银川市中学生高三酰甘油腰围表型与血压异常的关系

蔡蓉蓉; 董洋洋; 周金玉; 白玲; 丁文清

doi:10.16835/j.cnki.1000-9817.2022.01.031

银川市中学生高三酰甘油腰围表型与血压异常的关系

doi: 10.16835/j.cnki.1000-9817.2022.01.031

宁夏医科大学公共卫生与管理学院/宁夏环境因素与慢性病控制重点实验室，银川 750004

基金项目:

国家自然科学基金项目 81660565

国家自然科学基金项目 82160641

详细信息

作者简介:
蔡蓉蓉(1995-)，女，陕西榆林人，在读硕士，主要研究方向为儿童青少年慢性流行病学

通讯作者:
丁文清，E-mail：dwqdz@163.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R544 R446
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- 被引次数: 0
出版历程
- 收稿日期: 2021-09-16
- 修回日期: 2021-12-02
- 刊出日期: 2022-01-25

Relationship between hypertriglyceridemic-waist phenotype and abnormal blood pressure in children and adolescents in Yinchuan City

School of Public Health and Management, Ningxia Medical University/Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan (750004), China

摘要

摘要: 目的探讨宁夏银川市城区儿童青少年高三酰甘油腰围(HTW)表型与血压异常的关系，为儿童青少年及成人期高血压的识别和防治提供科学依据。方法 2018—2020年采取整群抽样的方法，抽取银川市1 566名学龄儿童青少年作为研究对象，所有研究对象均完成问卷调查、体格测量和血液生化检验。结果调整年龄、吸烟、饮酒和高血压家族史后，总人群中与正常三酰甘油腰围(NWNT)表型学生相比，高腰围表型(EW)和HTW表型均增加了血压异常的风险(OR_EW=2.62，95%CI=1.87~3.67;OR_HTW=3.97，95%CI=2.30~6.86);EW和HTW表型男生的血压异常发生风险分别是NTNW表型男生的3.80(95%CI=2.35~6.15)和3.32倍(95%CI=1.59~6.92)，EW和HTW表型女生的血压异常发生风险分别是NTNW表型女生的1.72(95%CI=1.06~2.82)和4.62倍(95%CI=1.97~10.85)。结论银川市城区儿童青少年不同高三酰甘油腰围表型与血压异常风险增加显著相关。应及时关注儿童青少年的三酰甘油和腰围水平。
- 血压 /
- 身体测量 /
- ROC曲线 /
- 回归分析 /
- 学生
Abstract: Objective To investigate the relationship between hypertriglyceridemic-waist (HTW) phenotype and abnormal blood pressure in children and adolescents in Yinchuan City, Ningxia, and to provide scientific basis for early identification and prevention of hypertension. Methods A cluster sampling method was adopted to select 1 566 children and adolescents in Yinchuan. All participants completed questionnaire survey, physical measurement and biochemical examination. Results In general, after adjusting for age, smoking, drinking, and family history of hypertension, compared with the normal triglyceride normal waist (NWNT) phenotype, the enlarged waist (EW) and HTW phenotypes both increased the risk of abnormal blood pressure (OR_EW=2.62, 95%CI=1.87-3.67; OR_HTW=3.97, 95%CI=2.30-6.86); the risk of abnormal blood pressure in boys with EW and HTW phenotypes was that of boys with NTNW phenotype, respectively 3.80 times (95%CI=2.35-6.15) and 3.32 times (95%CI=1.59-6.92) of girls EW and HTW phenotypes. The risk of abnormal blood pressure in girls with EW and HTW phenotypes was that of girls with NTNW phenotype, respectively 1.72 times (95%CI=1.06-2.82) and 4.62 times(95%CI=1.97-10.85). Conclusion The hypertriglyceridemic-waist phenotypes among children and adolescents in Yinchuan is significantly correlated with increased risk of abnormal blood pressure. More attention should be paid to triglyceride level and waist circumference among children and adolescents.
- Blood pressure /
- Body size /
- ROC curve /
- Regression analysis /
- Students
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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表 1 不同性别中学生各HTW表型基线资料比较(x±s)

Table 1. Comparison of baseline data on each HIW pnenotype among secondary school students by gender(x±s)

性别	选项	人数	统计值	年龄/岁	身高/cm	身高-Z	体重/kg	体重-Z	BMI/ (kg·m^-2)	BMI-Z	WC/cm	WC-Z
男	NTNW	730		15.4±1.7	170.9±7.6	-0.13±0.98	55.3±7.9	-0.39±0.58	18.9±2.0	-0.40±0.54	69.4±4.8	-0.44±0.44
	HTG	61		15.8±1.7	171.8±6.9	-0.08±0.90	55.9±6.0	-0.40±0.45	19.0±1.8	-0.40±0.48	70.9±4.2	-0.34±0.39
	EW	152		14.9±1.5	174.6±6.8	0.49±0.88	78.2±11.2	1.38±0.81	25.7±3.1	1.40±0.83	89.1±8.7	1.47±0.81
	HTW	57		15.2±1.9	174.6±7.5	0.51±1.01	83.0±10.8	1.80±0.77	27.2±2.9	1.87±0.79	94.2±9.0	2.00±0.80
			F/H值	5.25	22.01	23.02	521.51	506.55	609.16	570.17	848.66	813.07
			P值	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01
女	NTNW	318		14.8±1.9	161.2±5.4	-0.22±0.92	48.3±4.9	-0.59±0.47	18.6±1.8	-0.57±0.51	69.1±3.9	-0.63±0.40
	HTG	33		14.6±1.9	159.9±5.9	-0.37±0.94	48.9±3.8	-0.52±0.42	19.2±1.8	-0.40±0.63	70.4±2.7	-0.45±0.35
	EW	175		15.1±1.8	164.7±5.7	0.39±0.98	62.9±8.1	0.89±0.84	23.3±2.8	0.82±0.85	82.3±6.7	0.92±0.81
	HTW	40		14.9±2.1	164.6±6.1	0.36±1.05	66.6±10.4	1.27±0.97	24.7±3.7	1.28±1.06	85.5±8.6	1.28±1.06
			F/H值	1.46	18.44	18.78	248.81	258.35	203.75	205.86	301.38	319.54
			P值	0.22	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01

