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微塑料对儿童健康的影响

李明菊 李卓 白英龙 贾丽红 孙炜 潘国伟 闫灵均 杨佐森

李明菊, 李卓, 白英龙, 贾丽红, 孙炜, 潘国伟, 闫灵均, 杨佐森. 微塑料对儿童健康的影响[J]. 中国学校卫生, 2022, 43(2): 316-320. doi: 10.16835/j.cnki.1000-9817.2022.02.036
引用本文: 李明菊, 李卓, 白英龙, 贾丽红, 孙炜, 潘国伟, 闫灵均, 杨佐森. 微塑料对儿童健康的影响[J]. 中国学校卫生, 2022, 43(2): 316-320. doi: 10.16835/j.cnki.1000-9817.2022.02.036
LI Mingju, LI Zhuo, BAI Yinglong, JIA Lihong, SUN Wei, PAN Guowei, YAN Lingjun, YANG Zuosen. Impact of microplastics on children's health[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(2): 316-320. doi: 10.16835/j.cnki.1000-9817.2022.02.036
Citation: LI Mingju, LI Zhuo, BAI Yinglong, JIA Lihong, SUN Wei, PAN Guowei, YAN Lingjun, YANG Zuosen. Impact of microplastics on children's health[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(2): 316-320. doi: 10.16835/j.cnki.1000-9817.2022.02.036

微塑料对儿童健康的影响

doi: 10.16835/j.cnki.1000-9817.2022.02.036
基金项目: 

辽宁省教育厅项目 JC2019036

辽宁省“兴辽英才计划”项目 XLYC1802059

辽宁省重点研发计划项目 2019JH2/10300044

详细信息
    作者简介:

    李明菊(1997-),女,河南周口人,在读硕士,主要研究方向为不良环境因素对儿童健康的影响

    通讯作者:

    白英龙,E-mail: ylbai@cmu.edu.cn

  • 利益冲突声明  所有作者声明无利益冲突。
  • 中图分类号: R179 X505

Impact of microplastics on children's health

  • 摘要: 微塑料作为一种新型污染物,已引起学者广泛关注。儿童正处于生长发育的关键阶段,易受到微塑料的影响。研究概述了微塑料的来源和相关法律法规,详细介绍了微塑料进入人体的途径、近期研究中发现微塑料的一些毒性作用及其对儿童健康的潜在危害,以期为儿少卫生工作者提供研究思路。
    1)  利益冲突声明  所有作者声明无利益冲突。
  • 表  1  微塑料对身体系统的影响

    Table  1.   Impacts of microplastics in the organism

    系统 不良表现
    消化 破坏小肠显微结构,生长发育迟缓[55]; 肠道菌群失调,破坏屏障功能障碍[45]; 脂代谢、胆汁酸代谢异常[42-43, 45, 48]; 扰动能量代谢[42]
    呼吸 在肺组织中蓄积[30]; 破坏肺保护性屏障,诱发肺上皮细胞炎症[52, 56]和凋亡反应[56]; 影响肺泡上皮细胞活力,阻滞细胞周期[56]
    神经 可致线虫运动行为兴奋,神经退行性改变[54]
    循环 入血,随循环系统分布全身[42]
    生殖 影响精子生成、降低睾酮水平和破坏血-睾屏障[51]
    免疫 产生细胞毒性和炎性反应[52]; 提高细胞因子和组胺的表达水平[56]
    下载: 导出CSV
  • [1] Plastics Europe. Plastics-the Facts 2020, an analysis of European pla-stics production, demand and waste data[EB/OL]. (2021-01-23)[2021-10-11]. https://www.plasticseurope.org/en/resources/market-data.
    [2] THOMPSON R C, OLSEN Y, MITCHELL R P, et al. Lost at sea: where is all the plastic?[J]. Science, 2004, 304(5672): 838. doi: 10.1126/science.1094559
    [3] GALLO F, FOSSI C, WEBER R, et al. Marine litter plastics and microplastics and their toxic chemicals components: the need for urgent preventive measures[J]. Environ Sci Eur, 2018, 30(1): 1-14. doi: 10.1186/s12302-017-0129-6
    [4] LEI K, QIAO F, LIU Q, et al. Microplastics releasing from personal care and cosmetic products in China[J]. Mar Pollut Bull, 2017, 123(1/2): 122-126.
    [5] GASPERI J, WRIGHT S L, DRIS R, et al. Microplastics in air: are we breathing it in?[J]. Curr Opin Environ Sci Health, 2018, 1(No. C): 1-5. http://webhost.bridgew.edu/ebrush/CHEM%20489%20PDF/Journal%20Club/Blackmon-2.pdf
    [6] EFSA Panel on Contaminants in the Food Chain. Presence of microplastics and nanoplastics in food, with particular focus on seafood[J]. EFSA J, 2016, 14(6): 4501. http://orbit.dtu.dk/files/124373616/4501.pdf
    [7] HAN M, NIU X R, TANG M, et al. Distribution of microplastics in surface water of the lower Yellow River near estuary[J]. Sci Total Environ, 2020, 707: 135601. doi: 10.1016/j.scitotenv.2019.135601
    [8] 徐沛, 彭谷雨, 朱礼鑫, 等. 长江口微塑料时空分布及风险评价[J]. 中国环境科学, 2019, 39(5): 2071-2077. doi: 10.3969/j.issn.1000-6923.2019.05.035

