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炎症和免疫与儿童孤独症谱系障碍研究的CiteSpace分析

崔庭凯 车亦凡 张欣

崔庭凯, 车亦凡, 张欣. 炎症和免疫与儿童孤独症谱系障碍研究的CiteSpace分析[J]. 中国学校卫生, 2022, 43(12): 1843-1846. doi: 10.16835/j.cnki.1000-9817.2022.12.020
引用本文: 崔庭凯, 车亦凡, 张欣. 炎症和免疫与儿童孤独症谱系障碍研究的CiteSpace分析[J]. 中国学校卫生, 2022, 43(12): 1843-1846. doi: 10.16835/j.cnki.1000-9817.2022.12.020
CUI Tingkai, CHE Yifan, ZHANG Xin. Association between inflammation and immunity with child autism spectrum disorder based on CiteSpace analysis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(12): 1843-1846. doi: 10.16835/j.cnki.1000-9817.2022.12.020
Citation: CUI Tingkai, CHE Yifan, ZHANG Xin. Association between inflammation and immunity with child autism spectrum disorder based on CiteSpace analysis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(12): 1843-1846. doi: 10.16835/j.cnki.1000-9817.2022.12.020

炎症和免疫与儿童孤独症谱系障碍研究的CiteSpace分析

doi: 10.16835/j.cnki.1000-9817.2022.12.020
基金项目: 

天津市应用基础研究多元投入基金项目-生命健康项目 21JCQNJC01720

国家自然科学基金面上项目 81973070

详细信息
    作者简介:

    崔庭凯(1990-),男,天津市人,博士,讲师,主要研究方向为儿童神经心理发育

    通讯作者:

    张欣,E-mail:zhangxin@tmu.edu.cn

  • 利益冲突声明  所有作者声明无利益冲突。
  • 中图分类号: R179 R748

Association between inflammation and immunity with child autism spectrum disorder based on CiteSpace analysis

  • 摘要:   目的  对2002—2021年孤独症谱系障碍(autism spectrum disorder, ASD)炎症与免疫方面研究进行文献计量分析,为炎症与免疫因素在儿童ASD发病机制中研究提供参考。  方法  2022年5月以Web of Science数据库核心合集为文献来源,使用CiteSpace软件进行分析,最终纳入文献4 458篇。  结果  2002—2021年发文量迅速增加,由52篇增加至528篇。美国发文量最高,为2 016篇;中国次之,为407篇。高频词依次为autism spectrum disorder,children,brain,autism,spectrum disorder等,高中心性关键词依次为schizophrenia,central nervous system,mental retardation,multiple sclerosis,autoantibody等。研究趋势与热点分析表明,研究内容主要集中在核心症状及脑机制研究、基因与环境交互作用研究、流行病学研究3个方面,而母体免疫激活与肠脑轴逐渐成为研究热点。  结论  ASD炎症与免疫研究在近20年发展较为迅速,近期研究热点主要集中在母体免疫激活与肠脑轴等致病机制方面。中国应加大相关研究力度,为儿童ASD预防、干预和治疗提供科学依据。
    1)  利益冲突声明  所有作者声明无利益冲突。
  • 图  1  ASD炎症与免疫相关研究2002—2021年发文量

    Figure  1.  Number of articles published in the field of inflammation and immunity of ASD from 2002 to 2021

    表  1  ASD炎症与免疫相关研究发文量及中心性前10位国家

    Table  1.   The top 10 countries of the count of publications in the field of inflammation and immunity of ASD

    名次 国家 首次发文年份 发文量 中心性
    1 美国 2002 2 016 0.48
    2 中国 2002 407 0.09
    3 意大利 2002 359 0.17
    4 英国 2002 301 0.12
    5 日本 2002 248 0.13
    6 加拿大 2003 242 0.16
    7 德国 2002 182 0.22
    8 法国 2002 157 0.12
    9 澳大利亚 2003 144 0.04
    10 沙特阿拉伯 2006 132 0.01
    下载: 导出CSV

    表  2  ASD炎症与免疫相关研究发文量及中心性前10家机构

    Table  2.   The top 10 institutions of the count of publications in the field of inflammation and immunity of ASD

