留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

注意缺陷多动障碍儿童神经影像学研究进展

张可馨 张功

张可馨, 张功. 注意缺陷多动障碍儿童神经影像学研究进展[J]. 中国学校卫生, 2022, 43(5): 796-800. doi: 10.16835/j.cnki.1000-9817.2022.05.037
引用本文: 张可馨, 张功. 注意缺陷多动障碍儿童神经影像学研究进展[J]. 中国学校卫生, 2022, 43(5): 796-800. doi: 10.16835/j.cnki.1000-9817.2022.05.037
ZHANG Kexin, ZHANG Gong. Neuroimaging characteristics of children with different subtypes of attention-deficit/hyperactivity disorder[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(5): 796-800. doi: 10.16835/j.cnki.1000-9817.2022.05.037
Citation: ZHANG Kexin, ZHANG Gong. Neuroimaging characteristics of children with different subtypes of attention-deficit/hyperactivity disorder[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(5): 796-800. doi: 10.16835/j.cnki.1000-9817.2022.05.037

注意缺陷多动障碍儿童神经影像学研究进展

doi: 10.16835/j.cnki.1000-9817.2022.05.037
基金项目: 

内蒙古自治区高等学校科学研究项目 NJSY21562

详细信息
    作者简介:

    张可馨(1998-),女,内蒙古包头人,大学本科,主要研究方向为注意缺陷多动障碍认知机制及干预

    通讯作者:

    张功,E-mail:1835398626@qq.com

  • 利益冲突声明   所有作者声明无利益冲突。
  • 王苗苗
  • 中图分类号: R748 R445 R179

Neuroimaging characteristics of children with different subtypes of attention-deficit/hyperactivity disorder

  • 摘要: 注意缺陷多动障碍(attention-deficit/hyperactivity disorder, ADHD)是儿童期一种常见的神经发育障碍,不同亚型患者在共病及其行为、情感和认知功能方面存在显著差异。以磁共振成像技术(MRI)、脑电图(EEG)为主的神经影像学技术能为ADHD儿童诊断和干预提供客观有效的信息。从大脑工作的整体性与分离性出发,结合EEG与MRI两类技术进行定性、定量研究,可发现不同亚型间ADHD儿童脑结构功能特点存在差异,对提高ADHD诊断率,改善治疗效果有一定意义。
    1)  利益冲突声明   所有作者声明无利益冲突。
    2)  王苗苗
  • [1] THOMAS R, SANDERS S, DOUST J, et al. Prevalence of attention-deficit/hyperactivity disorder: a systematic review and Meta-analysis[J]. Pediatrics, 2015, 135(4): 994-1001. doi: 10.1542/peds.2014-3482
    [2] 李世明, 冯为, 方芳, 等. 中国儿童注意缺陷多动障碍患病率Meta分析[J]. 中华流行病学杂志, 2018, 39(7): 993-998. doi: 10.3760/cma.j.issn.0254-6450.2018.07.024

    LI S M, FENG W, FANG F, et al. Prevalence of attention deficit and hyperactivity disorder in children in China: a systematic review and Meta-analysis[J]. Chin J Epidemiol, 2018, 39(7): 993-998. doi: 10.3760/cma.j.issn.0254-6450.2018.07.024
    [3] KEMPER A R, MASLOW G R, HILL S, et al. Attention deficit hyperactivity disorder: diagnosis and treatment in children and adolescents[M]. Rockville(MD): Agency for Healthcare, 2018.
    [4] SIBLEY M H, SWANSON J M, ARNOLD L, et al. Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity[J]. J Child Psychol Psychiatry, 2017, 58(6): 655-662. doi: 10.1111/jcpp.12620
    [5] YAN L, JIANG W, DU Y, et al. Relations hips between behavioral symptoms of non-medicated Chinese children with attention deficit hyperactivity disorder and parenting stress: comparison of different subtypes and comorbidities[J]. Asia Pac Psychiatry, 2015, 8(2): 127-135.
    [6] 李长斌. 基于脑活动网络特征的ADHD分类研究[D]. 北京: 北京交通大学, 2014.

