母亲妊娠期疾病对青少年抑郁情绪的影响

焦婷; 邓纳莉; 郭霜霜; 杨杰文; 唐杰

doi:10.16835/j.cnki.1000-9817.2022.05.023

母亲妊娠期疾病对青少年抑郁情绪的影响

doi: 10.16835/j.cnki.1000-9817.2022.05.023

1.
广州医科大学公共卫生学院, 广东 511436
2.
广州市中小学卫生健康促进中心
3.
广州市社会福利院

基金项目:

广州医科大学"十四五"高峰学科建设项目 06-410-2107105

详细信息

作者简介:
焦婷(1996-), 女, 湖北十堰人, 在读硕士, 主要研究方向为青少年精神卫生

通讯作者:
唐杰, E-mail: gytanjie@163.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: G444 R179 B844.1
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- 被引次数: 0
出版历程
- 收稿日期: 2021-11-20
- 修回日期: 2021-12-19
- 网络出版日期: 2022-05-20
- 刊出日期: 2022-05-25

Impact of gestational complications on adolescent depression

1.
School of Public Health, Guangzhou Medical University, Guangzhou (511436), China

摘要

摘要: 目的了解广州市青少年抑郁情绪发生情况及母亲妊娠期疾病对青少年抑郁情绪的影响，为青少年抑郁的预防提供科学依据。方法采用分层整群随机抽样的方法，于2017年在广州市11个区抽取808所中小学，调查96 756名10~20岁青少年的父母他评抑郁症状以及母亲妊娠期疾病情况。结果父母他评青少年存在轻微、中度、重度抑郁情绪的发生率分别为5.5%，3.5%和0.5%。单因素分析显示，青少年抑郁情绪的严重程度与母亲妊娠期高血压、糖尿病、胆汁淤积症、甲状腺功能减退、甲状腺功能亢进、贫血、病毒性肝炎关联均有统计学意义(χ²=12.42~158.91，P值均 < 0.01)；多因素Logistic回归显示，母亲患有妊娠期糖尿病(OR=1.41，95%CI=1.18~1.68)、妊娠期甲状腺功能减低(OR=1.61，95%CI=1.15~2.26)、妊娠期甲状腺功能亢进(OR=1.40，95%CI=1.03~1.91)、妊娠期贫血(OR=1.46，95%CI=1.35~1.59)、妊娠期合并病毒性肝炎(OR=1.67，95%CI=1.38~2.02)与青少年父母他评抑郁严重程度呈正相关(P值均 < 0.05)。结论母亲妊娠期患糖尿病、甲状腺功能减退、甲状腺功能亢进、贫血以及病毒性肝炎可能对青少年抑郁情绪及严重性有影响。
- 妊娠 /
- 疾病 /
- 抑郁 /
- 情绪 /
- 回归分析 /
- 青少年
Abstract: Objective To investigate the incidence of adolescent depressive symptoms in primary and secondary schools in Guangzhou and the effect of gestational complications on adolescent depression, so to provide scientific basis for depression prevention among adolescent. Methods Stratified cluster random sampling method was used to select 808 primary and secondary schools in 11 districts of Guangzhou. A total of 96 756 parents of adolescents aged 10-20 were surveyed for adolescents depressive symptoms and maternal gestational complications. Results The parental reported rates of mild, moderate and major depressive symptoms of adolescents were 5.5%, 3.5%, and 0.5%, respectively. Univariate analysis showed that the severity of adolescent depression symptoms had statistical significance with maternal gestational hypertension, gestational diabetes mellitus, cholestasis, hypothyroidism, hyperthyroidism, gestational anemia and viral hepatitis (χ²=12.42~158.91, P < 0.01). Multivariate Logistic regression showed that maternal gestational diabetes mellitus (OR=1.41, 95%CI=1.18-1.68), hypothyroidism during pregnancy (OR=1.61, 95%CI=1.15-2.26), and hyperthyroidism during pregnancy (OR=1.40, 95%CI=1.03-1.91), anemia during pregnancy (OR=1.46, 95%CI=1.35-1.59), and viral hepatitis during pregnancy (OR=1.67, 95%CI=1.38-2.02) were positively correlated with the severity of adolescent depression symptoms reported by parents(P < 0.05). Conclusion Gestational diabetes mellitus, gestational hypothyroidism, gestational hyperthyroidism, gestational anemia and gestational viral hepatitis are associated with adolescent depressive symptom.
- Pregnancy /
- Disease /
- Depression /
- Emotions /
- Regression analysis /
- Adolescent
注释:

