低能量红光在儿童青少年近视弱视中的应用

章歆梓; 黄建南; 许迅; 何鲜桂

doi:10.16835/j.cnki.1000-9817.2022.07.036

低能量红光在儿童青少年近视弱视中的应用

doi: 10.16835/j.cnki.1000-9817.2022.07.036

上海市眼病防治中心/上海市眼科医院/上海市视觉健康中心(儿童青少年近视防治技术中心)/上海交通大学第一人民医院/国家眼部疾病临床医学研究中心/上海市眼底病重点实验室/上海眼视觉与光医学工程技术研究中心，上海 201103

基金项目:

国家重点研发计划资助 2021YFC2702100

国家重点研发计划资助 2021YFC2702104

国家重点研发计划资助 2019YFC0840607

上海市“科技创新行动计划”医学创新研究专项项目 21Y11910000

上海市加强公共卫生体系建设优秀学科带头人培养计划 GWV-10.2-XD09

详细信息

作者简介:
章歆梓(1999-)，女，浙江诸暨人，大学本科，主要研究方向为近视眼科学

通讯作者:
何鲜桂，E-mail：xianhezi@163.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R778 R779.7
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- 被引次数: 0
出版历程
- 收稿日期: 2022-03-25
- 修回日期: 2022-04-15
- 网络出版日期: 2022-07-27
- 刊出日期: 2022-07-25

Application of low-level red light in myopia and amblyopia in children and adolescents

Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital/Shanghai Vision Health Center and Shanghai Children Myopia Institute/Shanghai General Hospital Affiliated with Shanghai Jiao Tong University/National Clinical Research Center for Eye Diseases/Shanghai Key Laboratory of Ocular Fundus Diseases/Shanghai Engineering Center for Visual Science and Photomedicine(201103), Shanghai, China

摘要

摘要: 近视与弱视是威胁儿童青少年眼健康的重要疾病，红光用于弱视治疗已有几十年历史，近年来逐渐应用于儿童青少年近视防控，成为新热点。通过从低能量红光治疗的干预方式、治疗效果、影响因素、可能机制及安全性方面阐述其在儿童青少年近视弱视中的应用，以期为下一步研究与实践提供参考。
- 近视 /
- 弱视 /
- 光疗法 /
- 儿童 /
- 青少年
Abstract: Low-level light therapy utilizes the photochemical effect of red light to induce reactions in the irradiated body tissue to achieve the therapeutic effect. Myopia and amblyopia are diseases which threaten the eye health of children and adolescents. Red light has been used to treat amblyopia for decades. Recently, its application in myopia prevention and control has become a new hotspot. This review summarizes the application of low-level red light in children and adolescents with myopia and amblyopia from the aspects of intervention mode, effect, factors, mechanism and safety to provide reference for future researches.
- Myopia /
- Amblyopia /
- Phototherapy /
- Child /
- Adolescent
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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表 1 红光控制近视相关研究的光源参数及照射方案

Table 1. Light source parameters and irradiation regimens of red light controlling myopia

第一作者	试验方法	年龄/岁	样本量	红光波长/nm	输出功率/mW	光标直径/mm	照射方案
Jiang^[15]	多中心随机对照试验	8~13	264	650±10	2.0±0.5	未描述	2次/d，3 min/次；5 d/周
陈培正^[16]	回顾性观察对照	3~15	120	650±10	2.0±0.5	10±3	2次/d，3 min/次；7 d/周
闫艺^[17]	随机对照试验	7~12	120	650±10	2.0±0.5	10±3	2次/d，3 min/次；7 d/周
Xiong^[18]	随机对照试验	6~16	300	650±5	2.0±0.5	5	2次/d，3 min/次；7 d/周
Zhou^[19]	回顾性观察对照	3~14	161	635±2	0.4	未描述	2次/d，3 min/次；7 d/周

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表 2 氦氖激光照射治疗弱视的研究设计、光源参数及照射方案

Table 2. Study design, light source parameters and irradiation regimens of He-Ne laser treating amblyopia

第一作者	眼数	干预组	对照组	功率/mW	光源距离	照射时间	照射方案
林再雄^[33]	340	氦氖激光+弱视综合治疗仪	弱视综合治疗仪	0.8	10 cm	3 min/d	20 d/疗程，若6月后未愈可行第2疗程
陆莉^[34]	127	氦氖激光+综合弱视协调仪	未设置	0.8	未描述	3 min/d	连续20 d
杨蕴华^[35]	787	氦氖激光+视觉生理刺激仪+海丁格光刷	未设置	0.3	未描述	3 min/d	连续20 d
杨小梅^[36]	146	氦氖激光+视觉生理刺激仪+海丁格光刷	未设置	0.8~1.0	5~10 cm	3 min/d	20 d/疗程, 若未愈继续行综合治疗仪治疗
王爽^[37]	884	氦氖激光+传统综合治疗	传统综合治疗	0.3	35 cm	3 min/d	连续20 d
潘冰心^[38]	56	氦氖激光+后像法+弱视治疗仪	未设置	0.9~1.0	未描述	3 min/d	21 d/疗程，6月后根据情况重复疗程，期间行弱视治疗仪巩固治疗

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