中国1990—2019年儿童青少年哮喘疾病负担变化趋势

张偲莹; 高宗石; 吴丽宏; 田蓓蓓; 刘蒙; 陶芳标; 吴修龙

doi:10.16835/j.cnki.1000-9817.2022.01.028

中国1990—2019年儿童青少年哮喘疾病负担变化趋势

doi: 10.16835/j.cnki.1000-9817.2022.01.028

张偲莹¹,
高宗石²,
吴丽宏¹,
田蓓蓓²,
刘蒙^{1, 3},
陶芳标¹,
吴修龙^1, ,

1.
安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室，合肥 230032
2.
安徽医科大学第一临床医学院
3.
南通大学附属妇幼保健院儿童保健科

基金项目:

安徽医科大学引进人才博士科研启动经费 0303030201

详细信息

作者简介:
张偲莹(1999-)，女，江苏泰州人，在读硕士，主要研究方向为儿童青少年健康

通讯作者:
吴修龙，E-mail：wuxiulong6@126.com

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R193 R179 R725.6
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出版历程
- 收稿日期: 2021-10-25
- 修回日期: 2021-11-21
- 刊出日期: 2022-01-25

Trends in the asthma burden among children and adolescents in China from 1990-2019

1.
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/MOE Key Laboratory of Population Health across Life Cycle, Hefei (230032), China

摘要

摘要: 目的探索1990—2019年中国儿童青少年哮喘疾病负担变化趋势，为开展防控工作提供参考。方法基于2019年全球疾病负担研究，利用Joinpoint回归分析性别和年龄别哮喘疾病负担动态变化，与各级社会人口指数(SDI)国家平均水平比较; 并分析归因哮喘疾病负担的变化。结果标化1~19岁哮喘伤残调整寿命年(DALYs)率1990—2005年间先小幅降低后快速降低，由158.55/10万降至88.59/10万。其中，1990—1996年年度变化百分比(APC)为-1.7%，1996—2005年APC为-5.7%。2005—2017年DALYs率先缓慢升高后快速升高，2017—2019年DALYs率由176.18/10万降为126.79/10万。男生哮喘疾病负担高于女生，5~9岁组哮喘DALYs率高于其他年龄组。中国儿童青少年哮喘标化DALYs率在不同SDI国家中处于较低水平。此外，归因于高体质量指数的哮喘DALYs率呈升高趋势，1~4岁组年度平均变化百分比(AAPC)为2.9%，其他年龄组AAPC均为4.2%;15~19岁组归因于职业性致喘物的DALYs率呈降低趋势，AAPC为-2.5%。结论中国儿童青少年哮喘疾病负担较低，有性别和年龄别差异，变化呈“降低—升高—降低”趋势。应重点关注男生和5~9岁儿童哮喘防治，加强对肥胖和职业性致喘物等危险因素的干预。
- 哮喘 /
- 回归分析 /
- 儿童 /
- 青少年
Abstract: Objective To explore trends in the asthma burden among Chinese children and adolescents 1-19 years old during 1990-2019. Methods Based on data from the 2019 Global Burden of Disease Study, joinpoint regression was used to analyze the dynamic changes in the gender-and age-specific asthma burden, and the asthma burden in China was compared with countries that have different socio-demographic indices(SDI). In addition, trends in asthma burden attributed to different risk factors were also investigated. Results The asthma burden decreased slightly from 1990 to 1996 [annual percent change (APC)=-1.7%], then rapidly decreased from 1996 to 2005 (APC=-5.7%). The age-standardized disability adjusted life years (DALYs) rate decreased from 158.55/100 000 to 88.59/100 000 in patients 1-19 years of age. From 2005 to 2017, the DALYs rate for asthma increased slowly, then rapidly. In 2017, the DALYs rate peaked at 176.18/100 000, then decreased to 126.79/100 000 in 2019. The burden of asthma in boys was higher than girls, and the DALYs rate for asthma in the group 5-9 years of age was higher than the remaining age groups. Furthermore, the age-standardized DALYs rate for asthma among Chinese children and adolescents was relatively low among countries with a different SDI. In addition, the DALYs rate attributed to high body mass index increased in all age groups in China. Specifically, the average APC (AAPC) was 2.9% in group 1-4 years of age and the AAPC was 4.2% in the remaining age groups. The DALYs rate attributed to occupational asthmagens in the group 15-19 years of age decreased from 1990 to 2019 and the AAPC was -2.5%. Conclusion The asthma burden was relatively low among Chinese children and adolescents, and there were gender and age differences. The gender-and age-specific DALYs rate for asthma had a tendency to decrease, increase, then decrease. More attention should be paid to boys and the group 5-9 years of age, and strengthen the intervention of obesity and occupational asthmagens.
- Asthma /
- Regression analysis /
- Child /
- Adolescent
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