    名次 机构名称 国家 发文量 中心性
    1 University of California, Davis 美国 222 0.10
    2 Harvard University 美国 156 0.12
    3 King Saud University 沙特阿拉伯 107 0.02
    4 Johns Hopkins University 美国 92 0.08
    5 Columbia University 美国 67 0.04
    6 University of California, Los Angeles 美国 63 0.09
    7 University of Toronto 加拿大 58 0.03
    8 Tufts University 美国 54 0.02
    9 University of California, San Diego 美国 47 0.02
    10 King's College London 英国 46 0.02
    下载: 导出CSV

    表  3  ASD免疫与炎症相关研究高频和高中心性关键词

    Table  3.   High frequency and high centrality keywords in the field of inflammation and immunity of ASD

    名次 高频次 高中心性
    关键词 频次 关键词 中心性
    1 autism spectrum disorder 948 schizophrenia 0.24
    2 children 887 central nervous system 0.21
    3 brain 547 mental retardation 0.21
    4 autism 526 multiple sclerosis 0.20
    5 spectrum disorder 470 autoantibody 0.20
    6 expression 385 antibrain antibody 0.20
    7 oxidative stress 301 measles virus 0.16
    8 inflammation 292 nitric oxide 0.16
    9 activation 284 measle 0.15
    10 association 272 brain 0.14
    下载: 导出CSV

    表  4  ASD炎症与免疫相关研究关键词突现情况

    Table  4.   Keywords burst in the field of inflammation and immunity of ASD

    关键词 突现强度 起始年份 结束年份
    pervasive 29.23 2002 2012
    mump 23.75 2002 2010
    measle 23.61 2002 2012
    immunization 19.97 2002 2012
    t cell 19.97 2002 2013
    inflammatory bowel disease 19.92 2002 2011
    autoantibody 19.66 2002 2014
    infantile autism 17.05 2002 2011
    rubella vaccine 16.39 2002 2007
    antibody 24.29 2003 2014
    population 14.65 2003 2011
    developmental disorder 13.25 2003 2009
    fetal brain 15.72 2009 2014
    necrosis factor alpha 15.42 2010 2014
    bipolar disorder 12.26 2013 2017
    prefrontal cortex 14.88 2014 2017
    gut microbiota 19.35 2018 2021
    neuroinflammation 13.33 2018 2019
    cytokine 13.38 2019 2021
    microglia 12.92 2019 2021
    下载: 导出CSV

    表  5  ASD炎症与免疫研究共被引文献突现情况

    Table  5.   Co-citation of literature in the field of inflammation and immunity of ASD

    序号 第一作者与年份 突现强度 起始年份 结束年份
    1 Vargas(2005)[4] 54.05 2005 2010
    2 Ashwood(2006)[5] 37.02 2008 2011
    3 Smith(2007)[6] 33.40 2009 2012
    4 Li(2009)[7] 42.64 2010 2014
    5 Atladóttir(2010)[8] 44.11 2011 2015
    6 Ashwood(2011)[9] 41.42 2011 2016
    7 Hallmayer(2011)[10] 42.50 2012 2016
    8 Voineagu(2011)[11] 32.07 2012 2016
    9 Onore(2012)[12] 47.20 2013 2017
    10 Malkovan(2012)[13] 38.67 2013 2017
    11 Hsiao(2013)[14] 51.41 2015 2018
    12 American Psychiatric Association(2013)[1] 41.13 2015 2018
    13 Knuesel(2014)[15] 34.09 2016 2019
    14 Estes(2015)[16] 33.60 2016 2021
    15 Choi(2016)[17] 53.93 2017 2021
    16 Estes(2016)[18] 55.79 2018 2021
    17 Kang(2017)[19] 40.51 2018 2021
    18 Meltzer(2017)[20] 39.75 2018 2021
    19 Kim(2017)[21] 34.82 2018 2021
    20 Baio(2018)[22] 48.08 2019 2021
    下载: 导出CSV
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出版历程
  • 收稿日期:  2022-09-01
  • 修回日期:  2022-10-11
  • 网络出版日期:  2022-12-30
  • 刊出日期:  2022-12-25

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