大学生血尿酸增高与糖脂代谢的相关性

颜小挺; 李春胜; 葛伟伟; 刘海燕

doi:10.16835/j.cnki.1000-9817.2022.04.031

大学生血尿酸增高与糖脂代谢的相关性

doi: 10.16835/j.cnki.1000-9817.2022.04.031

1.
浙江省台州市中心医院(台州学院附属医院)护理部，318000
2.
台州市中心医院(台州学院附属医院)肾内科
3.
台州市中心医院(台州学院附属医院)骨科
4.
台州职业技术学院护理系

基金项目:

台州市科技局项目 20ywb51

浙江省康恩贝医院管理课题项目 2020ZHA-KEB334

浙江省教育厅一般科研项目 Y202044202

详细信息

作者简介:
颜小挺(1981-)，女，浙江台州人，大学本科，副主任护师，主要从事护理管理工作

利益冲突声明 所有作者声明无利益冲突。
中图分类号: G647.9 R446 R725.7
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出版历程
- 收稿日期: 2021-10-03
- 修回日期: 2022-01-05
- 网络出版日期: 2022-04-25
- 刊出日期: 2022-04-25

Correlation between higher serum uric acid and glycolipid metabolism in college students

1.
Nursing Department, Taizhou Central Hospital (Affiliated Hospital of Taizhou University), Taizhou (318000), Zhejiang Province, China

摘要

摘要: 目的探究大学生血尿酸增高流行病学特征及其与糖脂代谢相关性，为高校学生保健相关干预与教育提供参考。方法采用分层整群随机抽样法于2020年9月—2021年11月选取台州市2所高校989名大学生进行调查。分别采用尿素酶免疫法、酶联免疫吸附法检测受检者血尿酸(SUA)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、总胆固醇(TC)、三酰甘油(TG)水平。结果大学生血尿酸增高组腰围、体质量指数、收缩压、舒张压均高于正常组(t值分别为21.72，5.74，5.45，12.23，P值均 < 0.05)；血尿酸增高组SUA、FPG、TG、2 hPG、LDL、TC均高于正常组，HDL低于正常组(t值分别为29.40，23.97，10.24，7.62，34.91，8.27，-8.15，P值均 < 0.05)。Pearson相关分析发现，SUA水平与FPG、TG、2 hPG、LDL、TC水平均呈正相关，与HDL呈负相关(r值分别为0.63，0.72，0.69，0.16，0.81，-0.52，P值均 < 0.01)。将糖脂代谢指标纳入二分类多因素Logistic回归模型，结果显示，FPG、TG、LDL、TC与血尿酸增高发生均呈正相关，HDL与血尿酸增高发生呈负相关(P值均 < 0.05)。结论男性、饮酒、抽烟、血压上升易发生血尿酸增高，血尿酸增高的发生与糖脂代谢有相关性。
- 尿酸 /
- 葡萄糖 /
- 脂肪组织 /
- 代谢 /
- 回归分析 /
- 学生
Abstract: Objective To explore the epidemiological characteristics of elevated serum uric acid in college students and its association with glycolipid metabolism, providing reference for health care intervention and education of college students. Methods From September 2020 to November 2021, a retrospective study was conducted among 989 college students in Taizhou area by stratified cluster random sampling method, and a questionnaire was issued to all college students. Serum uric acid (SUA), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting plasma glucose(FPG), 2 h postprandial blood glucose (2 hPG), total cholesterol (TC), triglyceride (TG) levels were detected by urease immunoassay and enzyme-linked immunosorbent assay. Results Waist circumference, body mass index, systolic blood pressure and diastolic blood pressure in higher serum uric acid group were higher than those in normal group (t=21.72, 5.74, 5.45, 12.23, P < 0.05). The SUA, FPG, TG, 2 hPG, LDL and TC in serum uric acid increased group were higher than those in normal group, while HDL was lower than those in normal group (t=13.85, 23.97, 10.24, 7.62, 34.91, 8.27, -8.15, P < 0.05). Pearson correlation analysis showed that the levels of FPG, TG, 2 hPG, LDL and TC were positively correlated with SUA levels (r=0.63, 0.72, 0.69, 0.16, 0.81, P < 0.01). HDL was negatively correlated with SUA level (r=-0.52, P < 0.01). The glucolipid metabolism indexes were included into the binary Logistic regression model analysis, and the results showed that FPG, TG, LDL and TC were positively correlated with higher serum uric acid. HDL was negatively correlated with the incidence of higher serum uric acid (P < 0.05). Conclusion Male sex, alcohol consumption, smoking, and elevated blood pressure can contribute to higher serum uric acid, which has been found to be associated with glycolipid metabolism.
- Uric Acid /
- Glucose /
- Adipose tissue /
- Metabolism /
- Regression analysis /
- Students
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表 1 不同组别受检者糖脂代谢相关指标比较(x ±s)

Table 1. Comparison between subjects and indicators related to glucose and lipid metabolism(x ±s)

组别	人数	SUA/(μmol·L^-1)	FPG/(mmol·L^-1)	TG/(mmol·L^-1)	2 hPG/(mmol·L^-1)	HDL/(mmol·L^-1)	LDL/(mmol·L^-1)	TC/(mmol·L^-1)
血尿酸增高组	225	319.69±15.68	5.19±0.11	1.42±0.25	7.05±0.57	1.16±0.17	3.48±0.18	5.05±0.28
正常组	764	283.11±16.61	4.99±0.11	1.21±0.33	6.74±0.40	1.29±0.31	3.03±0.13	4.87±0.31
t值		29.40	23.97	10.24	7.62	-8.15	34.91	8.27
P值		< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01

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表 2 大学生血尿酸增高发生影响因素多元Logistic回归分析(n=989)

Table 2. Multivariate Logistic regression analysis of influencing factors of higher serum uric acid increase in college students(n=989)

自变量	β值	标准误	Wald χ²值	P值	OR值(OR值95%CI)
FPG	1.35	0.51	6.76	< 0.01	1.60(1.37~1.99)
TG	1.50	0.44	7.21	< 0.01	1.62(1.38~1.96)
2 hPG	1.48	0.62	6.94	< 0.01	1.60(1.51~2.03)
HDL	-1.25	0.60	7.36	< 0.01	0.79(0.62~0.99)
LDL	1.18	0.62	7.68	< 0.01	1.51(1.25~1.98)
TC	1.53	0.49	7.58	< 0.01	1.72(1.12~2.61)

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