大学生尿液金属水平与肺功能的关系

荣素英; 刘佳佳; 杨文琦; 曾豪; 张磊; 方波; 徐厚君; 王茜

doi:10.16835/j.cnki.1000-9817.2022.02.029

大学生尿液金属水平与肺功能的关系

doi: 10.16835/j.cnki.1000-9817.2022.02.029

荣素英¹,
刘佳佳²,
杨文琦³,
曾豪²,
张磊^{2, 4},
方波^{2, 5},
徐厚君²,
王茜^2, ,

1.
唐山职业技术学院临床医学系，河北 063000
2.
华北理工大学公共卫生学院
3.
华北理工大学附属医院心内二科
4.
首都医科大学劳动卫生与环境卫生教研室
5.
河南大学附属淮河医院办公室

基金项目:

河北省自然科学基金项目 H2021209054

唐山市科技计划项目 19130209g

详细信息

作者简介:
荣素英(1969-)，女，河北唐山人，硕士，副教授，主要从事预防医学相关教学与研究工作

通讯作者:
王茜，E-mail：wwqq517@aliyun.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R446 G647.8
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- 被引次数: 0
出版历程
- 收稿日期: 2021-08-31
- 修回日期: 2021-12-29
- 网络出版日期: 2022-02-24
- 刊出日期: 2022-02-25

Relationship between urinary metals and lung function in college students

RONG Suying¹,
LIU Jiajia²,
YANG Wenqi³,
ZENG Hao²,
ZHANG Lei^{2, 4},
FANG Bo^{2, 5},
XU Houjun²,
WANG Qian^{2
, ,}

1.
Department of Clinical Medicine, Tangshan Vocational and Technical College, Tangshan (063000), Hebei Province, China

摘要

摘要: 目的探讨大学生金属内暴露水平与肺功能的相关性，为开展金属暴露与肺功能损伤的相关研究提供依据。方法以2017—2018年在华北理工大学曹妃甸校区招募的45名符合标准的大学生为研究对象，分别于春、夏、秋、冬季进行问卷随访调查和健康体检，测量肺功能参数[用力肺活量(FVC)、1 s用力呼气容积(FEV1)、最大呼气流量(PEF)、FEV1/FVC和用力呼气流量(FEF_25~75)]，同时采集晨尿样本。尿液中15种金属含量使用电感耦合等离子体质谱法(ICP/MS)检测; 采用Kruskal-Wallis H检验比较不同季节尿液中金属含量的差异; 运用线性混合效应模型分析尿液中金属组分暴露浓度与肺功能之间的相关性。结果尿液15种金属元素中，铬、铁、镍、铜、锌、砷、硒、钼、镉、锑、铅在4个季节的含量差异均有统计学意义(H=9.79~20.61，P值均 < 0.05)。5项肺功能参数在4个季节的差异均有统计学意义(F值分别为61.72，45.30，47.61，25.47，35.13，P值均 < 0.05)。线性混合效应模型分析结果显示，尿液中钒、锰、铁、钴、镍和锑含量与FEV1呈负性相关(B值分别为0.202，0.192，0.181，0.154，0.131，0.283);尿液中铝、钒、锰、铁、钴、镍、锌、镉和锑的含量与FVC呈负性相关(B值分别为0.252，0.290，0.292，0.271，0.201，0.180，0.171，0.163，0.381);尿液中锰和锑的含量与PEF呈负相关(B值分别为0.291，0.354)(P值均 < 0.05)。结论大学生尿液中多种金属含量的增加与肺功能水平下降有关，金属元素的长期暴露有可能造成肺功能的损害，应加强对环境金属污染的控制。
- 尿 /
- 金属 /
- 肺 /
- 线性模型 /
- 学生
Abstract: Objective To explore the association between urinary metals and lung function among college students, and to provide a theoretical basis for related research on metal exposure and lung function injury. Methods A total of 45 healthy college students were recruited from North China University of Science and Technology in Caofeidian between 2017-2018. During the four seasons, information was obtained from questionnaires and physical examinations, lung function parameters were assessed, including FVC, FEV1, PEF, FEV1/FVC and FEF_25-75, and morning urine samples were collected simultaneously. The urinary levels of 15 metals were measured by inductively coupled plasma mass spectrometry (ICP/MS); a Kruskal-Wallis H test was used to compare differences in urinary metals during the four seasons; and a mixed effect model was used to assess correlations between urinary metals and lung function. Results There were significant differences in the levels of urinary chromium, iron, nickel, copper, zinc, arsenic, selenium, selenium, molybdenum, cadmium, antimony and lead from 15 metals over the four seasons (H=9.79-20.61, P < 0.05). The differences observed in five lung function parameters over the four seasons were statistically significant (F=61.72, 45.30, 47.61, 25.47, 35.13, P < 0.05). The linear mixed effect model analysis showed that urinary concentrations of vanadium, manganese, iron, cobalt, nickel and antimony were negatively correlated with FEV1(B=0.202, 0.192, 0.181, 0.154, 0.131, 0.283); urinary concentrations of aluminum, vanadium, manganese, iron, cobalt, nickel, zinc, cadmium, and antimony were negatively correlated with FVC (B=0.252, 0.290, 0.292, 0.271, 0.201, 0.180, 0.171, 0.163, 0.381); urinary concentrations of manganese and antimony were negatively correlated with PEF (B=0.291, 0.354)(P < 0.05). Conclusion The increase of multiple metal concentrations among college students was related to lung function decline, the long-term metal exposure might lead to lung function damage. So environmental metal pollution should be controlled.
- Urine /
- Metals /
- Lung /
- Linear models /
- Students
注释:

