睡眠及昼夜节律与儿童青少年近视发生的关联

李丹琳; 刘民歆; 梁刚; 潘臣炜

doi:10.16835/j.cnki.1000-9817.2022.09.036

睡眠及昼夜节律与儿童青少年近视发生的关联

doi: 10.16835/j.cnki.1000-9817.2022.09.036

1.
苏州大学苏州医学院公共卫生学院，江苏 215123
2.
云南大学附属医院眼科

基金项目:

国家重点研发计划资助 2021YFC2702100

国家重点研发计划资助 2021YFC2702

详细信息

作者简介:
李丹琳(1994-)，女，四川绵阳人，在读博士，主要研究方向为儿童青少年近视防控

通讯作者:
潘臣炜，E-mail：pcwonly@gmail.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R122 R179 R725.6
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- 文章访问数: 574
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- 被引次数: 0
出版历程
- 收稿日期: 2021-12-07
- 修回日期: 2022-02-02
- 网络出版日期: 2022-09-23
- 刊出日期: 2022-09-25

Association between sleep and circadian rhythms with the development of myopia in children and adolescents

1.
School of Public Health, Suzhou Medical College of Soochow University, Suzhou (215123), Jiangsu Province, China

摘要

摘要: 儿童青少年近视率逐年上升，且呈低龄化趋势，影响了儿童青少年身心健康。睡眠问题在儿童青少年中也普遍存在，如睡眠时间减少、入睡时间延迟等。睡眠是一种周期性的生命活动，受昼夜节律的影响，此外，近视也与睡眠和昼夜节律密切相关。研究通过回顾与总结相关文献，从人群流行病学、动物模型研究综述了睡眠、昼夜节律与儿童青少年近视发生的关联，并探讨其中的生物学机制，为儿童青少年近视防控提供科学依据。
- 睡眠 /
- 昼夜节律 /
- 近视 /
- 儿童 /
- 青少年
Abstract: The incidence of myopia in children and adolescents has increased in recent years, with an earlier onset trend. During the same time, sleep problems are prevalent in children and adolescents, including insufficient sleep duration and delayed sleep timing. Sleep, as a cyclical life activity influenced by the circadian rhythm, plays an important role in eye growth and refractive development. This review examines the associations between sleep, circadian rhythm, and occurrence of myopia in children and adolescents across human and animal studies, and discusses the underlying biological processes, so as to offer scientific justification for the prevention of myopia in children and adolescents.
- Sleep /
- Circadian rhythm /
- Myopia /
- Child /
- Adolescent
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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参考文献(60)