    XU P, PENG G Y, ZHU L X, et al. Spatial-temporal distribution and pollution load of microplastics in the Changjiang Estuary[J]. Chin Environ Sci, 2019, 39(5): 2071-2077. doi: 10.3969/j.issn.1000-6923.2019.05.035
    [9] ZHANG K, XIONG X, HU H, et al. Occurrence and characteristics of microplastic pollution in Xiangxi bay of three gorges reservoir, China[J]. Environ Sci Technol, 2017, 51(7): 3794-3801. doi: 10.1021/acs.est.7b00369
    [10] 骆永明, 周倩, 章海波, 等. 重视土壤中微塑料污染研究防范生态与食物链风险[J]. 中国科学院院刊, 2018, 33(10): 1021-1030. https://www.cnki.com.cn/Article/CJFDTOTAL-KYYX201810003.htm

    LUO Y M, ZHOU Q, ZHANG H B, et al. Pay attention to research on microplastic pollution in soil for prevention of ecological and food chain risks[J]. Bull Chin Acad Sci, 2018, 33(10): 1021-1030. https://www.cnki.com.cn/Article/CJFDTOTAL-KYYX201810003.htm
    [11] OLIVERI C G, FERRANTE M, BANNI M, et al. Micro-and nano-plastics in edible fruit and vegetables. The first diet risks assessment for the general population[J]. Environ Res, 2020, 187: 109677. doi: 10.1016/j.envres.2020.109677
    [12] LI L Z, LUO Y M, LI R J, et al. Effective uptake of submicrometre plastics by crop plants via a crack-entry mode[J]. Nat Sustain, 2020, 3: 929-937. doi: 10.1038/s41893-020-0567-9
    [13] 朱逸宁, 徐项亮, 何一波, 等. 国内外微塑料法规现状[J]. 中国洗涤用品工业, 2020(8): 52-57. doi: 10.3969/j.issn.1672-2701.2020.08.010

    ZHU Y N, XU X L, HE Y B, et al. Status of regulations on microplastics in the domestic and overseas[J]. Chin Clean Ind, 2020(8): 52-57. doi: 10.3969/j.issn.1672-2701.2020.08.010
    [14] 生态环境部. 环境保护综合名录(2017年版)[EB/OL]. (2018-02-06)[2021-10-11]. http://www.mee.gov.cn/gkml/sthjbgw/qt/201802/t20180206_430933.html.

    Ministry of Ecology and Environment of the PRC. Comprehensive catalogue for environmental protection (2017)[EB/OL]. (2018-02-06)[2021-10-11]. http://english.mee.gov.cn/News_service/news_release/201802/t20180224_431714.shtml.
    [15] 国家发展改革委, 生态环境部. 关于进一步加强塑料污染治理的意见[A/OL]. (2020-01-16)[2021-01-23]. https://www.ndrc.gov.cn/xxgk/zcfb/tz/202001/t20200119_1219275.html.