性别	选项	人数	统计值	SBP/mm Hg	SBP-Z	DBP/mm Hg	DBP-Z	FPG/ (mmol·L^-1)	TG/ (mmol·L^-1)	TC/ (mmol·L^-1)	HDL-C/ (mmol·L^-1)	LDL-C/ (mmol·L^-1)
男	NTNW	730		111.0±10.4	-0.18±0.92	66.2±8.0	-0.14±0.96	4.75±0.74	0.84±0.68	3.85±0.86	1.43±0.35	2.13±0.71
	HTG	61		112.2±13.0	-0.10±1.16	68.0±7.5	0.03±0.93	5.23±1.19	1.66±1.58	4.43±1.05	1.46±0.49	2.46±0.86
	EW	175		120.2±10.8	0.60±0.95	70.2±7.4	0.37±0.90	4.86±0.64	1.00±0.78	3.86±0.81	1.24±0.28	2.26±0.72
	HTW	57		122.7±9.6	0.82±0.84	73.9±8.4	0.80±1.10	4.89±0.84	1.93±1.63	4.79±1.28	1.20±0.35	2.97±1.28
			F/H值	47.06	44.71	25.77	25.73	6.67	336.10	26.29	19.65	24.32
			P值	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01
女	NTNW	318		106.8±9.2	-0.15±0.91	67.9±7.3	-0.10±0.95	4.72±0.62	0.87±0.71	3.97±0.97	1.52±0.42	2.11±0.71
	HTG	33		102.8±7.7	-0.52±0.78	66.0±5.7	-0.34±0.71	5.07±1.10	1.66±1.52	4.69±1.54	1.74±0.78	2.47±1.02
	EW	175		110.2±10.2	0.22±1.01	69.7±8.4	0.13±1.06	4.63±0.50	0.95±0.76	4.06±0.83	1.43±0.33	2.26±0.72
	HTW	40		115.3±11.7	0.67±1.16	72.3±8.1	0.49±1.01	4.80±0.49	1.71±1.55	4.52±1.02	1.33±0.38	2.60±0.87
			F/H值	15.39	15.59	6.61	6.71	4.18	200.73	8.37	7.27	7.04
			P值	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01	< 0.01

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表 2 不同HTW表型与血压异常的二元Logistic回归分析

Table 2. Binary Logistic regression analysis of different HTW phenotypes and abnormal blood pressure

性别	自变量	模型1		模型2		模型3		模型4
性别	自变量	OR值(OR值95%CI)	P值	OR值(OR值95%CI)	P值	OR值(OR值95%CI)	P值	OR值(OR值95%CI)	P值
男	HTG	0.51(0.15~1.72)	0.28	0.57(0.17~1.91)	0.36	0.57(0.17~1.90)	0.36	0.67(0.17~1.90)	0.36
(n=1 000)	EW	4.00(2.49~6.43)	< 0.01	3.81(2.36~6.15)	< 0.01	3.81(2.36~6.16)	< 0.01	3.80(2.35~6.15)	< 0.01
	HTW	3.12(1.52~6.39)	< 0.01	3.28(1.58~6.81)	< 0.01	3.30(1.58~6.89)	< 0.01	3.32(1.59~6.92)	< 0.01
女	HTG	0.31(0.07~1.38)	0.13	0.30(0.07~1.25)	0.12	0.28(0.06~1.25)	0.10	0.29(0.07~1.29)	0.10
(n=566)	EW	1.54(0.96~2.46)	0.07	1.71(1.06~2.76)	0.03	1.76(1.08~2.85)	0.02	1.72(1.06~2.80)	0.03
	HTW	4.11(1.82~9.31)	< 0.01	4.37(1.88~10.14)	< 0.01	4.51(1.93~10.57)	< 0.01	4.62(1.97~10.85)	< 0.01
合计	HTG	0.43(0.17~1.09)	0.08	0.45(0.17~1.14)	0.09	0.43(0.17~1.11)	0.08	0.44(0.17~1.12)	0.08
(n=1 566)	EW	2.62(1.88~3.64)	< 0.01	2.64(1.89~3.69)	< 0.01	2.65(1.89~3.71)	< 0.01	2.62(1.87~3.67)	< 0.01
	HTW	3.63(2.14~6.16)	< 0.01	3.75(2.22~6.56)	< 0.01	3.93((2.28~6.79)	< 0.01	3.97(2.30~6.86)	< 0.01
注：模型1未调整，模型2调整年龄，模型3调整年龄、吸烟和饮酒，模型4调整年龄、吸烟和饮酒和高血压家族史。

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