[1]	KLEIN D L, MOORE R Y, REPPERT S M. Suprachiasmatic Nucleus: the mind's clock[M]. New York: Oxford University Press, 1991.
[2]	ZEE P C, ABBOTT S M. Circadian rhythm sleep-wake disorders[J]. Continuum(Minneap Minn), 2020, 26(4): 988-1002.
[3]	ALBRECHT U. Timing to perfection: the biology of central and peripheral circadian clocks[J]. Neuron, 2012, 74(2): 246-260. doi: 10.1016/j.neuron.2012.04.006
[4]	LEGATES T A, FERNANDEZ D C, HATTAR S. Light as a central modulator of circadian rhythms, sleep and affect[J]. Nat Rev Neurosci, 2014, 15(7): 443-454.
[5]	ZELINSKI E L, DEIBEL S H, MCDONALD R J. The trouble with circadian clock dysfunction: multiple deleterious effects on the brain and body[J]. Neurosci Biobehav Rev, 2014, 40: 80-101. doi: 10.1016/j.neubiorev.2014.01.007
[6]	SPILLMANN L. Stopping the rise of myopia in Asia[J]. Graefes Arch Clin Exp Ophthalmol, 2020, 258(5): 943-959. doi: 10.1007/s00417-019-04555-0
[7]	PAN C W, WU R K, WANG P, et al. Reduced vision, refractive errors and health-related quality of life among adolescents in rural China[J]. Clin Exp Optom, 2018, 101(6): 758-763. doi: 10.1111/cxo.12680
[8]	JEE D, MORGAN I G, KIM E C. Inverse relationship between sleep duration and myopia[J]. Acta Ophthalmol, 2016, 94(3): e204-e210. doi: 10.1111/aos.12776
[9]	王悦, 郑康杰, 谢辉, 等. 宝山区青少年不同近视程度对睡眠质量的影响[J]. 中国学校卫生, 2021, 42(2): 190-194. doi: 10.16835/j.cnki.1000-9817.2021.02.008 WANG Y, ZHENG K J, XIE H, et al. Impact of different myopia degree on sleep quality among adolescents in Baoshan District[J]. Chin J Sch health, 2021, 42(2): 190-194. doi: 10.16835/j.cnki.1000-9817.2021.02.008
[10]	QUINN G E, SHIN C H, MAGUIRE M G, et al. Myopia and ambient lighting at night[J]. Nature, 1999, 399(6732): 113-114. doi: 10.1038/20094
[11]	SAW S M, WU H M, HONG C Y, et al. Myopia and night lighting in children in Singapore[J]. Br J Ophthalmol, 2001, 85(5): 527-528. doi: 10.1136/bjo.85.5.527
[12]	GUGGENHEIM J A, HILL C, YAM T F. Myopia, genetics, and ambient lighting at night in a UK sample[J]. Br J Ophthalmol, 2003, 87(5): 580-582. doi: 10.1136/bjo.87.5.580
[13]	林林, 满丰韬, 胡乃宝, 等. 青少年近视的危险因素研究[J]. 中国儿童保健杂志, 2013, 21(2): 206-209. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201302040.htm LIN L, MAN F T, HU N B, et al. Study of relationship between sleep quality, obesity and juvenile myopia[J]. Chin J Child Health Care, 2013, 21(2): 206-209. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201302040.htm
[14]	GONG Y, ZHANG X, TIAN P, et al. Parental myopia, near work, hours of sleep and myopia in Chinese children[J]. Health, 2014, 6(1): 64-70. doi: 10.4236/health.2014.61010
[15]	JEE D, MORGAN I G, KIM E C. Inverse relationship between sleep duration and myopia[J]. Acta ophthalmol, 2016, 94(3): e204-e210. doi: 10.1111/aos.12776
[16]	许韶君, 万宇辉, 徐增辉, 等. 体育锻炼、睡眠和家庭作业时间与中小学生疑似近视的关系[J]. 中华流行病学杂志, 2016, 37(2): 183-186. doi: 10.3760/cma.j.issn.0254-6450.2016.02.006 XU S J, WAN Y H, XU Z H, et al. Association between time spent on physical exercise, sleep, homework and suspected myopia among students[J]. Chin J Epidemiol, 2016, 37(2): 183-186. doi: 10.3760/cma.j.issn.0254-6450.2016.02.006
[17]	PAN C W, LIU J H, WU R K, et al. Disordered sleep and myopia among adolescents: a propensity score matching analysis[J]. Ophthalmic Epidemiol, 2019, 26(3): 155-160. doi: 10.1080/09286586.2018.1554159
[18]	KEARNEY S, O'DONOGHUE L, POURSHAHIDI L K, et al. Myopes have significantly higher serum melatonin concentrations than non-myopes[J]. Ophthalmic Physiol Opt, 2017, 37(5): 557-567. doi: 10.1111/opo.12396
[19]	KUMAR S, GUPTA N, VELPANDIAN T, et al. Myopia, melatonin and conjunctival ultraviolet autofluorescence: a comparative cross-sectional study in Indian myopes[J]. Curr Eye Res, 2021, 46(10): 1474-1481. doi: 10.1080/02713683.2021.1894580
[20]	JENSEN L S, MATSON W E. Enlargement of avian eye by subjecting chicks to continuous incandescent illumination[J]. Science, 1957, 125(3251): 741. doi: 10.1126/science.125.3251.741.b