    LI C B. Research on classification of ADHD based on the characteristics in brain activity-network[D]. Beijing: Beijing Jiaotong University, 2014.
    [7] ROSTAMI M, FARASHI S, KHOSROWABADI R, et al. Discrimination of ADHD subtypes using decision tree on behavioral, neuropsychological and neural markers[J]. Basic Clin Neurosci, 2019, 11(3): 359-367.
    [8] SILK T J, VILGIS V, ADAMSON C, et al. Abnormal asymmetry in frontostriatal white matter in children with attention deficit hyperactivity disorder[J]. Brain Imag Behav, 2015, 10(4): 1-10.
    [9] WU Z M, BRALTEN J, CAO Q J, et al. White matter microstructural alterations in children with ADHD: categorical and dimensional perspectives[J]. Neuropsychopharmacology, 2017, 42(2): 572-580. doi: 10.1038/npp.2016.223
    [10] KRAIN A L, CASTELLANOS F X. Brain development and ADHD[J]. Clin Psychol Rev, 2006, 26(4): 433-444. doi: 10.1016/j.cpr.2006.01.005
    [11] JAGGER-RICKELS A C, KIBBY M Y, CONSTANCE J M. Global gray matter morphometry differences between children with reading disability, ADHD, and comorbid reading disability/ADHD[J]. Brain Lang, 2018, 185(4): 54-66.
    [12] ARIRA Y, MIKIMASA O, AYAKO F, et al. Age-related differences in frontal lobe function in children with ADHD[J]. Brain Dev Jpn, 2019, 41(7): 577-586. doi: 10.1016/j.braindev.2019.03.006
    [13] 曹阳. 注意缺陷多动障碍患儿执行功能与静息态脑功能影像特征的研究[D]. 上海: 上海交通大学, 2020.

    CAO Y. Association study on executive function and brain imaging in children with attention deficit hyperactivity disorder[D]. Shanghai: Shanghai Jiao Tong University, 2020.
    [14] HOOGMAN D, BRALTEN J, HIBAR D P, et al. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional Mega-analysis[J]. Lancet Psychiatry, 2017, 4(4): 310-319. doi: 10.1016/S2215-0366(17)30049-4
    [15] SAMEA F, SOLUKI S, NEJATI V, et al. Brain alterations in children/adolescents with ADHD revisited: a neuroimaging Meta-analysis of 96 structural and functional studies[J]. Neurosci Biobehav Rev, 2019, 100: 1-8. doi: 10.1016/j.neubiorev.2019.02.011
    [16] WYCISZKIEWICZ A, PAWLAK M A, KRAWIEC K. Cerebellar volume in children with Attention-Deficit Hyperactivity Disorder(ADHD)[J]. J Child Neurol, 2017, 32(2): 215-221. doi: 10.1177/0883073816678550
    [17] GAO Y, SHUAI D, BU X, et al. Impairments of large-scale functional networks in attention-deficit/hyperactivity disorder: a Meta-analysis of resting-state functional connectivity[J]. Psychol Med, 2019, 49(15): 1-11.
    [18] 杨莉. 注意缺陷多动障碍2017-2019年研究现状与展望[J]. 中国心理卫生杂志, 2020, 34(7): 594-601. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXWS202007010.htm

    YANG L. Advances and perspectives on attention-defict/hyperactivity disorder from 2017-2019[J]. Chin Ment Health J, 2020, 34(7): 594-601. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXWS202007010.htm
    [19] 孙悦, 钟苑心, 杨莉, 等. 脑功能连接特征判别青少年注意缺陷多动障碍的探索[J]. 中国心理卫生杂志, 2020, 34(2): 81-86. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXWS202002001.htm

    SUN Y, ZHONG Y X, YANG L, et al. Preliminary study on diagnosis of adolescents with attention-defict/hyperactivity disorder (ADHD) by brain functional connection characteristics[J]. Chin Ment Health J, 2020, 34(2): 81-86. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXWS202002001.htm
    [20] 巢羽桐, 张功. 运动干预对注意缺陷多动障碍儿童脑执行功能的影响[J]. 教育生物学杂志, 2021, 9(2): 152-159. doi: 10.3969/j.issn.2095-4301.2021.02.014

    CHAO Y T, ZHANG G. Efferts of exercise intervention on brain executive function of attention-defict/hyperactivity disorder children[J]. J Biol Educ, 2021, 9(2): 152-159. doi: 10.3969/j.issn.2095-4301.2021.02.014
    [21] 程硕, 李金花, 王和平. 关于注意缺陷多动障碍的病理研究进展[J]. 现代特殊教育, 2018, 331(4): 29-34. doi: 10.3969/j.issn.1004-8014.2018.04.010

    CHENG S, LI J H, WANG H P. Advances in research into pathology of attention deficit hyperactivity disorder[J]. Mod Spec Educ, 2018, 331(4): 29-34. doi: 10.3969/j.issn.1004-8014.2018.04.010
    [22] 连琼霞, 王真真, 张娟, 等. 注意缺陷多动障碍不同亚型儿童行为问题和社会生活能力分析[J]. 中国临床新医学, 2021, 14(1): 78-82. doi: 10.3969/j.issn.1674-3806.2021.01.15

