生命早期脂肪高峰与脂肪重积聚的流行病学研究进展

林丹; 史慧静

doi:10.16835/j.cnki.1000-9817.2022.06.035

生命早期脂肪高峰与脂肪重积聚的流行病学研究进展

doi: 10.16835/j.cnki.1000-9817.2022.06.035

林丹,
史慧静^,

复旦大学公共卫生学院妇幼与儿少卫生教研室, 上海 200032

基金项目:

上海市加强公共卫生体系建设第五轮重点学科建设项目 GWV-10.1-XK08

详细信息

作者简介:
林丹(1983-)，女，福建福州人，在读博士，副编审，主要研究方向为生命早期保健和慢性病预防

通讯作者:
史慧静，E-mail：hjshi@fudan.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R181.3 R179
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- 文章访问数: 443
- HTML全文浏览量: 212
- PDF下载量: 37
- 被引次数: 0
出版历程
- 收稿日期: 2021-12-14
- 修回日期: 2022-01-20
- 网络出版日期: 2022-06-23
- 刊出日期: 2022-06-25

Epidemiological research progress of adiposity peak and adiposity rebound in early life

LIN Dan,
SHI Huijing^,

Department of Maternal, Child and Adolescent Health, School of Public Health, Fudan University, Shanghai (200032), China

摘要

摘要: 脂肪高峰(adiposity peak, AP)与脂肪重积聚(adiposity rebound, AR)是生命早期身体质量指数(body mass index, BMI)生长轨迹的最高点和最低点, 也是其最明显的特征。流行病学研究报道了世界各地不同人群AP和AR出现时间和出现时的BMI值。另有研究观察了产前、产后、喂养、经济社会等因素对其出现时间和出现时BMI值的影响。更有时间跨度较大的纵向研究追踪了对其出现时间和出现时BMI值对生命后期许多负性健康结局的影响。该综述基于大量文献, 总结了AP和AR的出现时间与出现时的BMI值在全球范围内的流行病学特征, 生命前期与生命早期决定因素, 及其可能长生的长期健康效应, 为肥胖及相关慢性疾病的预防与干预工作提供科学依据, 并总结了针对该研究问题目前尚存在的争议, 为今后研究指明方向。
- 生命周期各时期 /
- 脂肪组织 /
- 流行病学研究 /
- 人体质量指数
Abstract: The adiposity peak (AP) and adiposity rebound (AR) are the highest and lowest points of the body mass index (BMI) growth trajectory in early life. They are also the most significant characteristics. Epidemiological studies have reported the timings and BMI magnitudes of AP and AR in different populations worldwide. Others have observed the impacts of prenatal, postpartum, feeding, economic and social factors on the timing and magnitude of them. In addition, longitudinal studies have tracked the health effect of the timing and magnitude of them on many adverse health outcomes in later life. Based on literature reviews, we summarize the global epidemiological characteristics of AP and AR, while identifying pre-and early-life determinants as well as their possible long-term health effects, so as to provide scientific evidence for the prevention and management of obesity and related chronic diseases. We also highlight current controversies regarding this issue, while outlining directions for future research.
- Life cycle stages /
- Adipose tissue /
- Epidemiologic studies /
- Body mass index
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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参考文献(62)