[21]	LAUBER J K, SHUTZE J M J. Effects of exposure to continuous light on the eye of the growing chick[J]. Proc Soc Exp Biol Med, 1961, 106: 871-872. doi: 10.3181/00379727-106-26505
[22]	LAUBER J K, MCGINNIS J. Eye lesions in domestic fowl reared under continuous light[J]. Vision Res, 1966, 6(12): 619-626.
[23]	GOTTLIEB M D, FUGATE-WENTZEK L A, WALLMAN J. Different visual deprivations produce different ametropias and different eye shapes[J]. Invest Ophthalmol Vis Sci, 1987, 28(8): 1225-1235.
[24]	STONE R A, LIN T, DESAI D, et al. Photoperiod, early post-natal eye growth, and visual deprivation[J]. Vision Res, 1995, 35(9): 1195-1202. doi: 10.1016/0042-6989(94)00232-B
[25]	LI T, WAHL C, HOWLAND H C. Age dependent ocular changes of chicks under constant light, and recovery from them, in normal illumination[J]. Invest Ophthalmol Vis Sci, 2004, 452: U416.
[26]	ZHOU X, AN J, WU X, et al. Relative axial myopia induced by prolonged light exposure in C57BL/6 mice[J]. Photochem Photobiol, 2010, 86(1): 131-137. doi: 10.1111/j.1751-1097.2009.00637.x
[27]	SMITH E R, BRADLEY D V, FERNANDES A, et al. Continuous ambient lighting and eye growth in primates[J]. Invest Ophthalmol Vis Sci, 2001, 42(6): 1146-1152.
[28]	SMITH E R, HUNG L F, KEE C S, et al. Continuous ambient lighting and lens compensation in infant monkeys[J]. Optom Vis Sci, 2003, 80(5): 374-382. doi: 10.1097/00006324-200305000-00012
[29]	STONE R A, MCGLINN A M, CHAKRABORTY R, et al. Altered ocular parameters from circadian clock gene disruptions[J]. PLoS One, 2019, 14(6): e217111.
[30]	吴涛, 倪银华, 夏李群, 等. 视网膜生物钟研究进展[J]. 现代生物医学进展, 2007, 7(8): 1249-1250. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX200708053.htm WU T, NI Y H, XIA L Q, et al. Research progress on the biochronometer in the retina[J]. Prog Mod Biomed, 2007, 7(8): 1249-1250. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX200708053.htm
[31]	CHAKRABORTY R, OSTRIN L A, NICKLA D L, et al. Circadian rhythms, refractive development, and myopia[J]. Ophthalmic Physiol Optics, 2018, 38(3): 217-245. doi: 10.1111/opo.12453
[32]	WEISS S, SCHAEFFEL F. Diurnal growth rhythms in the chicken eye: relation to myopia development and retinal dopamine levels[J]. J Comp Physiol A, 1993, 172(3): 263-270. doi: 10.1007/BF00216608
[33]	NICKLA D L, WILDSOET C, WALLMAN J. Visual influences on diurnal rhythms in ocular length and choroidal thickness in chick eyes[J]. Exp Eye Res, 1998, 66(2): 163-181. doi: 10.1006/exer.1997.0420
[34]	PAPASTERGIOU G I, SCHMID G F, RIVA C E, et al. Ocular axial length and choroidal thickness in newly hatched chicks and one-year-old chickens fluctuate in a diurnal pattern that is influenced by visual experience and intraocular pressure changes[J]. Exp Eye Res, 1998, 66(2): 195-205. doi: 10.1006/exer.1997.0421
[35]	NICKLA D L, WILDSOET C F, TROILO D. Diurnal rhythms in intraocular pressure, axial length, and choroidal thickness in a primate model of eye growth, the common marmoset[J]. Invest Ophthalmol Vis Sci, 2002, 43(8): 2519-2528.
[36]	WILSON L B, QUINN G E, YING G S, et al. The relation of axial length and intraocular pressure fluctuations in human eyes[J]. Invest Ophthalmol Vis Sci, 2006, 47(5): 1778-1784. doi: 10.1167/iovs.05-0869
[37]	CHAKRABORTY R, READ S A, COLLINS M J. Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics[J]. Invest Ophthalmol Vis Sci, 2011, 52(8): 5121-5129. doi: 10.1167/iovs.11-7364
[38]	DO M T, YAU K W. Intrinsically photosensitive retinal ganglion cells[J]. Physiol Rev, 2010, 90(4): 1547-1581. doi: 10.1152/physrev.00013.2010
[39]	BESHARSE J C, IUVONE P M. Circadian clock in Xenopus eye controlling retinal serotonin N-acetyltransferase[J]. Nature, 1983, 305(5930): 133-135. doi: 10.1038/305133a0
[40]	CAHILL G M, BESHARSE J C. Circadian clock functions localized in xenopus retinal photoreceptors[J]. Neuron, 1993, 10(4): 573-577. doi: 10.1016/0896-6273(93)90160-S
