孤独症谱系障碍儿童感觉特征与脑灰质体积的相关性

朱婷; 王龙龙; 王亚蓉; 王磊; 乔乐天; 张欣悦; 刘展会; 乔向阳; 王艳萍; 杨淑涵

doi:10.16835/j.cnki.1000-9817.2023.04.024

孤独症谱系障碍儿童感觉特征与脑灰质体积的相关性

doi: 10.16835/j.cnki.1000-9817.2023.04.024

1.
陕西省西安市第九医院, 710054
2.
西安交通大学第一附属医院医学影像科
3.
西安市大兴医院影像科
4.
西安医学院临床医学
5.
齐齐哈尔医学院医学技术学院医学影像系

基金项目:

国家自然科学基金项目 81803265

陕西省卫生健康科研基金项目 2018D003

详细信息

作者简介:
朱婷(1993-)，女，山西省人，硕士，住院医师，主要从事儿童发育行为相关工作

通讯作者:
杨淑涵，E-mail：yangshuhanchina@163.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R748 R179 B844.1
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- PDF下载量: 16
- 被引次数: 0
出版历程
- 收稿日期: 2023-01-28
- 修回日期: 2023-03-07
- 网络出版日期: 2023-04-26
- 刊出日期: 2023-04-25

Relationship between sensory characteristics and gray matter volumes in children with autism spectrum disorders

1.
Xi'an Ninth Hospital, Xi'an(710054), China

摘要

摘要: 目的探讨孤独症谱系障碍(ASD)儿童感觉特征与脑灰质体积的潜在关联，为ASD儿童的诊断和治疗提供依据。方法选取在西安市ASD诊疗机构就诊或康复的40名ASD和在西安市多所幼儿园公开招募的16名正常发育(TD)儿童，采用感觉讯息处理及自我调节功能检查表评估感觉特征，采用3D TIWI采集脑结构图像，利用基于体素的形态学测量方法分析脑灰质体积。将感觉特征和脑灰质体积进行组间比较，并分析感觉特征与脑灰质体积的相关性。结果 ASD组的听觉、视觉、触觉、感觉讯息处理功能及对感觉刺激的反应-不足得分均低于TD组(Z/t值分别为-2.63，-2.57，-3.11，-2.19，-3.83，P值均 < 0.05)。ASD组有左侧小脑后下叶、右侧小脑后下叶、右海马旁回、左岛叶、左额内侧回、左枕上回、右枕上回、右上顶叶及右中央后回脑灰质体积较TD组增大(t值分别为3.53，3.69，3.37，3.86，3.61，3.37，4.04，3.38，3.16，P值均＜0.01)。ASD组视觉、前庭平衡觉、本体感觉、感觉讯息处理功能、对感觉刺激的寻求及对感觉刺激的反应-过度强烈得分与左枕上回灰质体积均呈负相关(r值分别为-0.36，-0.40，-0.39，-0.36，-0.40，-0.36)，视觉、前庭平衡觉及对感觉刺激的反应-过度强烈得分与右上顶叶灰质体积均呈负相关(r值分别为-0.36，-0.50，-0.42)(P值均＜0.05)。结论 ASD儿童存在感觉异常，且与左枕上回和右上顶叶灰质体积有关。
- 孤独性障碍 /
- 大脑皮质 /
- 精神卫生 /
- 儿童，学龄前
Abstract: Objective To investigate the potential relationship between sensory characteristics and gray matter volumes in children with autism spectrum disorders (ASD), to provide a basis for the diagnosis and treatment of children with ASD. Methods A total of 40 ASD children who were treated or recovered in Xi'an medical institutions and 16 typically developing (TD) children who were from several kindergatens in Xi'an were invited for participation. Sensory characteristics were evaluated by the sensory processing and self-regulation checklist, 3D structural brain images were obtained with TIWI, and gray matter volumes were analyzed by voxel-based morphometry. Sensory characteristics and gray matter volumes were compared between groups and the relationship between sensory characteristics and different gray matter volumes were analyzed. Results The scores of auditory, visual, tactile, sensory processing ability and sensory under-responsivity in the ASD group were lower than those in the TD group (Z/t=-2.63, -2.57, -3.11, -2.19, -3.83, P < 0.05). Gray matter volumes in nine brain regions increased in the ASD group compared to the TD group, including the left and right posterior inferior lobe, right parahippocamal gyrus, left insula, left media frontal gyrus, left superion occipital gyrus, right superion occipital gyrus, right superion parietal lobe, and right posterion central gyrus (t=3.53, 3.69, 3.37, 3.86, 3.61, 3.37, 4.04, 3.38, 3.16, P < 0.01). In the ASD group, the scores of visual, vestibular, proprioceptive, sensory processing ability, sensory-seeking behavior and sensory over-responsivity were negatively correlated with gray matter volumes of left superior occipital gyrus (r=-0.36, -0.40, -0.39, -0.36, -0.40, -0.36), and the scores of visual, vestibular, and sensory over-responsivity were negatively correlated with gray matter volumes of the right superior parietal lobule (r=-0.36, -0.50, -0.42)(P < 0.05). Conclusion The presence of paresthesia in children with ASD is associated with gray matter volumes of the left superior occipital gyrus and right superior parietal lobule.
- Autistic disorder /
- Cerebral cortex /
- Mental health /
- Child, preschool
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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表 1 ASD组与TD组儿童感觉讯息处理功能得分比较(x±s)

Table 1. Comparison of scores of sensory processing ability between ASD and TD groups(x±s)

组别	人数	听觉^*	视觉	触觉^*	味觉及嗅觉^*	前庭平衡感觉	本体感觉	感觉讯息处理功能	对感觉刺激的寻求	对感觉刺激的反应-不足^*	对感觉刺激的反应-过度强烈	对感觉刺激的反应-稳定性^*
ASD组	40	64(55，69)	54.57±6.06	79(71，89)	57(53，62)	74.00±8.57	59.00±7.92	385.97±39.81	140.86±17.39	101(89，109)	123.54±13.68	23(19，28)
TD组	16	74(61，75)	60.07±8.31	93(83，95)	62(54，65)	78.14±12.97	60.21±9.35	415.00±47.19	150.29±19.62	114(110，115)	128.07±22.17	27(23，30)
Z/t值		-2.63	-2.57	-3.11	-1.30	-1.10	-0.46	-2.19	-1.65	-3.83	-0.87	-1.70
P值		< 0.01	< 0.05	< 0.01	0.19	0.29	0.65	< 0.05	0.11	< 0.01	0.39	0.09
注： ^*为M(P₂₅，P₇₅)。

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