    LIAN Q X, WANG Z Z, ZHANG J, et al. Analysis of different subtypes of behavior problem and social living ability in children with attention deficit hyperacitivity disorder[J]. Chin J New Clin Med, 2021, 14(1): 78-82. doi: 10.3969/j.issn.1674-3806.2021.01.15
    [23] LOGUE S F, GOULD T J. The neural and genetic basis of executive function: attention, cognitive flexibility, and response inhibition[J]. Pharmacol Biochem Behav, 2014, 123: 45-54. doi: 10.1016/j.pbb.2013.08.007
    [24] 李晓兰, 买合甫来提·坎吉. 两亚型ADHD儿童视听觉状态调节能力与反应抑制能力特点[J]. 中国特殊教育, 2014(7): 72-79. doi: 10.3969/j.issn.1007-3728.2014.07.012

    LI X L, MAIHEFULAITI K J. The state regulation and reaction inhibition among children with two subtypes of ADHD in there audio and visual channels[J]. Chin J Spec Educ, 2014(7): 72-79. doi: 10.3969/j.issn.1007-3728.2014.07.012
    [25] 关霖, 何凡, 陈思简, 等. 注意缺陷多动障碍儿童任务转换特点及不同亚型的比较[J]. 中国医刊, 2020, 55(7): 787-790. doi: 10.3969/j.issn.1008-1070.2020.07.029

    GUAN L, HE F, CHEN S J, et al. Comparison of task switching characteristics and subtypes of attention deficit hyperactivity disorder in children[J]. Chin J Med, 2020, 55(7): 787-790. doi: 10.3969/j.issn.1008-1070.2020.07.029
    [26] ZHANG H F, SHUAI L, ZHANG J S, et al. Neuropsychological profile related with executive function of Chinese preschoolers with attention-deficit/hyperactivity disorder neuropsychological measures and behavior rating scale of executive function-preschool version[J]. Chin Med J, 2018, 131(6): 648-656. doi: 10.4103/0366-6999.226893
    [27] 杨良政. 神经电生理检测在儿童注意缺陷多动障碍临床诊断中的应用[D]. 济南: 山东大学, 2015.

    YANG L Z. Neural electrophysiological test in diagnosis of children with attention-deficit/hyperactivity disorder[D]. Jinan: Shandong University, 2015.
    [28] AHMADI M, KAZEMI K, KUC K, et al. Cortical source analysis of resting state EEG data in children with attention deficit hyperactivity disorder[J]. Clin Neurophysiol, 2020, 131(9): 1-35.
    [29] DIAMOND A. Attention-deficit disorder(attention-deficit/hyperactivity disorder without hyperactivity): a neurobiologically and behaviorally distinct disorder from attention-deficit/hyperactivity disorder (with hyperactivity)[J]. Dev Psychopathol, 2005, 17(3): 807-825.
    [30] 杨润许. 学龄期注意缺陷多动障碍的静息态脑功能磁共振研究[D]. 昆明: 昆明医科大学, 2014.

    YANG R X. A resting-state brain function study of school-aged children with attention-deficit/hyperactivity disorder based on functional magnetic resonence imaging[D]. Kunming: Kunming Medical University, 2014.
    [31] 曹庆久, 臧玉峰, 王玉凤. 不同亚型注意缺陷多动障碍儿童静息态的脑功能磁共振研究[J]. 北京大学学报(医学版), 2007, 39(3): 261-265. doi: 10.3321/j.issn:1671-167X.2007.03.012

