大学生高尿酸血症相关因素分析

郭丽; 张秀花; 朱旻

doi:10.16835/j.cnki.1000-9817.2022.07.029

大学生高尿酸血症相关因素分析

doi: 10.16835/j.cnki.1000-9817.2022.07.029

苏州大学医院预防保健科，江苏 215006

详细信息

作者简介:
郭丽(1977-)，女，重庆万州人，硕士，主治医师，主要从事健康教育与健康促进工作

通讯作者:
朱旻，E-mail：zhu@suda.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R446 G647.8 R725.7
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- 被引次数: 0
出版历程
- 收稿日期: 2022-01-29
- 修回日期: 2022-04-02
- 网络出版日期: 2022-07-27
- 刊出日期: 2022-07-25

Analysis of factors associated with hyperuricemia in college students

Department of Disease Prevention and Health Care, Soochow University Hospital, Suzhou(215006), Jiangsu Province, China

摘要

摘要: 目的了解大学生人群高尿酸血症的检出情况及相关因素，为大学生高尿酸血症的防治提供依据。方法选取苏州大学2021年参加入学体检的11 858名学生体检数据，比较不同特征组高尿酸血症的检出率，并采用多因素Logistic回归探讨大学生高尿酸血症的影响因素。结果高尿酸血症检出3 372例，检出率为28.4%。男生检出率(42.4%)高于女生(14.6%)，检出率随体质量指数(BMI)值升高而上升，高血压患者及本科生中检出率高于其他组(χ²值分别为1 126.2，180.7，138.2，107.9，P值均 < 0.01)。多因素Logistic回归分析发现，男性、低龄、高BMI、高血压和高血红蛋白水平均与大学生高尿酸血症的发生呈正相关，而高肾小球滤过率与高尿酸血症的发生呈负相关(P值均 < 0.01)。结论针对高尿酸血症的高检出率，应加强对大学生尤其是本科生、男生、超重肥胖者、高血压患者及高血红蛋白水平者进行有针对性的健康宣教。
- 高尿酸血症 /
- 人体质量指数 /
- 血压 /
- 回归分析 /
- 学生
Abstract: Objective To understand the prevalence of hyperuricemia in university students and examine associated factors, and to provide evidence for the prevention and treatment of hyperuricemia. Methods Health examination data of 11 858 students for admission in October 2021 were used to compare the detection rates between groups with different characteristics. Multivariable Logistic regression was performed to identify potential factors associated with hyperuricemia. Results A total of 3 372 cases of hyperuricemia were found, with a detection rate of 28.4%. The detection rate of male students was significantly higher than that of female students (42.4%, 14.6%). The rate increased with higher BMI. Moreover, the detection rate was higher among undergraduates and those with hypertension(χ²=1 126.2, 180.7, 138.2, 107.9, P < 0.01). Multivariable Logistic regression analysis showed that male sex, younger age, higher BMI, hypertension and higher hemoglobin level were positively associated with hyperuricemia, whereas higher glomerular filtration rate was negatively associated among the students(P < 0.01). Conclusion Greater attention should be given to hyperuricemia in university students, and targeted health education should be strengthened for them, especially undergraduates, boys, overweight and obese students, and those with hypertension or high hemoglobin levels.
- Hyperuricemia /
- Body mass index /
- Blood pressure /
- Regression analysis /
- Students
注释:

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表 1 不同人口学特征大学生人群高尿酸血症检出率比较

Table 1. Comparison of the detection rate of hyperuricemia among university students with different characteristics

特征	人数	高尿酸血症检出人数	χ²值	P值
性别
女	5 951	868(14.6)	1 126.2	< 0.01
男	5 907	2 504(42.4)
年龄/岁
< 19	3 583	1 196(33.4)	103.0	< 0.01
19~22	3 831	1 139(29.7)
≥23	4 444	1 037(23.3)
BMI/(kg·m^-2)
< 18.5	18	2(11.1)	180.7	< 0.01
18.5~23.9	11 567	3 194(27.6)
≥24	273	176(64.5)
高血压
否	11 544	3 190(27.6)	138.2	< 0.01
是	314	182(58.0)
学生类别
本科生	5 318	1 766(33.2)	107.9	< 0.01
研究生	6 540	1 606(24.6)
注： ()内数字为检出率/%。

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表 2 大学生高尿酸血症多因素Logistic回归分析(n=11 858)

Table 2. Multivariable Logistic regression analysis of hyperuricemia among university students(n=11 858)

自变量	选项	Wald χ²值	OR值(OR值95%CI)	P值
性别	女		1.00
	男	168.1	2.54(2.21~2.93)	< 0.01
年龄/岁	< 19		1.00
	19~22	22.8	0.77(0.69~0.86)	< 0.01
	≥23	197.4	0.44(0.39~0.49)	< 0.01
BMI	< 18.5	3.5	0.21(0.04~1.08)	0.06
/(kg·m^-2)	18.5~23.9		1.00
	≥24	45.1	2.95(2.15~4.04)	< 0.01
高血压	否		1.00
	是	4.4	1.37(1.02~1.83)	0.04
eGFR/[mL·(min·1.73 m²)^-1]		244.6	0.96(0.96~0.97)	< 0.01
血红蛋白/(g·L^-1)		23.2	4.67(2.50~8.76)	< 0.01

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