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表 1 不同季节大学生尿液中15种金属元素含量比较[M(IQR), μg/mmolCr，n=45]

Table 1. Comparison of urinary levels of 15 metals in four seasons among college students[M(IQR), μg/mmolCr, n=45]

季节	铝	钒	铬	锰	铁	钴	镍	铜
春	11.28(13.69)	0.16(0.20)	0.36(0.53)	1.07(1.35)	0.37(0.46)	0.78(1.45)	2.86(6.30)	7.59(10.91)
夏	10.83(15.44)	0.14(0.18)	0.44(0.46)	1.30(1.44)	0.45(0.58)	0.63(0.92)	2.78(5.30)	5.74(9.46)
秋	10.96(14.57)	0.13(0.20)	0.41(0.59)	0.89(1.65)	0.24(0.53)	0.63(0.93)	2.72(3.77)	6.57(11.24)
冬	13.74(17.96)	0.17(0.21)	0.59(0.86)	1.41(1.29)	0.51(0.77)	1.02(1.14)	4.87(5.82)	10.43(7.82)
H值	4.29	4.29	9.79	4.39	11.55	3.68	11.05	15.80
P值	0.23	0.23	0.02	0.22	0.01	0.30	0.01	< 0.01

季节	锌	砷	硒		钼	镉	锑	铅
春	326.71(595.21)	15.89(24.27)	21.43(31.47)		58.13(114.78)	0.24(0.29)	1.68(2.55)	1.75(2.70)
夏	327.44(394.45)	13.39(14.85)	14.72(23.20)		49.53(71.11)	0.18(0.34)	2.18(2.32)	1.56(1.30)
秋	273.64(472.55)	19.19(20.57)	22.66(29.51)		39.64(77.98)	0.22(0.27)	1.51(2.41)	1.76(2.66)
冬	528.11(458.83)	24.46(30.97)	37.13(37.16)		85.22(53.01)	0.34(0.39)	3.07(2.58)	2.46(2.40)
H值	9.94	11.04	20.61		14.69	12.61	17.73	15.97
P值	0.02	0.01	< 0.01		< 0.01	0.01	< 0.01	< 0.01

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表 2 不同季节大学生肺功能指标比较(x±s，n=45)

Table 2. The differences of lung function parameters of subjects in 4 seasons among college students(x±s, n=45)

季节	FVC/L	FEV1/L	PEF/(L·s^-1)	FEV1/FVC	FEF_25~75/(L·s^-1)
春	5.02±1.09	4.07±0.99	5.44±1.63	0.81±0.07	3.96±1.18
夏	3.43±0.88	2.89±0.77	3.12±1.34	0.85±0.13	2.57±1.07
秋	4.88±0.83	3.89±0.58	4.65±1.35	0.80±0.06	3.43±0.76
冬	3.83±1.03	3.33±0.92	4.55±1.70	0.87±0.06	3.89±1.55
F值	61.72	45.30	47.61	25.47	35.13
P值	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01

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