    CAO Q J, ZANG Y F, WANG Y F. Brain functions in attention deficit hyperactivity disorder combined and inattentive subtypes: a resting-state functional magnetic resonance imaging study[J]. J Peking Univ(Health Sci), 2007, 39(3): 261-265. doi: 10.3321/j.issn:1671-167X.2007.03.012
    [32] PIKUSA M, JONCZYK R. Functional abnormalities in Broca's area in adolescents with ADHD: a resting-state fMRI study[J]. Poz Stud Contemp Lin, 2015, 51(1): 163-177.
    [33] AL-AMIN M, ZINCHENKO A, GEYER T. Hippocampal subfield volume changes in subtypes of attention-deficit hyperactivity disorder[J]. Brain Res, 2018, 1685: 1-8. doi: 10.1016/j.brainres.2018.02.007
    [34] SEMRUD-CLIKEMAN M, FINE J G, BLEDSOE J, et al. Regional volumetric differences based on structural MRI in children with two subtypes of ADHD and controls[J]. J Atten Disord, 2017, 21(12): 1040-1049. doi: 10.1177/1087054714559642
    [35] ANDERSON A, DOUGLAS P K, KERR W T, et al. Non-negative matrix factorization of multimodal MRI, fMRI and phenotypic data reveals differential changes in default mode subnetworks in ADHD[J]. Neuroimage, 2014, 102: 207-219. doi: 10.1016/j.neuroimage.2013.12.015
    [36] VILGIS V, SUN L, CHEN J, et al. Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type[J]. Psychiat Res Neuroim, 2016, 254: 119-126. doi: 10.1016/j.pscychresns.2016.06.008
    [37] SVATKOVA A, NESTRASIL I, RUDSER K, et al. Unique white matter microstructural patterns in ADHD presentations-a diffusion tensor imaging study[J]. Hum Brain Mapp, 2016, 37(9): 3323-3336. doi: 10.1002/hbm.23243
    [38] LEI D, MA J, DU X, et al. Microstructural abnormalities in the combined and inattentive subtypes of attention-deficit hyperactivity disorder: a diffusion tensor imaging study[J]. Sci Rep, 2014, 4: 1-7.
    [39] HONG S B, ZALESKY A, FORNITO A, et al. Connectomic disturbances in attention-deficit/hyperactivity disorder: a whole-brain tractography analysis[J]. Biol Psychiat, 2014, 76(8): 656-663. doi: 10.1016/j.biopsych.2013.12.013
    [40] SANEFUJI M, CRAIG M, PARLATINI V, et al. Double-dissociation between the mechanism leading to impulsivity and inattention in attention deficit hyperactivity disorder: a resting state functional connectivity study[J]. Cortex, 2017, 86: 290-302. doi: 10.1016/j.cortex.2016.06.005
    [41] FAIR D A, NIGG J T, IYER S, et al. Distinct neural signatures detected for ADHD subtypes after controlling for micro-movements in resting state functional connectivity MRI data[J]. Front Syst Neurosci, 2013, 6: 1-31.
    [42] DOS S S A, BIAZOLI J C E, COMFORT W E, et al. Abnormal functional resting-state networks in ADHD: graph theory and pattern recognition analysis of fMRI data[J]. Biomed Res Int, 2014, 2014: 1-10.
    [43] ORINSTEIN A J, STEVENS M C. Brain activity in predominantly-inattentive subtype attention-deficit/hyperactivity disorder during an auditory oddball attention task[J]. Psychiat Res Neuroim, 2014, 223(2): 121-128. doi: 10.1016/j.pscychresns.2014.05.012
    [44] TAMM L, MENON V, REISS A L. Parietal attentional system aberrations during target detection in adolescents with attention deficit hyperactivity disorder: event-related fMRI evidence[J]. Am J Psychiatry, 2006, 163(6): 1033-1043. doi: 10.1176/ajp.2006.163.6.1033
    [45] STEVENS M C, PEARLSON G D, KIEHL K A. An fMRI auditory oddball study of combined-subtype attention deficit hyperactivity disorder[J]. Am J Psychiat, 2007, 164(11): 1737-1749. doi: 10.1176/appi.ajp.2007.06050876
    [46] SOLANTO M V, SCHULZ K P, FAN J, et al. Event-related fMRI of inhibitory control in the predominantly inattentive and combined subtypes of ADHD[J]. J Neuroim, 2009, 19(3): 205-212. doi: 10.1111/j.1552-6569.2008.00289.x
    [47] SAAD J F, GRIFFITHS K R, KORGAONKAR M S. A systematic review of imaging studies in the combined and inattentive subtypes of attention deficit hyperactivity disorder[J]. Front Integr Neurosc, 2020, 14: 1-14. doi: 10.3389/fnint.2020.00001
    [48] ARECES D, RODRIGUEZ C, GARCIA T, et al. Is an ADHD Observation-scale based on DSM criteria able to predict performance in a virtual reality continuous performance test?[J]. Appl Sci, 2020, 10(7): 1-8.
  • 加载中
计量
  • 文章访问数:  397
  • HTML全文浏览量:  248
  • PDF下载量:  39
  • 被引次数: 0
出版历程
  • 收稿日期:  2021-11-19
  • 修回日期:  2022-01-07
  • 网络出版日期:  2022-05-20
  • 刊出日期:  2022-05-25

目录

    /

    返回文章
    返回