儿童青春期发育时相评价方法研究进展

汪姗姗; 孙莹; 陶芳标

doi:10.16835/j.cnki.1000-9817.2023.06.035

儿童青春期发育时相评价方法研究进展

doi: 10.16835/j.cnki.1000-9817.2023.06.035

安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室，合肥 230032

基金项目:

国家自然科学基金项目 82173537

国家自然科学基金项目 81872638

安徽省自然科学基金杰青项目 1908085J26

详细信息

作者简介:
汪姗姗(1994-)，女，安徽安庆人，在读博士，主要研究方向为儿童青少年卫生

通讯作者:
孙莹，E-mail：yingsun@ahmu.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R193
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出版历程
- 收稿日期: 2023-02-08
- 网络出版日期: 2023-06-28
- 刊出日期: 2023-06-25

Advances in evaluation methods of pubertal timing in children

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Ministry of Education Key Laboratory of Population Health Across Life Cycle, Hefei(230032), China

摘要

摘要: 近40年来，中国儿童青春期发育时相呈现逐渐提前的长期趋势。青春期发育提前与儿童心理健康和行为问题密切相关，可能导致成年后心血管代谢疾病、内分泌系统癌症、骨关节系统异常等。青春期发育提前儿童的早期发现十分重要，当前评价青春期发育时相的方法有多种，其适用性值得探讨。研究通过对既往文献进行综述，梳理当前青春期发育时相评价方法的研究进展，评估其在中国儿童青少年人群研究中的适用性，为中国儿童青春期发育时相评价方法的选择提供参考。
- 青春期发育 /
- 评价方法 /
- 研究 /
- 儿童
Abstract: Over the past 40 years, there has been a long-term trend of early pubertal onset in children in China. Early pubertal timing is closely associated with mental health and behavioral problems in children, and can even lead to cardiovascular and metabolic diseases, cancers of the endocrine system and abnormalities of the bone and joint system in adulthood. Prompt detection of early pubertal timing in children is important. There are many methods for evaluating pubertal timing, the appropriateness of which is worth exploring. This paper reviews previous literature publications, examines current research progress in evaluation methods of pubertal timing, evaluates their applicability in the study of children and adolescents, and provides a reference for the selection of an evaluation method to assess pubertal timing in children in China.
- Adolescent development /
- Assessment method /
- Research /
- Child
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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表 1 中国汉族男女童青春期发育提前年龄参考值/岁

Table 1. Reference age of early puberty for Chinese Han boys and girls/year

性别	青春期指标	P₃(95%CI)	P₁₀(95%CI)	P₂₅(95%CI)	P₅₀(95%CI)	P₇₅(95%CI)	P₉₀(95%CI)	P₉₇(95%CI)
女	乳房发育TannerⅡ期	5.86(5.17~6.39)	6.92(6.39~7.33)	7.99(7.60~8.31)	9.18(8.91~9.44)	10.32(10.10~10.67)	11.44(11.10~11.87)	12.50(12.06~13.07)
	乳房发育TannerⅢ期	7.32(6.75~7.80)	8.57(8.13~8.94)	9.82(9.50~10.11)	11.22(10.97~11.46)	12.62(12.35~12.92)	13.87(13.53~14.28)	15.11(14.67~15.65)
	阴毛发育TannerⅡ期	8.64(8.09~9.08)	9.60(9.18~9.95)	10.57(10.26~10.84)	10.57(10.26~10.84)	12.73(12.47~13.04)	13.71(13.37~14.12)	14.67(14.24~15.21)
	阴毛发育TannerⅢ期	8.98(8.28~9.53)	10.30(9.77~10.72)	11.64(11.25~11.97)	13.12(12.82~13.42)	14.61(14.28~15.00)	15.95(15.52~16.48)	17.27(16.71~17.97)
	月经初潮	9.74(8.58~10.45)	10.60(9.72~10.17)	11.47(10.83~11.93)	12.43(11.97~12.88)	13.40(12.95~13.99)	14.27(13.72~15.09)	15.13(14.45~16.22)
男	外生殖器发育TannerⅡ期	7.60(7.25~7.90)	8.76(8.49~9.00)	9.94(9.74~10.12)	9.94(9.74~10.12)	12.55(12.36~12.66)	13.73(13.48~14.01)	14.89(14.58~15.26)
	外生殖器发育TannerⅢ期	9.73(9.46~9.97)	10.81(10.60~11.00)	11.90(11.74~12.04)	13.11(12.97~13.24)	14.32(14.16~14.48)	14.32(14.16~14.48)	16.48(16.22~16.77)
	阴毛发育TannerⅡ期	9.46(9.02~9.83)	10.48(10.14~10.77)	11.52(11.27~11.75)	12.67(12.46~12.88)	13.82(13.58~14.09)	14.86(14.55~15.22)	15.88(15.49~16.34)
	阴毛发育TannerⅢ期	10.18(9.74~10.55)	11.27(10.93~11.55)	12.36(12.11~12.59)	13.58(13.37~13.80)	14.80(14.56~15.08)	15.90(15.59~16.27)	16.98(16.59~17.46)
	睾丸容积≥4 mL	7.25(6.89~7.57)	7.25(6.89~7.57)	9.67(9.46~9.86)	11.02(10.85~11.19)	12.37(12.17~12.58)	13.58(13.33~13.87)	14.78(14.46~14.87)
	首次遗精	11.05(10.55~11.45)	12.09(11.72~12.40)	13.15(12.88~13.39)	14.32(14.10~14.55)	15.49(15.23~15.81)	16.55(16.23~16.98)	17.59(17.14~18.15)

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