[1]	BRANNSETHER B, EIDE G E, ROELANTS M, et al. BMI and BMI SDS in childhood: annual increments and conditional change[J]. Ann Hum Biol, 2017, 44(1): 28-33. doi: 10.3109/03014460.2016.1151933
[2]	WEN X, KLEINMAN K, GILLMAN M W, et al. Childhood body mass index trajectories: modeling, characterizing, pairwise correlations and socio-demographic predictors of trajectory characteristics[J]. BMC Med Res Methodol, 2012, 12: 38. doi: 10.1186/1471-2288-12-38
[3]	ROY S M, CHESI A, MENTCH F, et al. Body mass index (BMI) trajectories in infancy differ by population ancestry and may presage disparities in early childhood obesity[J]. J Clin Endocrinol Metab, 2015, 100(4): 1551-1560. doi: 10.1210/jc.2014-4028
[4]	GUZZARDI M A, IOZZO P, SALONEN M K, et al. Maternal adiposity and infancy growth predict later telomere length: a longitudinal cohort study[J]. Int J Obes(Lond), 2016, 40(7): 1063-1069. doi: 10.1038/ijo.2016.58
[5]	OTO Y, MURAKAMI N, MATSUBARA K, et al. Early adiposity rebound in patients with prader-willi syndrome[J]. J Pediatr Endocrinol Metab, 2018, 31(12): 1311-1314. doi: 10.1515/jpem-2018-0301
[6]	MIN J, WEN X, XUE H, et al. Ethnic disparities in childhood BMI trajectories and obesity and potential causes among 29, 250 US children: findings from the early childhood longitudinal study-birth and kindergarten cohorts[J]. Int J Obes(Lond), 2018, 42(9): 1661-1670. doi: 10.1038/s41366-018-0091-4
[7]	WARRINGTON N M, WU Y Y, PENNELL C E, et al. Modelling BMI trajectories in children for genetic association studies[J]. PLoS One, 2013, 8(1): e53897. doi: 10.1371/journal.pone.0053897
[8]	NEDELEC R, MIETTUNEN J, MANNIKKO M, et al. Maternal and infant prediction of the child BMI trajectories; studies across two generations of northern finland birth cohorts[J]. Int J Obes(Lond), 2021, 45(2): 404-414. doi: 10.1038/s41366-020-00695-0
[9]	JOHNSON W, CHOH A C, LEE M, et al. Characterization of the infant BMI peak: sex differences, birth year cohort effects, association with concurrent adiposity, and heritability[J]. Am J Hum Biol, 2013, 25(3): 378-388. doi: 10.1002/ajhb.22385
[10]	ARIS I M, RIFAS-SHIMAN S L, LI L J, et al. Pre-, perinatal, and parental predictors of body mass index trajectory milestones[J]. J Pediatr, 2018, 201: 69-77. doi: 10.1016/j.jpeds.2018.05.041
[11]	WEN X Z, CHEN Z H, WEI Y Z, et al. Evolution of viral RNA in a Chinese patient to interferon/ribavirin therapy for hepatitis C[J]. Chin J Cancer Res, 2012, 24(4): 353-360. doi: 10.1007/s11670-012-0275-8
[12]	BEYERLEIN A, THIERING E, PFLUEGER M, et al. Early infant growth is associated with the risk of islet autoimmunity in genetically susceptible children[J]. Pediatr Diabetes, 2014, 15(7): 534-542. doi: 10.1111/pedi.12118
[13]	FLEXEDER C, THIERING E, KRATZSCH J, et al. Is a child's growth pattern early in life related to serum adipokines at the age of 10 years?[J]. Eur J Clin Nutr, 2014, 68(1): 25-31. doi: 10.1038/ejcn.2013.213
[14]	KROKE A, HAHN S, BUYKEN A E, et al. A comparative evaluation of two different approaches to estimating age at adiposity rebound[J]. Int J Obes(Lond), 2006, 30(2): 261-266. doi: 10.1038/sj.ijo.0803143
[15]	VRIJKOTTE T G M, OOSTVOGELS A, STRONKS K, et al. Growth patterns from birth to overweight at age 5-6 years of children with various backgrounds in socioeconomic status and country of origin: the ABCD study[J]. Pediatr Obes, 2020, 15(8): e12635.