[41]	MCMAHON D G, IUVONE P M, TOSINI G. Circadian organization of the mammalian retina: from gene regulation to physiology and diseases[J]. Prog Retin Eye Res, 2014, 39: 58-76. doi: 10.1016/j.preteyeres.2013.12.001
[42]	RUAN G X, GAMBLE K L, RISNER M L, et al. Divergent roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators[J]. PLoS One, 2012, 7(6): e38985. doi: 10.1371/journal.pone.0038985
[43]	ZHOU X, PARDUE M T, IUVONE P M, et al. Dopamine signaling and myopia development: what are the key challenges[J]. Prog Retin Eye Res, 2017, 61: 60-71. doi: 10.1016/j.preteyeres.2017.06.003
[44]	KORSHUNOV K S, BLAKEMORE L J, TROMBLEY P Q. Dopamine: a modulator of circadian rhythms in the central nervous system[J]. Front Cell Neurosci, 2017, 11: 91.
[45]	HWANG C K, CHAURASIA S S, JACKSON C R, et al. Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells[J]. J Neurosci, 2013, 33(38): 14989-14997. doi: 10.1523/JNEUROSCI.2039-13.2013
[46]	KUNST S, WOLLOSCHECK T, KELLEHER D K, et al. Pgc-1alpha and Nr4a1 are target genes of circadian melatonin and dopamine release in murine retina[J]. Invest Ophthalmol Vis Sci, 2015, 56(10): 6084-6094. doi: 10.1167/iovs.15-17503
[47]	MUNTEANU T, NORONHA K J, LEUNG A C, et al. Light-dependent pathways for dopaminergic amacrine cell development and function[J]. Elife, 2018, 7: e3986.
[48]	RUAN G X, ALLEN G C, YAMAZAKI S, et al. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA[J]. PLoS Biol, 2008, 6(10): e249. doi: 10.1371/journal.pbio.0060249
[49]	JACKSON C R, CHAURASIA S S, HWANG C K, et al. Dopamine D(4) receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina[J]. Eur J Neurosci, 2011, 34(1): 57-64. doi: 10.1111/j.1460-9568.2011.07734.x
[50]	ZHANG Z, LI H, LIU X, et al. Circadian clock control of connexin 36 phosphorylation in retinal photoreceptors of the CBA/CaJ mouse strain[J]. Vis Neurosci, 2015, 32: E9.
[51]	YOSHIKAWA M, YAMASHIRO K, MIYAKE M, et al. Comprehensive replication of the relationshipbetween myopia-related genes and refractive errors in a large Japanese cohort[J]. Invest Ophthalmol Vis Sci, 2014, 55(11): 7343-7354. doi: 10.1167/iovs.14-15105
[52]	FELDKAEMPER M, SCHAEFFEL F. An updated view on the role of dopamine in myopia[J]. Exp Eye Res, 2013, 114: 106-119. doi: 10.1016/j.exer.2013.02.007
[53]	CHAKRABORTY R, LEE D C, LANDIS E G, et al. Melanopsin knock-out mice have refractive development and increased susceptibility to form-deprivation myopia[J]. Invest Ophthalmol Vis Sci, 2015, 56(7): 5843.
[54]	OSTERGAARD J, HANNIBAL J, FAHRENKRUG J. Synaptic contact between melanopsin-containing retinal ganglion cells and rod bipolar cells[J]. Invest Ophthalmol Vis Sci, 2007, 48(8): 3812-3820. doi: 10.1167/iovs.06-1322
[55]	PRIGGE C L, YEH P T, LIOU N F, et al. M1 ipRGCs influence visual function through retrograde signaling in the retina[J]. J Neurosci, 2016, 36(27): 7184-7197. doi: 10.1523/JNEUROSCI.3500-15.2016
[56]	SAKAMOTO K, LIU C, KASAMATSU M, et al. Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells[J]. Eur J Neurosci, 2005, 22(12): 3129-3136. doi: 10.1111/j.1460-9568.2005.04512.x
[57]	BRAINARD G C, HANIFIN J P, GREESON J M, et al. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor[J]. J Neurosci, 2001, 21(16): 6405-6412. doi: 10.1523/JNEUROSCI.21-16-06405.2001
[58]	WANG F, ZHOU J, LU Y, et al. Effects of 530 nm green light on refractive status, melatonin, MT1 receptor, and melanopsin in the guinea pig[J]. Curr Eye Res, 2011, 36(2): 103-111. doi: 10.3109/02713683.2010.526750
[59]	KEARNEY S, O'DONOGHUE L, POURSHAHIDI L K, et al. Myopes have significantly higher serum melatonin concentrations than non-myopes[J]. Ophthalmic Physiol Opt, 2017, 37(5): 557-567. doi: 10.1111/opo.12396
[60]	STONE R A, PARDUE M T, IUVONE P M, et al. Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms[J]. Exp Eye Res, 2013, 114: 35-47. doi: 10.1016/j.exer.2013.01.001