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表 1 青少年抑郁情绪他评严重程度与母亲妊娠期疾病的单因素分析

Table 1. Univariate analysis of gestational complications and the severity of adolescent depressive symptoms reported by parents

母亲妊娠期疾病	没有(n=87 606)	轻度(n=5 315)	中度(n=3 373)	重度(n=115)	合计(n=96 756)	χ²值	P值
高血压	1 184(1.4)	102(1.9)	59(1.7)	7(1.5)	1 352(1.4)	14.91	< 0.01
糖尿病	1 085(1.2)	95(1.8)	50(1.5)	20(4.3)	1 250(1.3)	46.57	< 0.01
胆汁淤积综合征	185(0.2)	22(0.40)	12(0.4)	2(0.4)	221(0.2)	12.42	< 0.01
甲状腺功能减退	216(0.2)	43(0.8)	17(0.5)	7(1.5)	283(0.3)	83.82	< 0.01
甲状腺功能亢进	289(0.3)	41(0.8)	26(0.8)	6(1.3)	362(0.4)	51.94	< 0.01
贫血	4 322(4.9)	416(7.8)	266(7.9)	47(10.2)	5 051(5.2)	158.91	< 0.01
病毒性肝炎	700(0.8)	81(1.5)	56(1.7)	10(2.2)	847(0.9)	64.45	< 0.01
注：( )内数字为检出率/%。

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表 2 母亲妊娠期疾病与青少年父母他评抑郁情绪严重程度有序多因素Logistic回归分析(n=96 756)

Table 2. Ordinal Logistic regression analysis of gestational complications and the severity of adolescent depressive symptoms reported by parents(n=96 756)

自变量	β值	Wald χ²值	OR值(OR值95%CI)	P值
妊娠期高血压	0.06	0.39	1.06(0.89~1.26)	0.54
妊娠期糖尿病	0.34	14.48	1.41(1.18~1.68)	< 0.01
妊娠期胆汁淤积综合征	-0.24	1.13	0.79(0.51~1.22)	0.29
妊娠期甲状腺功能减低	0.48	7.82	1.61(1.15~2.26)	0.01
妊娠期甲状腺功能亢进	0.34	4.57	1.40(1.03~1.91)	0.03
妊娠期贫血	0.38	79.60	1.46(1.35~1.59)	< 0.01
妊娠期病毒性肝炎	0.51	28.01	1.67(1.38~2.02)	< 0.01
注：各自变量均以否为参照组。

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参考文献(20)