[16]	CASAS M, DEN DEKKER H T, KRUITHOF C J, et al. The effect of early growth patterns and lung function on the development of childhood asthma: a population based study[J]. Thorax, 2018, 73(12): 1137-1145. doi: 10.1136/thoraxjnl-2017-211216
[17]	PEDERSEN L, LAURITZEN L, BRASHOLT M, et al. Polyunsaturated fatty acid content of mother's milk is associated with childhood body composition[J]. Pediatr Res, 2012, 72(6): 631-636. doi: 10.1038/pr.2012.127
[18]	JENSEN S M, RITZ C, EJLERSKOV K T, et al. Infant BMI peak, breastfeeding, and body composition at age 3 y[J]. Am J Clin Nutr, 2015, 101(2): 319-325. doi: 10.3945/ajcn.114.092957
[19]	OHLSSON C, LORENTZON M, NORJAVAARA E, et al. Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study[J]. PLoS One, 2012, 7(11): e49404. doi: 10.1371/journal.pone.0049404
[20]	CHIVERS P, HANDS B, PARKER H, et al. Longitudinal modelling of body mass index from birth to 14 years[J]. Obes Facts, 2009, 2(5): 302-310. doi: 10.1159/000235561
[21]	BORNHORST C, SIANI A, TORNARITIS M, et al. Potential selection effects when estimating associations between the infancy peak or adiposity rebound and later body mass index in children[J]. Int J Obes (Lond), 2017, 41(4): 518-526. doi: 10.1038/ijo.2016.218
[22]	PERNG W, RAHMAN M L, ARIS I M, et al. Metabolite profiles of the relationship between Body Mass Index (BMI) milestones and metabolic risk during early adolescence[J]. Metabolites, 2020, 10(8): 316. doi: 10.3390/metabo10080316
[23]	BELSKY D W, MOFFITT T E, HOUTS R, et al. Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study[J]. Arch Pediatr Adolesc Med, 2012, 166(6): 515-521.
[24]	WHITAKER R C, PEPE M S, WRIGHT J A, et al. Early adiposity rebound and the risk of adult obesity[J]. Pediatrics, 1998, 101(3): E5. doi: 10.1542/peds.101.3.e5
[25]	OURA P, PAANANEN M, OJANIEMI M, et al. Effect of early life physical growth on midlife vertebral dimensions-the northern finland birth cohort 1966 study[J]. Bone, 2017, 101: 172-178. doi: 10.1016/j.bone.2017.05.006
[26]	PERNG W, BAEK J, ZHOU C W, et al. Associations of the infancy body mass index peak with anthropometry and cardiometabolic risk in Mexican adolescents[J]. Ann Hum Biol, 2018, 45(5): 386-394. doi: 10.1080/03014460.2018.1506048
[27]	CHEN L W, ARIS I M, BERNARD J Y, et al. Associations of maternal macronutrient intake during pregnancy with infant BMI peak characteristics and childhood BMI[J]. Am J Clin Nutr, 2017, 105(3): 705-713. doi: 10.3945/ajcn.116.148270
[28]	NOUHJAH S, SHAHBAZIAN H, LATIFI S M, et al. Body mass index growth trajectories from birth through 24 months in Iranian infants of mothers with gestational diabetes mellitus[J]. Diabetes Metab Syndr, 2019, 13(1): 408-412. doi: 10.1016/j.dsx.2018.10.002
[29]	HOF M H, VRIJKOTTE T G, DE HOOG M L, et al. Association between infancy BMI peak and body composition and blood pressure at age 5-6 years[J]. PLoS One, 2013, 8(12): e80517. doi: 10.1371/journal.pone.0080517
[30]	WONG S C, NG S M, DIDI M. Children with congenital hypothyroidism are at risk of adult obesity due to early adiposity rebound[J]. Clin Endocrinol (Oxf), 2004, 61(4): 441-446. doi: 10.1111/j.1365-2265.2004.02116.x
[31]	SILVERWOOD R J, DE STAVOLA B L, COLE T J, et al. BMI peak in infancy as a predictor for later BMI in the uppsala family study[J]. Int J Obes(Lond), 2009, 33(8): 929-937. doi: 10.1038/ijo.2009.108