    National Development and Reform Commission of the PRC, Ministry of Ecology and Environment of the PRC. Opinions on further strengthening the control of plastic pollution[A/OL]. (2020-01-16)[2021-01-23]. https://www.ndrc.gov.cn/xxgk/zcfb/tz/202001/t20200119_1219275.html.
    [16] VAN RAAMSDONK L W D, VAN DER ZANDE M, KOELMANS A A, et al. Current insights into monitoring, bioaccumulation, and potential health effects of microplastics present in the food chain[J]. Foods, 2020, 9(1): 72. doi: 10.3390/foods9010072
    [17] TOUSSAINT B, RAFFAEL B, ANGERS-LOUSTAU A, et al. Review of micro-and nanoplastic contamination in the food chain[J]. Food Addit Contam: Part A, 2019, 36(5): 639-673. doi: 10.1080/19440049.2019.1583381
    [18] PIVOKONSKY M, CERMAKOVA L, NOVOTNA K, et al. Occurrence of microplastics in raw and treated drinking water[J]. Sci Total Environ, 2018, 643: 1644-1651. doi: 10.1016/j.scitotenv.2018.08.102
    [19] SMITH M, LOVE D C, ROCHMAN C M, et al. Microplastics in seafood and the implications for human health[J]. Curr Environ Health Rep, 2018, 5(3): 375-386. doi: 10.1007/s40572-018-0206-z
    [20] KIM J S, LEE H J, KIM S K, et al. Global pattern of microplastics (MPs) in commercial food-grade salts: sea salt as an indicator of seawater MP pollution[J]. Environ Sci Technol, 2018, 52(21): 12819-12828. doi: 10.1021/acs.est.8b04180
    [21] FADARE O O, WAN B, GUO L H, et al. Microplastics from consumer plastic food containers: are we consuming it?[J]. Chemosphere, 2020, 253: 126787. doi: 10.1016/j.chemosphere.2020.126787
    [22] HERNANDEZ L M, XU E G, LARSSON H C E, et al. Plastic teabags release billions of microparticles and nanoparticles into tea[J]. Environ Sci Technol, 2019, 53(21): 12300-12310. doi: 10.1021/acs.est.9b02540
    [23] DING J F, LI J X, SUN C J, et al. An examination of the occurrence and potential risks of microplastics across various shellfish[J]. Sci Total Environ, 2020, 739: 139887. doi: 10.1016/j.scitotenv.2020.139887
    [24] COX K D, COVERNTON G A, DAVIES H L, et al. Human consumption of microplastics[J]. Environ Sci Technol, 2019, 53(12): 7068-7074. doi: 10.1021/acs.est.9b01517
    [25] COX K D, COVERNTON G A, DAVIES H L, et al. Correction to human consumption of microplastics[J]. Environ Sci Technol, 2020, 54(17): 10974. doi: 10.1021/acs.est.0c04032
    [26] LI D Z, SHI Y H, YANG L M, et al. Microplastic release from the degradation of polypropylene feeding bottles during infant formula preparation[J]. Nat Food, 2020, 1: 746-754. doi: 10.1038/s43016-020-00171-y
    [27] ZHANG J J, WANG L, KANNAN K. Polyethylene terephthalate and polycarbonate microplastics in pet food and feces from the United States[J]. Environ Sci Technol, 2019, 53(20): 12035-12042. doi: 10.1021/acs.est.9b03912
    [28] SCHWABL P, KÖPPEL S, KÖNIGSHOFER P, et al. Detection of various microplastics in human stool: a prospective case series[J]. Ann Inte Med, 2019, 171(7): 453-457. doi: 10.7326/M19-0618
    [29] VIANELLO A, JENSEN R L, LIU L, et al. Simulating human exposure to indoor airborne microplastics using a Breathing Thermal Manikin[J]. Sci Rep, 2019, 9(1): 8670. doi: 10.1038/s41598-019-45054-w
    [30] PAULY J L, STEGMEIER S J, ALLAART H A, et al. Inhaled cellulosic and plastic fibers found in human lung tissue[J]. Cancer Epidemiol Biomark Prev, 1998, 7(5): 419-428. http://cebp.aacrjournals.org/content/7/5/419.full-text.pdf
    [31] PRATA J C, COSTA J P, LOPES I, et al. Environmental exposure to microplastics: an overview on possible human health effects[J]. Sci Total Environ, 2020, 702: 134455. doi: 10.1016/j.scitotenv.2019.134455
    [32] REVEL M, CHÂTEL A, MOUNEYRAC C. Micro(nano)plastics: a threat to human health?[J]. Curr Opin Environ Sci Health, 2018, 1(No. C): 17-23. http://www.researchgate.net/profile/Messika_Revel2/publication/321874398_Micronanoplastics_A_threat_to_human_health/links/5a788a6c0f7e9b41dbd42ea1/Micronanoplastics-A-threat-to-human-health.pdf
    [33] HABIB R Z, SALIM ABDOON M M, AL MEQBAALI R M, et al. Analysis of microbeads in cosmetic products in the United Arab Emirates[J]. Environ Pollut, 2019, 258: 113831. http://www.sciencedirect.com/science/article/pii/S0269749119346706
    [34] ABBASI S, TURNER A. Human exposure to microplastics: a study in Iran[J]. J Hazard Mater, 2021, 403: 123799. doi: 10.1016/j.jhazmat.2020.123799
