儿童青少年孤独症谱系障碍与肥胖关联的累积Meta分析

李尧; 崔庭凯; 张欣

doi:10.16835/j.cnki.1000-9817.2022.06.027

儿童青少年孤独症谱系障碍与肥胖关联的累积Meta分析

doi: 10.16835/j.cnki.1000-9817.2022.06.027

天津医科大学公共卫生学院，天津 300070

基金项目:

国家自然科学基金项目 81773459

国家自然科学基金项目 81973070

详细信息

作者简介:
李尧(1996-)，女，辽宁葫芦岛人，在读硕士，主要研究方向为儿少卫生与妇幼保健

通讯作者:
张欣，E-mail：zhangxinty06@163.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R748 R723.14
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- 文章访问数: 538
- HTML全文浏览量: 218
- PDF下载量: 65
- 被引次数: 0
出版历程
- 收稿日期: 2022-02-11
- 修回日期: 2022-03-14
- 网络出版日期: 2022-06-23
- 刊出日期: 2022-06-25

Cumulative Meta-analysis of the association between obesity and autism spectrum disorders in children and adolescents

School of Public Health, Tianjin Medical University, Tianjin (300070), China

摘要

摘要: 目的对肥胖和孤独症谱系障碍(ASD)流行病学研究进行Meta分析，以探究儿童青少年孤独症谱系障碍和肥胖之间的关联，为改善ASD儿童青少年患者日常生活质量提供一定指导作用。方法系统检索PubMed、CNKI(2010年1月—2022年1月)中与肥胖、ASD相关的文献，采用Meta分析报告OR值。并对权重、体质量指数(BMI)获得方式、年龄等分类指标进行亚组分析。结果共筛选11篇文献纳入分析，总样本包括336 830名参与者，其中ASD患者58 187名，正常发育者278 643名。经Meta分析，与正常人相比，ASD儿童青少年有更高的肥胖发病风险(OR=1.80，95%CI=1.74~1.86)。根据BMI获得方式分组后，与正常人相比，BMI由客观测量、从病历中获得、父母报告获得的ASD患者有更高的肥胖发病风险，OR值(OR值95%CI)分别为1.43(1.04~1.96)，5.23(4.44~6.16)，2.57(1.79~3.69)。根据年龄分组后，与正常人相比，14~20岁ASD儿童青少年患者有更高的肥胖发病风险，OR值(OR值95%CI)=2.19(1.21~3.94)。结论相较于正常发育同龄人，ASD儿童青少年患者发生肥胖的风险更高。应在饮食、体力活动方面正确引导ASD患者，尤其是在青春期，避免其发生肥胖及肥胖引起的其他疾病。
- 孤独性障碍 /
- 肥胖症 /
- Meta分析 /
- 儿童 /
- 青少年
Abstract: Objective This study conducts a Meta-analysis on the epidemiological studies of obesity and autism spectrum disorder (ASD) in order to explore the relationship between autism spectrum disorder and obesity in children and adolescents, and to provide some guidance for improving the quality of daily life of children and adolescents with ASD. Methods PubMed and CNKI (January, 2010-January, 2022) were systematically searched for literature related to autism spectrum disorders reported the or value by Meta-analysis, and compared the weight, BMI acquisition method. Results A total of 11 literatures were selected for analysis. The total sample included 336 830 participants, including 58 187 patients with ASD and 278 643 patients with normal development. Through Meta-analysis, children and adolescents with ASD had a higher risk of obesity than normal people (OR=1.80, 95%CI=1.74-1.86). when stratified by BMI acquisition, autistic patients with BMI obtained from objective measurement, medical records and parents' reports had a higher risk of obesity than normal people, and the OR value (95%CI) was 1.43(1.04-1.96), 5.23(4.44-6.16), 2.57(1.79-3.69). When stratified by age, children and adolescents with ASD aged 14 to 20 years had a higher risk of obesity than normal people. The OR value (95%CI) was 2.19(1.21-3.94). Conclusion Compared with healthy peers, children and adolescents with ASD have a higher risk of obesity. ASD patients need guidance in diet and physical activity, especially in adolescence, to prevent obesity or diseases caused by obesity.
- Autistic disorder /
- Obesity /
- Meta-analysis /
- Child /
- Adolescent
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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图 1 文献筛选流程

Figure 1. Flow chart of literature retrievald

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表 1 纳入文献的基本资料

Table 1. Basic data included in the study

第一作者与发表时间	国家	年龄/岁	ASD人数	正常发育人数	OR值(OR值95%CI)	ASD诊断方法	BMI获得方式	纽卡斯尔-渥太华评估总分
Barnhill^[12](2016)	美国	3~8	86	57	1.33(0.38~4.66)	SCQ，ADI-R，ADOS	客观测量	6
Bicer^[13](2016)	美国	6~8	118	97	1.77(1.02~3.09)	DSM-IV，DSM-V	客观测量	8
Broder-Fingert^[4](2014)	美国	2~20	2 976	3 696	5.23(4.44~6.16)	ICD-9	从病历中获得	7
Castro^[14](2016)	巴西	6~13	49	49	2.58(1.02~6.52)	DSM-IV	客观测量	6
Hill^[15](2015)	美国	2~17	5 053	8 844	1.10(1.00~1.20)	DSM-IV，ADOS	客观测量	8
Kummer^[16](2016)	巴西	4~12	69	19	5.00(0.62~40.56)	DSM-V	客观测量	7
Liu^[17](2016)	中国	3~7	154	73	0.42(0.19~0.91)	DSM-V	客观测量	8
Phillips^[18](2014)	美国	12~17	93	8 141	3.16(2.04~4.90)	父母报告	父母报告	6
Rimmer^[19](2010)	美国	14~16	159	12 973	2.18(1.51~3.13)	父母报告	父母报告	6
Shedilock^[20](2016)	美国	2~18	48 762	243 810	1.85(1.78~1.92)	ICD-9-CM	客观测量	8
Levy^[21](2019)	美国	2~5	668	884	1.57(1.24~2.00)	ADOS，SCQ，ADI-R，DSM-V	客观测量	7
注：SCQ为社会沟通问卷，ADI-R为孤独症诊断访谈量表(修订版)，ADOS为孤独症诊断观察时间表，DSM-IV为《诊断和统计手册》第4版，DSM-V为《诊断和统计手册》第5版，ICD-9为《国际疾病分类》第9版修订，ICD-9-CM为《国际疾病分类》第9版修订的临床修改。

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