内蒙古儿童青少年高三酰甘油腰围表型与高尿酸血症的关系

曹宁; 李乐慧; 张楠; 牛丽薇; 吕海明; 张星光

doi:10.16835/j.cnki.1000-9817.2022.07.027

内蒙古儿童青少年高三酰甘油腰围表型与高尿酸血症的关系

doi: 10.16835/j.cnki.1000-9817.2022.07.027

曹宁¹,
李乐慧¹,
张楠¹,
牛丽薇¹,
吕海明^2, ,,
张星光^1, ,

1.
内蒙古医科大学公共卫生学院，呼和浩特 010110
2.
赤峰市克什克腾旗中医蒙医医院

基金项目:

内蒙古自治区自然科学基金项目 2020MS08048

内蒙古自治区高等学校科学研究项目 NJZY22617

详细信息

作者简介:
曹宁(1989-)，女，内蒙古呼和浩特人，硕士，讲师，主要研究方向为慢性病流行病学

通讯作者:
吕海明，E-mail：lhming65@126.com

张星光，E-mail：zxg311@126.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R446 R181.3 R589.7
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- 被引次数: 0
出版历程
- 收稿日期: 2022-03-10
- 修回日期: 2022-04-11
- 网络出版日期: 2022-07-27
- 刊出日期: 2022-07-25

Association between hyperuricemia and hypertriglyceridemic-waist phenotype in children and adolescents in Inner Mongolia

1.
School of Public Health, Inner Mongolia Medical University, Hohhot(010110), China

摘要

摘要: 目的研究内蒙古6~17岁儿童青少年高尿酸血症(hyperuricemia, HUA)的患病情况和高三酰甘油腰围(hypotriglyceridemic-waist, HTW) 表型的检出情况，并探讨两者的关系，为内蒙古儿童青少年高尿酸血症的防治提供依据。方法采用多阶段分层随机抽样的方法选择内蒙古8个旗县(区)的小学、初中和高中2 175名学生进行问卷调查、体格检查和实验室检测。采用二元Logistic回归分析HTW表型和HUA的相关性。结果研究对象HTW表型检出率为2.1%，男生检出率(2.5%)高于女生(1.6%)(χ²=14.50，P < 0.05)。血尿酸(serum uric acid, SUA)平均水平为308.00(259.00，371.00)mmol/L，性别间差异有统计学意义(Z=-9.87，P < 0.05)，HUA患病率为21.1%。HTW表型的HUA患病率(44.4%)高于其他表型，其次为高腰围(enlarged waist, EW)表型(36.2%)。校正其他因素后，EW表型(OR=1.76，95%CI=1.26~2.47)和HTW表型(OR=2.25，95%CI=1.12~4.52)与HUA发病均呈正相关(P值均 < 0.05)。结论内蒙古6~17岁儿童青少年的HUA患病率较高，HTW表型与高尿酸血症呈正相关。在高尿酸血症的预防中，应加强对具有HTW表型儿童青少年的关注。
- 高尿酸血症 /
- 患病率 /
- 回归分析 /
- 儿童 /
- 青少年
Abstract: Objective To investigate the prevalence and association of hyperuricemia (HUA) and hypertriglyceridemic-Waist (HTW) phenotype in children and adolescents aged 6-17 years in Inner Mongolia, providing a basis for the prevention and treatment of hyperuricemia in adolescents in Inner Mongolia. Methods A total of 2 175 students of primary, junior high, and senior high school students from eight counties (districts) in Inner Mongolia were chosen and received a questionnaire survey, physical examination, and laboratory test by used a multi-stage stratified random sampling approach. The association between the HTW phenotype and HUA was analyzed using binary Logistic regression. Results The prevalence of the HTW phenotype was 2.1%, with boys(2.5%) higher than that of girls(1.6%) (χ²=14.50, P < 0.05). The average SUA level of the participants was 308.00 (259.00, 371.00) mmol/L, with a statistically significant sex difference(Z=-9.87, P < 0.05). The prevalence of HUA was 21.1%. The frequency of HUA in the HTW phenotype(44.4%) was higher than in other phenotypes, followed by enlarged waist (EW) phenotype. After controlling for associated variables, the EW phenotypes (OR=1.76, 95%CI=1.26-2.47) and HTW phenotypes (OR=2.25, 95%CI=1.12-4.52) were associated with higher risk for HUA(P < 0.05). Conclusion In Inner Mongolia, the prevalence of HUA in children and adolescents aged 6-17 years is high, and there shows a positive association between the HTW phenotype and hyperuricemia. For the prevention of hyperuricemia, more attention should be paid to children and adolescents with HTW phenotype.
- Hyperuricemia /
- Prevalence /
- Regression analysis /
- Child /
- Adolescent
注释:

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表 1 不同年龄、性别儿童青少年各表型检出率比较

Table 1. Comparison of the prevalence of various phenotypes in children and adolescents of different ages and genders

组别	选项	人数	NTNW	HTG	EW	HTW
年龄/岁	6~9	757	613(81.0)	21(2.8)	110(14.5)	13(1.7)
	10~14	982	747(76.1)	34(3.5)	177(18.0)	24(2.4)
	15~17	436	329(75.5)	8(1.8)	91(20.9)	8(1.8)
性别	男	1 080	836(77.4)	44(4.1)	173(16.0)	27(2.5)
	女	1 095	853(77.9)	19(1.7)	205(17.0)	18(1.6)
注： ()内数字为检出率/%。

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表 2 不同性别各年龄段儿童青少年血尿酸水平比较[M(P₂₅, P₇₅), mmol/L]

Table 2. Comparison of blood uric acid levels in children and adolescents of different genders and ages[M(P₂₅, P₇₅), mmol/L]

性别	人数	6岁	7岁	8岁	9岁	10岁	11岁
男	1 080	285.00(240.25, 317.50)	275.00(240.00, 312.00)	282.00(241.00, 330.25)	282.00(243.00, 336.50)	284.00(240.00, 338.00)	322.00(270.50, 370.00)
女	1 095	268.50(227.25, 314.50)	280.00(238.00, 315.00)	267.50(228.75, 312.00)	276.50(233.00, 328.50)	283.00(240.00, 330.00)	302.00(267.00, 359.00)
合计	2 175	274.00(237.00, 314.25)	277.50(238.75, 314.00)	277.00(238.50, 324.00)	279.00(242.00, 331.00)	284.00(240.25, 336.00)	308.00(269.50, 368.00)
Z值		-1.16	-0.55	-1.68	-0.86	-0.36	-0.87
P值		0.25	0.58	0.09	0.39	0.72	0.39

性别	人数	12岁	13岁	14岁	15岁	16岁	17岁
男	1 080	360.00(287.75, 428.25)	398.50(343.00, 441.75)	419.00(350.00, 481.25)	410.00(353.75, 450.50)	410.00(357.00, 475.50)	368.00(325.25, 434.00)
女	1 095	330.00(280.00, 389.00)	312.00(276.75, 352.25)	310.00(263.25, 343.25)	310.00(250.00, 373.00)	299.50(263.00, 341.00)	286.50(236.50, 331.00)
合计	2 175	339.00(284.00, 406.00)	351.00(300.25, 409.00)	348.50(294.00, 423.75)	363.00(295.00, 417.00)	343.00(291.00, 416.00)	334.00(270.25, 414.25)
Z值		-2.40	-7.06	-6.07	-5.40	-8.72	-5.04
P值		0.02	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01

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