    [35] CHANG X R, XUE Y Y, LI J Y, et al. Potential health impact of environmental micro-and nanoplastics pollution[J]. J Appl Toxicol, 2020, 40(1): 4-15. doi: 10.1002/jat.3915
    [36] DELLA T C, BERGAMI E, SALVATI A, et al. Accumulation and embryotoxicity of polystyrene nanoparticles at early stage of development of sea urchin embryos paracentrotus lividus[J]. Environ Sci Technol, 2014, 48(20): 12302-12311. doi: 10.1021/es502569w
    [37] BRADNEY L, WIJESEKARA H, PALANSOORIYA K N, et al. Particulate plastics as a vector for toxic trace-element uptake by aquatic and terrestrial organisms and human health risk[J]. Environ Int, 2019, 131: 104937. doi: 10.1016/j.envint.2019.104937
    [38] TOURINHO P S, KOĈÍ V, LOUREIRO S, et al. Partitioning of chemical contaminants to microplastics: sorption mechanisms, environmental distribution and effects on toxicity and bioaccumulation[J]. Environ Pollut, 2019, 252(Part B): 1246-1256. http://d.wanfangdata.com.cn/periodical/21f0dbf241b30d650c7e9196ce06fae8
    [39] LOBELLE D, CUNLIFFE M. Early microbial biofilm formation on marine plastic debris[J]. Mar Pollut Bull, 2011, 62(1): 197-200. doi: 10.1016/j.marpolbul.2010.10.013
    [40] WRIGHT S L, KELLY F J. Plastic and human health: a micro issue?[J]. Environ Sci Technol, 2017, 51(12): 6634-6647. doi: 10.1021/acs.est.7b00423
    [41] PENG L C, FU D D, QI H Y, et al. Micro-and nano-plastics in marine environment: source, distribution and threats: a review[J]. Sci Total Environ, 2020, 698: 134254. doi: 10.1016/j.scitotenv.2019.134254
    [42] DENG Y F, ZHANG Y, LEMOS B, et al. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure[J]. Sci Rep, 2017, 7: 46687. doi: 10.1038/srep46687
    [43] YANG Y F, CHEN C Y, LU T H, et al. Toxicity-based toxicokinetic/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice[J]. J Hazard Mater, 2019, 366: 703-713. doi: 10.1016/j.jhazmat.2018.12.048
    [44] DENG Y F, ZHANG Y, QIAO R X, et al. Evidence that microplastics aggravate the toxicity of organophosphorus flame retardants in mice (mus musculus)[J]. J Hazard Mater, 2018, 357: 348-354. doi: 10.1016/j.jhazmat.2018.06.017
    [45] LU L, WAN Z Q, LUO T, et al. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice[J]. Sci Total Environ, 2018, 631-632(1): 449-458. http://www.onacademic.com/detail/journal_1000040244733110_c000.html
    [46] LI B Q, DING Y F, CHENG X, et al. Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice[J]. Chemosphere, 2020, 244: 125492. doi: 10.1016/j.chemosphere.2019.125492
    [47] JIN Y X, LU L, TU W Q, et al. Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice[J]. Sci Total Environ, 2019, 649: 308-317. doi: 10.1016/j.scitotenv.2018.08.353
    [48] LUO T, WANG C Y, PAN Z H, et al. Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring[J]. Environ Sci Technol, 2019, 53(18): 10978-10992. doi: 10.1021/acs.est.9b03191
    [49] FORTE M, IACHETTA G, TUSSELLINO M, et al. Polystyrene nanoparticles internalization in human gastric adenocarcinoma cells[J]. Toxicology In Vitro, 2016, 31: 126-136. doi: 10.1016/j.tiv.2015.11.006
    [50] LIU X D, TIAN X D, XU X, et al. Design of a phosphinate-based bioluminescent probe for superoxide radical anion imaging in living cells[J]. Luminescence, 2018, 33(6): 1101-1106. doi: 10.1002/bio.3515
    [51] JIN H B, MA T, SHA X X, et al. Polystyrene microplastics induced male reproductive toxicity in mice[J]. J Hazard Mater, 2021, 401: 123430. doi: 10.1016/j.jhazmat.2020.123430
    [52] DONG C D, CHEN C W, CHEN Y C, et al. Polystyrene microplastic particles: in vitro pulmonary toxicity assessment[J]. J Hazard Mater, 2020, 385: 121575. doi: 10.1016/j.jhazmat.2019.121575
    [53] XU M K, HALIMU G, ZHANG Q R, et al. Internalization and toxicity: a preliminary study of effects of nanoplastic particles on human lung epithelial cell[J]. Sci Total Environ, 2019, 694: 133974. http://www.sciencedirect.com/science/article/pii/S0048969719337350
    [54] LEI L L, LIU M T, SONG Y, et al. Polystyrene (nano)microplastics cause size-dependent neurotoxicity, oxidative damage and other adverse effects in Caenorhabditis elegans[J]. Environ Sci-Nano, 2018, 5(8): 2009-2020. doi: 10.1039/C8EN00412A
    [55] 康恺, 杨丹, 黄至诚, 等. 微塑料对小鼠生长和小肠结构的影响[J]. 农业环境科学学报, 2020, 39(2): 256-262. https://www.cnki.com.cn/Article/CJFDTOTAL-NHBH202002006.htm