[32]	BHARGAVA S K, SACHDEV H S, FALL C H, et al. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood[J]. N Engl J Med, 2004, 350(9): 865-875. doi: 10.1056/NEJMoa035698
[33]	ESTEVEZ-GONZALEZ M D, SANTANA DEL PINO A, HENRIQUEZ-SANCHEZ P, et al. Breastfeeding during the first 6 months of life, adiposity rebound and overweight/obesity at 8 years of age[J]. Int J Obes(Lond), 2016, 40(1): 10-13. doi: 10.1038/ijo.2015.228
[34]	WILLIAMS S M. Weight and height growth rate and the timing of adiposity rebound[J]. Obes Res, 2005, 13(6): 1123-1130. doi: 10.1038/oby.2005.131
[35]	ELLISON J A, PATEL L, KECOJEVIC T, et al. Pattern of growth and adiposity from infancy to adulthood in atopic dermatitis[J]. Br J Dermatol, 2006, 155(3): 532-538. doi: 10.1111/j.1365-2133.2006.07400.x
[36]	SHI H Q, ZHOU X T, XU X W, et al. Tunable phonon blockade in quadratically coupled optomechanical systems[J]. Sci Rep, 2018, 8(1): 2212. doi: 10.1038/s41598-018-20568-x
[37]	GUO S S, HUANG C, MAYNARD L M, et al. Body mass index during childhood, adolescence and young adulthood in relation to adult overweight and adiposity: the Fels Longitudinal Study[J]. Int J Obes Relat Metab Disord, 2000, 24(12): 1628-1635. doi: 10.1038/sj.ijo.0801461
[38]	WU Y, LYE S, DENNIS C L, et al. Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort[J]. PLoS Genet, 2020, 16(6): e1008790. doi: 10.1371/journal.pgen.1008790
[39]	WU Y Y, LYE S, BRIOLLAIS L. The role of early life growth development, the FTO gene and exclusive breastfeeding on child BMI trajectories[J]. Int J Epidemiol, 2017, 46(5): 1512-1522. doi: 10.1093/ije/dyx081
[40]	JOHNSON W, SOLOWAY L E, ERICKSON D, et al. A changing pattern of childhood BMI growth during the 20th century: 70 y of data from the Fels Longitudinal Study[J]. Am J Clin Nutr, 2012, 95(5): 1136-1143. doi: 10.3945/ajcn.111.022269
[41]	IP E H, MARSHALL S A, SALDANA S, et al. Determinants of adiposity rebound timing in children[J]. J Pediatr, 2017, 184: 151-156. doi: 10.1016/j.jpeds.2017.01.051
[42]	DOROSTY A R, EMMETT P M, COWIN S, et al. Factors associated with early adiposity rebound. ALSPAC Study Team[J]. Pediatrics, 2000, 105(5): 1115-1118. doi: 10.1542/peds.105.5.1115
[43]	SOVIO U, MOOK-KANAMORI D O, WARRINGTON N M, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development[J]. PLoS Genet, 2011, 7(2): e1001307. doi: 10.1371/journal.pgen.1001307
[44]	CASAS M, DEN DEKKER H T, KRUITHOF C J, et al. Early childhood growth patterns and school-age respiratory resistance, fractional exhaled nitric oxide and asthma[J]. Pediatr Allergy Immunol, 2016, 27(8): 854-860. doi: 10.1111/pai.12645
[45]	SUN J, NWARU B I, HUA J, et al. Infant BMI peak as a predictor of overweight and obesity at age 2 years in a Chinese community-based cohort[J]. BMJ Open, 2017, 7(10): e015122. doi: 10.1136/bmjopen-2016-015122
[46]	SOVIO U, KAAKINEN M, TZOULAKI I, et al. How do changes in body mass index in infancy and childhood associate with cardiometabolic profile in adulthood?Findings from the Northern Finland Birth Cohort 1966 Study[J]. Int J Obes(Lond), 2014, 38(1): 53-59. doi: 10.1038/ijo.2013.165
[47]	MARINKOVIC T, TOEMEN L, KRUITHOF C J, et al. Early infant growth velocity patterns and cardiovascular and metabolic outcomes in childhood[J]. J Pediatr, 2017, 186: 57-63. doi: 10.1016/j.jpeds.2017.02.004