HTML全文

图 1 1990—2019年不同SDI水平地区儿童青少年年龄标化哮喘DALYs率变化趋势

Figure 1. Trends in age-standardized DALYs rate of asthma in the children and adolescents from 1990 to 2019 categorized by socio-demographic index

下载: 全尺寸图片幻灯片

图 2 1990—2019年不同SDI水平地区儿童青少年年龄标化哮喘YLDs率变化趋势

Figure 2. Trends in age-standardized YLDs rate of asthma in the children and adolescents from 1990 to 2019 categorized by socio-demographic index

下载: 全尺寸图片幻灯片

图 3 1990—2019年不同SDI水平地区儿童青少年年龄标化哮喘YLLs率变化趋势

Figure 3. Trends in age-standardized YLLs rate of asthma in the children and adolescents from 1990 to 2019 categorized by socio-demographic index

下载: 全尺寸图片幻灯片

表 1 2019年中国不同年龄和性别儿童青少年哮喘疾病负担/10^-5

Table 1. Burden of asthma among Chinese children and adolescents in 2019 categorized by age and sex/100 000

性别	年龄/岁	DALYs率	YLDs率	YLLs率
男	1~4	143.94(72.06~265.92)	140.87(69.16~262.78)	3.07(1.88~4.94)
	5~9	204.74(104.50~376.61)	202.81(102.82~373.86)	1.93(1.35~2.76)
	10~14	134.18(72.17~232.28)	132.05(70.24~230.03)	2.13(1.58~2.96)
	15~19	85.39(45.43~147.47)	82.88(42.49~144.88)	2.51(1.81~3.63)
	1~19	142.82(142.22~143.42)^a	140.44(139.85~141.04)^a	2.38(2.30~2.46)^a
女	1~4	109.74(55.11~200.48)	107.26(52.02~198.21)	2.49(1.71~3.63)
	5~9	146.85(73.29~271.67)	145.65(72.32~270.56)	1.20(0.92~1.70)
	10~14	100.69(52.31~176.66)	99.31(51.30~175.27)	1.38(1.05~1.92)
	15~19	72.90(38.80~125.99)	70.47(35.66~123.87)	2.43(1.72~3.39)
	1~19	107.97(107.40~108.53)^a	106.13(105.57~106.60)^a	1.84(1.77~1.91)^a
合计	1~4	128.15(64.07~235.68)	125.35(61.92~232.81)	2.80(1.90~4.06)
	5~9	178.14(90.50~329.02)	176.55(89.03~327.38)	1.59(1.20~2.21)
	10~14	118.86(63.16~205.74)	117.07(61.28~204.28)	1.79(1.41~2.43)
	15~19	79.56(42.34~137.71)	77.09(39.38~135.54)	2.47(1.95~3.35)
	1~19	126.79(126.37~127.20)	124.66(124.24~125.07)	2.13(2.08, 2.18)
注：()内数字为95%UI，a表示在男生和女生间异质性P < 0.01。

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