    KANG K, YANG D, HUANG Z C, et al. Effects of microplastics on the growth and structure of the mouse small intestine[J]. J Agroic Environ Sci, 2020, 39(2): 256-262. https://www.cnki.com.cn/Article/CJFDTOTAL-NHBH202002006.htm
    [56] HWANG J, CHOI D, HAN S, et al. An assessment of the toxicity of polypropylene microplastics in human derived cells[J]. Sci Total Environ, 2019, 684: 657-669. doi: 10.1016/j.scitotenv.2019.05.071
    [57] XIN Z, TSUDA T, DOIH. Evaluating the effects of air pollution from a plastic recycling facility on the health of nearby residents[J]. Acta Med Okayama, 2017, 71(3): 209-217. http://ousar.lib.okayama-u.ac.jp/files/public/5/55013/20170623145328100580/K0005460_fulltext.pdf
    [58] 郭小璇, 宋莉莉, 郑磊, 等. 杭州地区近年80620例儿童常见皮肤病特征分析[J]. 浙江医学, 2019, 41(15): 1650-1652. doi: 10.12056/j.issn.1006-2785.2019.41.15.2019-593

    GUO X X, SONG L L, ZHENG L, et al. Characteristic analysis of 80620 cases children's common dermatosis in Hangzhou[J]. Zhejiang Med J, 2019, 41(15): 1650-1652. doi: 10.12056/j.issn.1006-2785.2019.41.15.2019-593
    [59] OUÉDRAOGO A N, TRAORÉ F, KABORET N, et al. Le plastique du pot de toilette: une source d'eczéma de contact. Une série de 20 cas à Ouagadougou[J]. Revue Française d'Allergologie, 2019, 59(6): 454-456. doi: 10.1016/j.reval.2019.06.002
    [60] ZHANG Y P, LI B Z, HUANG C, et al. Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China[J]. Chin Sci Bull, 2013, 58(34): 4182-4189. doi: 10.1007/s11434-013-5914-z
    [61] NISHIMURA K K, GALANTER J M, ROTH L A, et al. Early-life air pollution and asthma risk in minority children. The GALA Ⅱ and SAGE Ⅱ studies[J]. Am J Resp Crit Care, 2013, 188(3): 309-318. doi: 10.1164/rccm.201302-0264OC
    [62] YANG H, XIONG H R, MI K H, et al. Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae[J]. J Hazard Mater, 2020, 388: 122058. doi: 10.1016/j.jhazmat.2020.122058
    [63] FOURNIER S B, D'ERRICO J N, ADLER D S. Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy[J]. Part Fibre Toxicol, 2020, 17(1): 55. doi: 10.1186/s12989-020-00385-9
    [64] RAGUSAA A, SVELATOA A, SANTACROCEB C, et al. Plasticenta: first evidence of microplastics in human placenta[J]. Environ Int, 2021, 146: 106274. doi: 10.1016/j.envint.2020.106274
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出版历程
  • 收稿日期:  2021-08-01
  • 修回日期:  2021-09-14
  • 网络出版日期:  2022-02-24
  • 刊出日期:  2022-02-25

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