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盐诱导激酶3基因单核苷酸多态性rs12225230与儿童肥胖表型的关联

李雪莹 李晨雄 宋洁云 王辉 王海俊

李雪莹, 李晨雄, 宋洁云, 王辉, 王海俊. 盐诱导激酶3基因单核苷酸多态性rs12225230与儿童肥胖表型的关联[J]. 中国学校卫生, 2022, 43(11): 1634-1637. doi: 10.16835/j.cnki.1000-9817.2022.11.009
引用本文: 李雪莹, 李晨雄, 宋洁云, 王辉, 王海俊. 盐诱导激酶3基因单核苷酸多态性rs12225230与儿童肥胖表型的关联[J]. 中国学校卫生, 2022, 43(11): 1634-1637. doi: 10.16835/j.cnki.1000-9817.2022.11.009
LI Xueying, LI Chenxiong, SONG Jieyun, WANG Hui, WANG Haijun. Association between SIK3 SNP rs12225230 with obese phenotype in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(11): 1634-1637. doi: 10.16835/j.cnki.1000-9817.2022.11.009
Citation: LI Xueying, LI Chenxiong, SONG Jieyun, WANG Hui, WANG Haijun. Association between SIK3 SNP rs12225230 with obese phenotype in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(11): 1634-1637. doi: 10.16835/j.cnki.1000-9817.2022.11.009

盐诱导激酶3基因单核苷酸多态性rs12225230与儿童肥胖表型的关联

doi: 10.16835/j.cnki.1000-9817.2022.11.009
详细信息
    作者简介:

    李雪莹(1997-), 女, 云南昆明人, 在读硕士, 主要研究方向为儿童非酒精性脂肪性肝病的遗传易感性

    通讯作者:

    王辉, E-mail: huiwang@bjmu.edu.cn

  • 利益冲突声明  所有作者声明无利益冲突。
  • 中图分类号: R 723.14 R 446 R 179

Association between SIK3 SNP rs12225230 with obese phenotype in children

  • 摘要:   目的  探讨盐诱导激酶3(SIK3)基因单核苷酸多态性rs12225230与儿童青少年肥胖相关表型的关联,为儿童青少年肥胖的筛查干预提供证据。  方法  整群抽取北京市2 030名7~18岁儿童青少年为研究对象,进行身体测量及超重肥胖分组。利用基质辅助激光解析/电离飞行时间质谱(MALDI-TOF MS)检测单核苷酸多态性rs12225230基因型频率。分别采用Logistic回归和多元线性回归分析单核苷酸多态性rs12225230与肥胖、中心性肥胖相关表型的关联。使用Polyphen2数据库分析单核苷酸多态性rs12225230对SIK3基因蛋白质功能的影响;使用GTEx数据库探索与单核苷酸多态性rs12225230相关联的组织特异性基因表达。  结果  单核苷酸多态性rs12225230 C等位基因是儿童青少年肥胖、重度肥胖发生的危险因素(OR肥胖=1.50,95%CI=1.10~2.04,P=0.01;OR重度肥胖=1.72,95%CI=1.23~2.39,P < 0.01)。单核苷酸多态性rs12225230 C等位基因与腰围、腰高比存在正相关(β腰围=1.40,95%CI=0.28~2.52,P=0.01;β腰高比=0.01,95%CI=0.00~0.02,P=0.01);单核苷酸多态性rs12225230 C等位基因对SIK3基因编码的蛋白质可能存在功能损害,且与心脏组织中APOA1基因表达升高相关。  结论  SIK3基因单核苷酸多态性rs12225230与儿童青少年肥胖、中心性肥胖相关,且与APOA1表达相关,但与脂代谢之间的关联尚需进一步论证。
    1)  利益冲突声明  所有作者声明无利益冲突。
  • 表  1  不同组别7~18岁儿童青少年基本情况比较(x±s)

    Table  1.   Comparison of characteristics of children and adolescents aged 7-18 in different groups(x±s)

    组别 人数 年龄/岁 身高/cm BMI/(kg·m-2) 腰围/cm 腰高比
    体重正常组 607 12.55±3.04 156.20±15.86 18.78±2.50 64.71±7.72 0.41±0.03
    超重组 718 13.25±2.37 161.96±13.01 23.85±2.21 77.80±7.22 0.48±0.03
    肥胖组 705 12.85±2.59 162.78±13.79 28.11±3.94 88.12±11.28 0.54±0.05
    重度肥胖组 475 13.31±2.36 164.47±12.48 29.58±3.63 91.23±10.64 0.55±0.05
    F 11.34 38.68 1 406.22 965.78 1 637.08
    P <0.01 <0.01 <0.01 <0.01 <0.01
    下载: 导出CSV
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出版历程
  • 收稿日期:  2022-02-22
  • 修回日期:  2022-03-08
  • 网络出版日期:  2022-11-30
  • 刊出日期:  2022-11-25

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