[48]	MONNEREAU C, VOGELEZANG S, KRUITHOF C J, et al. Associations of genetic risk scores based on adult adiposity pathways with childhood growth and adiposity measures[J]. BMC Genet, 2016, 17(1): 120. doi: 10.1186/s12863-016-0425-y
[49]	KORPELA N, KAIKKONEN K, AUVINEN J, et al. Early growth patterns and cardiac structure and function at midlife: Northern Finland 1966 Birth Cohort Study[J]. J Pediatr, 2020, 221: 151-158. doi: 10.1016/j.jpeds.2020.03.007
[50]	PERKIOMAKI N, AUVINEN J, TULPPO M P, et al. Childhood growth patterns and cardiovascular autonomic modulation in midlife: northern Finland 1966 Birth Cohort Study[J]. Int J Obes(Lond), 2019, 43(11): 2264-2272. doi: 10.1038/s41366-019-0333-0
[51]	ROCHE J, QUINART S, THIVEL D, et al. Comparison between type A and type B early adiposity rebound in predicting overweight and obesity in children: a longitudinal study[J]. Br J Nutr, 2020, 124(5): 501-512. doi: 10.1017/S0007114520000987
[52]	GONZALEZ L, CORVALAN C, PEREIRA A, et al. Early adiposity rebound is associated with metabolic risk in 7-year-old children[J]. Int J Obes (Lond), 2014, 38(10): 1299-1304. doi: 10.1038/ijo.2014.97
[53]	SKINNER J D, BOUNDS W, CARRUTH B R, et al. Predictors of children's body mass index: a longitudinal study of diet and growth in children aged 2-8 y[J]. Int J Obes Relat Metab Disord, 2004, 28(4): 476-482. doi: 10.1038/sj.ijo.0802405
[54]	DI GRAVIO C, KRISHNAVENI G V, SOMASHEKARA R, et al. Comparing BMI with skinfolds to estimate age at adiposity rebound and its associations with cardio-metabolic risk markers in adolescence[J]. Int J Obes(Lond), 2019, 43(4): 683-690. doi: 10.1038/s41366-018-0144-8
[55]	FANG J, GONG C, SU P, et al. Polygenic interactions with adiposity rebound in the prediction of thelarche[J]. Pediatr Res, 2021, 89(4): 1026-1031. doi: 10.1038/s41390-020-1001-8
[56]	PENEAU S, GONZALEZ-CARRASCOSA R, GUSTO G, et al. Age at adiposity rebound: determinants and association with nutritional status and the metabolic syndrome at adulthood[J]. Int J Obes (Lond), 2016, 40(7): 1150-1156. doi: 10.1038/ijo.2016.39
[57]	WILLIAMS S M, GOULDING A. Patterns of growth associated with the timing of adiposity rebound[J]. Obesity(Silver Spring), 2009, 17(2): 335-341.
[58]	WADSWORTH M, BUTTERWORTH S, MARMOT M, et al. Early growth and type 2 diabetes: evidence from the 1946 british birth cohort[J]. Diabetologia, 2005, 48(12): 2505-2510. doi: 10.1007/s00125-005-0007-4
[59]	KOIVUAHO E, LARU J, OJANIEMI M, et al. Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS[J]. Int J Obes(Lond), 2019, 43(7): 1370-1379. doi: 10.1038/s41366-019-0318-z
[60]	TAYLOR R W, GRANT A M, GOULDING A, et al. Early adiposity rebound: review of papers linking this to subsequent obesity in children and adults[J]. Curr Opin Clin Nutr Metab Care, 2005, 8(6): 607-612. doi: 10.1097/01.mco.0000168391.60884.93
[61]	ARIS I M, RIFAS-SHIMAN S L, LI L J, et al. Patterns of body mass index milestones in early life and cardiometabolic risk in early adolescence[J]. Int J Epidemiol, 2019, 48(1): 157-167. doi: 10.1093/ije/dyy286
[62]	LAMMI N, MOLTCHANOVA E, BLOMSTEDT P A, et al. Childhood BMI trajectories and the risk of developing young adult-onset diabetes[J]. Diabetologia, 2009, 52(3): 408-414. doi: 10.1007/s00125-008-1244-0