[1]	王熙. 青春期抑郁性别差异及其执行控制功能的研究[D]. 合肥: 安徽医科大学, 2014. WANG X. The study on gender difference of depressive symptoms in adolescent students and their executive control function[D]. Hefei: Anhui Medical Unversity, 2014.
[2]	TANG X, TANG S, REN Z, et al. Prevalence of depressive symptoms among adolescents in secondary school in mainland China: a systematic review and Meta-analysis[J]. J Affect Disord, 2019, 245: 498-507. doi: 10.1016/j.jad.2018.11.043
[3]	邢超, 陶芳标. 儿童青少年抑郁与健康危害行为的关联[J]. 中国学校卫生, 2008, 29(1): 86-89. https://www.cnki.com.cn/Article/CJFDTOTAL-XIWS200801063.htm XING C, TAO F B. Association of depression and health-risk behaviors in children and adolescents[J]. Chin J Sch Health, 2008, 29(1): 86-89. https://www.cnki.com.cn/Article/CJFDTOTAL-XIWS200801063.htm
[4]	NOMURA Y, MARKS D J, GROSSMAN B, et al. Exposure to gestational diabetes mellitus and low socioeconomic status: effects on neurocognitive development and risk of attention-deficit/hyperactivity disorder in offspring[J]. Arch Pediatr Adolesc Med, 2012, 166(4): 337-43. doi: 10.1001/archpediatrics.2011.784
[5]	NAHUM SACKS K, FRIGER M, SHOHAM-VARDI I, et al. Long-term neuropsychiatric morbidity in children exposed prenatally to preeclampsia[J]. Early Hum Dev, 2019, 130: 96-100. doi: 10.1016/j.earlhumdev.2019.01.016
[6]	韩慧君, 魏珉. 母亲孕期甲状腺功能减低对子代智能的影响[J]. 新生儿科杂志, 2005, 20(6): 280-283. doi: 10.3969/j.issn.1673-6710.2005.06.016 HAN H J, WEI M. The influence of maternal hypothyroidism during pregnancy on offspring intelligence[J]. Chin J Neonatol, 2005, 20(6): 280-283. doi: 10.3969/j.issn.1673-6710.2005.06.016
[7]	YAMASAKI S, ANDO S, RICHARDS M, et al. Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: a population-based birth cohort study[J]. Schizophr Res, 2019, 206: 52-57. doi: 10.1016/j.schres.2018.12.016
[8]	吕雅杰, 赖丽娟, 李丹玲, 等. 广州市小学生体质健康监测系统问卷的信效度研究[J]. 中国妇幼保健, 2020, 35(8): 1511-1516. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202008049.htm LYU Y J, LAI L J, LI D L, et al. Study on the reliability and validity of physical health surveillance system questionnaire for primary school students in Guangzhou[J]. Matern Child Health Care China, 2020, 35(8): 1511-1516. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202008049.htm
[9]	刘书君. 长处和困难问卷(SDQ)中文版的信度和效度研究[D]. 成都: 四川大学, 2006. LIU S J. Reliability and validity of the Chinese version of the SDQ[D]. Chengdu: Sichuan University, 2006.
[10]	ERSKINE H E, BAXTER A J, PATTON G, et al. The global coverage of prevalence of data for mental disorders in children and adolescents[J]. Epidemiol Psychiatr Sci, 2017, 26(4): 395-342. doi: 10.1017/S2045796015001158
[11]	COMPARE A, ZARBO C, SHONIN E, et al. Emotional regulation and depression: a potential mediator between heart and mind[J]. Cardiovasc Psychiatry Neurol, 2014, 2014: 324374.
[12]	THAPAR A, COLLOSHAW S, PINE D S, et al. Depression in adolescence[J]. Lancet, 2012, 379(9820): 1056-1067. doi: 10.1016/S0140-6736(11)60871-4
[13]	苏朝霞, 康妍, 李建明. 青少年抑郁及其相关影响因素研究[J]. 中国健康心理学杂志, 2011, 19(5): 629-631. https://www.cnki.com.cn/Article/CJFDTOTAL-JKXL201105055.htm SU Z X, KANG Y, LI J M. Study on adolescent depression and the relevant risk factors[J]. Chin J Health Psychol, 2011, 19(5): 629-631. https://www.cnki.com.cn/Article/CJFDTOTAL-JKXL201105055.htm
[14]	WAHID S S, OTTMAN K, HUDHUD R, et al. Identifying risk factors and detection strategies for adolescent depression in diverse global settings: a Delphi Consensus Study[J]. J Affect Disord, 2021, 5(279): 66-74.
[15]	BOYD A, GOLDING J, MACLEOD J, et al. Cohort profile: the children of the 90 s: the index offspring of the Avon Longitudinal Study of Parents and Children[J]. Int J Epidemiol, 2013, 42(1): 111-127. doi: 10.1093/ije/dys064
[16]	WANG M J, DUNN E C, OKEREKE O I, et al. Maternal vitamin D status during pregnancy and offspring risk of childhood/adolescent depression: results from the Avon Longitudinal Study of Parents and Children (ALSPAC)[J]. J Affect Disord, 2020, 15(265): 255-262.
[17]	VAN DAM J M, GARRETT A J, SCHNEIDER L A, et al. Reduced cortical excitability, neuroplasticity, and salivary cortisol in 11-13-year-old children born to women with gestational diabetes mellitus[J]. E Bio Med, 2018, 31: 143-149.
[18]	GE G M, LEUNG M T Y, MAN K K C, et al. Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and Meta-analysis[J]. J Clin Endocr Metab, 2020, 105(12): dgaa555.
[19]	JANBEK J, SARKI M, SPECHT I O, et al. A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment[J]. Eur J Clin Nutr, 2019, 73(12): 1561-1578. doi: 10.1038/s41430-019-0400-6
[20]	DACHEW B A, SCOTT J G, BETTS K, et al. Hypertensive disorders of pregnancy and the risk of offspring depression in childhood: findings from the Avon Longitudinal Study of Parents and Children[J]. Dev Psychopathol, 2020, 32(3): 845-851. doi: 10.1017/S0954579419000944