depressive co-morbid symptoms (OR=1.75, 95%CI=1.06-2.90) in secondary school students (P < 0.05). Conclusion Vitamin D deficiency is associated with an increased risk of anxiety, depressive and their co-morbidity symptoms in middle school students, and the directionality of the association should be further studied.
- Vitamin D deficiency /
- Anxiety /
- Depression /
- Mental health /
- Regression analysis /
- Students
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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表 1 不同人口统计学特征中学生焦虑、抑郁及焦虑抑郁共病症状检出率比较

Table 1. Comparison of the detection rates of anxiety, depression and anxiety-depression co-morbid symptoms among middle school students with different demographic characteristics

人口统计学指标	选项	人数	焦虑症状		抑郁症状		焦虑抑郁共病症状
人口统计学指标	选项	人数	检出人数	χ²值	检出人数	χ²值	检出人数	χ²值
性别	男	776	210(27.1)	30.23^**	149(19.2)	6.09^*	106(13.7)	9.77^**
	女	547	227(41.5)		136(24.9)		110(20.1)
年级	初一	431	108(25.1)	18.37^**	81(18.8)	2.86	62(14.4)	1.76
	高一	892	329(36.9)		204(22.9)		154(17.3)
BMI	正常	916	309(33.7)	1.50	203(22.2)	3.88	154(16.8)	1.46
	消瘦	79	27(34.2)		13(16.5)		12(15.2)
	超重	198	58(29.3)		36(18.2)		27(13.6)
	肥胖	130	43(33.1)		33(25.4)		23(17.7)
独生子女	否	1 071	367(34.3)	3.88^*	234(21.8)	0.31	177(16.5)	0.17
	是	252	70(27.8)		51(20.2)		39(15.5)
父亲文化程度	初中及以下	468	155(33.1)	0.29	105(22.4)	2.53	80(17.1)	1.21
	高中或中专	471	159(33.8)		108(22.9)		80(17.0)
	大专及以上	384	123(32.0)		72(18.8)		56(14.6)
母亲文化程度	初中及以下	611	190(31.1)	3.74	129(21.1)	1.21	94(15.4)	3.15
	高中或中专	417	153(36.7)		97(23.3)		79(18.9)
	大专及以上	295	94(31.9)		59(20.0)		43(14.6)
吸烟	否	1 306	429(32.8)	1.53	279(21.4)	1.93	212(16.2)	0.65
	是	17	8(47.1)		6(35.3)		4(23.5)
饮酒	否	1 195	373(31.2)	18.45^**	235(19.7)	25.74^**	176(14.7)	23.10^**
	是	128	64(50.0)		50(39.1)		40(31.3)
家庭经济情况	差或较差	155	62(40.0)	5.05	42(27.1)	5.98	29(18.7)	1.85
	中等	915	301(32.9)		200(21.9)		152(16.6)
	好或较好	253	74(29.2)		43(17.0)		35(13.8)
朋友数量/个	≤2	381	171(44.9)	34.25^**	117(30.7)	27.56^**	90(23.6)	21.59^**
	3~5	532	154(28.9)		101(19.0)		76(14.3)
	≥6	410	112(27.3)		67(16.3)		50(12.2)
学习负担	重或很重	529	240(45.4)	62.09^**	151(28.5)	26.54^**	126(23.8)	36.96^**
	一般	728	185(25.4)		126(17.3)		85(11.7)
	轻或较轻	66	12(18.2)		8(12.1)		5(7.6)
维生素D水平	充足	855	260(30.4)	11.67^**	163(19.1)	11.85^**	124(14.5)	8.60^*
	不足	359	127(35.4)		87(24.2)		65(18.1)
	缺乏	109	50(45.9)		35(32.1)		27(24.8)
注： ()内数字为检出率/%；P＜0.05，*P＜0.01。

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表 2 中学生维生素D水平与焦虑、抑郁及焦虑抑郁共病症状的多因素Logistic分析(n=1 323)

Table 2. Multivariate Logistic regression analysis of vitamin D levels and anxiety, depression and co-morbid symptoms of middle school students(n=1 323)

维生素D水平	焦虑症状^a		抑郁症状^b		焦虑抑郁共病症状^b
维生素D水平	OR值(95%CI)	P值	OR值(95%CI)	P值	OR值(95%CI)	P值
不足	1.13(0.85~1.50)	0.40	1.35(0.99~1.84)	0.06	1.25(0.88~1.77)	0.21
缺乏	1.59(1.02~2.46)	0.04	1.94(1.22~3.09)	＜0.01	1.75(1.06~2.90)	0.03
注： a控制性别、年级、是否独生子女、饮酒情况、朋友数量、学习负担；b控制性别、饮酒情况、朋友数量、学习负担。

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