甘肃省0~6岁儿童血清25-羟基维生素D水平

黄蕾; 南楠; 刘爱萍; 杨晓芳; 李灵; 朱瑛

doi:10.16835/j.cnki.1000-9817.2021.12.011

甘肃省0~6岁儿童血清25-羟基维生素D水平

doi: 10.16835/j.cnki.1000-9817.2021.12.011

黄蕾¹,
南楠¹,
刘爱萍¹,
杨晓芳²,
李灵³,
朱瑛^1, ,

1.
甘肃省妇幼保健院儿保科，兰州 730050
2.
张掖市甘州区妇幼保健院儿保科
3.
酒泉市肃州区妇幼保健院儿保科

基金项目:

甘肃省卫生行业科研计划项目 GSWSKY-2019-22

详细信息

作者简介:
黄蕾(1984-)，女，甘肃兰州人，硕士，副主任医师，主要研究方向为儿童生长发育

通讯作者:
朱瑛，E-mail：1441751052@qq.com

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中图分类号: R151 R153.2 R446
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- 被引次数: 0
出版历程
- 收稿日期: 2021-07-21
- 修回日期: 2021-09-23
- 网络出版日期: 2021-12-23
- 刊出日期: 2021-12-25

Analysis of serum 25-hydroxyvitamin D levels in children aged 0-6 years in Gansu Province

1.
Child Health Care Section, Gansu Hospital of Maternal and Child Care, Lanzhou(730050), China

摘要

摘要: 目的分析甘肃省0~6岁儿童血清25-(OH)D的营养状况，分析其年龄、季节特点以及与体格发育间的关联，为儿童及时合理补充维生素D提供科学依据。方法采用分层随机整群抽样方法收集2019年1月至2020年12月甘肃省内兰州市、定西市、临夏州、甘南州、张掖市、酒泉市进行健康检查的0~6岁儿童共9 790名。采集末梢血1 mL，使用酶联免疫法检测血清25-(OH)D浓度。根据身长(高)别体重分为超重组及体重正常组。结果 0~6岁儿童血清25-(OH)D水平为81.31(63.14，95.86)nmol/L，维生素D缺乏和不足的检出率为45.11%。4~6岁组儿童血清维生素D水平明显低于 < 1岁婴儿及1~ < 4岁儿童，4~6岁组儿童维生素D缺乏及不足的检出率最高(χ²=83.67，P < 0.05)。冬季发生维生素D缺乏及不足的比例最高(55.82%)(χ²=194.12，P < 0.01)。秋季超重儿童维生素D缺乏的检出率较高(19.83%)(P < 0.01)。结论儿童维生素D水平与年龄、季节及体格发育水平均有关联，< 1及 > 4岁组应是维生素D重点监测的年龄段，冬季应是维生素D监测的重要季节，对于超重儿童秋季应作为预防维生素D缺乏的重点时期。
- 血清 /
- 维生素D /
- 营养状况 /
- 儿童
Abstract: Objective To analyze the status of serum 25-hydroxyvitamin D in children aged 0-6 years in Gansu Province, and to analyze the relationships between 25-(OH)D and age, seasonal characteristics and physical development, so as to provide a scientific reference for supplementing vitamin D for children in due time. Methods Stratified random cluster sampling method was used to select a total of 9 790 children aged 0-6 years from 6 cities and prefectures maternity and child health institutions in Gansu Province for health examination from January 2019 to December 2020. Serum 25-(OH)D concentration from 1 mL peripheral blood was tested by enzyme-linked immunoassay. Subjects were classified into overweight and normal figure groups based on weight for height. Results the serum 25-(OH)D level M(P₂₅, P₇₅) of the children aged 0-6 was 81.31(63.14, 95.86)nmol/L. The detection rate of 25-(OH)D deficiency and insufficiency was 45.11%. The serum 25-(OH)D level of children 4-6 years old was significantly lower than that of infants < 1 year old and children 1- < 4 years old, and the detection rate of 25-(OH)D deficiency and insufficiency was highest among 4-6 years old(χ²=83.67, P < 0.05). In winter the proportion of 25-(OH)D insufficiency and deficiency was highest (55.82%) (χ²=194.12, P < 0.01). For overweight children, the abnormal rate of 25-(OH)D (19.83%) was significantly higher in autumn (P < 0.01). Conclusion Children's vitamin D levels were associated with age, season and physical development. Vitamin D surveillance should be focused on ages less than 1 year old and above 4 years old, winter should be an important season. For overweight children, autumn should be the focus period for vitamin D deficiency prevention.
- Serum /
- Vitamin D /
- Nutritional status /
- Child
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表 1 不同性别及年龄组儿童血清25-(OH)D水平分布比较

Table 1. Distribution of serum 25-(OH)D levels in children of different sexes and age groups

组别	选项	人数	缺乏	不足	充足	χ²值	P值
性别	男	5 434	506(9.31)	1 909(35.13)	3 019(55.56)	3.26	0.20
	女	4 356	445(10.22)	1 556(35.72)	2 355(54.06)
年龄/岁	＜1	4 216	424(10.06)	1 462(34.68)	2 330(55.27)	83.67	＜0.01
	1~＜2	2 006	196(9.77)	662(33.00)	1 148(57.23)
	2~＜3	1 511	131(8.67)	545(36.07)	835(55.26)
	3~＜4	1 078	92(8.53)	340(31.54)	646(59.93)
	4~6	979	108(11.03)	456(46.58)	415(42.39)
注：()内数字为构成比/%。

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表 2 不同季节超重与正常体重儿童血清25-(OH)D水平分布比较

Table 2. Distribution of serum 25-(OH)D in overweight and normal figure children in different seasons

季节	分组	人数	缺乏	不足	充足	χ²值	P值
春	正常	2 432	147(6.04)	751(30.88)	1 534(63.08)	5.79	0.06
	超重	152	5(3.29)	37(24.34)	110(72.37)
夏	正常	2 270	232(10.22)	789(34.76)	1 249(55.02)	1.87	0.39
	超重	90	10(11.11)	25(27.78)	55(61.11)
秋	正常	2 825	246(8.71)	1 073(37.98)	1 506(53.31)	18.83	＜0.01
	超重	116	23(19.83)	31(26.72)	62(53.45)
冬	正常	1 527	213(13.95)	643(42.11)	671(43.94)	1.21	0.55
	超重	67	8(11.94)	25(37.31)	34(50.75)
注：()内数字为构成比/%。

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参考文献(17)

[1]	BRETT N R, LAVERY P, AGELLON S, et al. Dietary vitamin D dose-response in healthy children 2 to 8 y of age: a 12-wk randomized controlled trial using fortified foods[J]. Am J Clin Nutr, 2016, 103(1): 144-152. doi: 10.3945/ajcn.115.115956
[2]	CHEN Z, LYU X, HU W, et al. Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou[J]. Front Public Health, 2021, 9: 675403. doi: 10.3389/fpubh.2021.675403
[3]	张浩, 董洋洋, 马萍, 等. 中国儿童青少年维生素D营养状况的Meta分析[J]. 中国循证医学杂志, 2021, 21(3): 284-289. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXZ202103006.htm ZHANG H, DONG Y Y, MA P, et al. Vitamin D nutritional status in Chinese children and adolescents: a meta-analysis[J]. Chin J Evid-Based Med, 2021, 21(3): 284-289. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXZ202103006.htm
[4]	GANJI V, MARTINEAU B, VAN FLEIT W E. Association of serum vitamin D concentrations with dietary patterns in children and adolescents[J]. Nutr J, 2018, 17(1): 58. doi: 10.1186/s12937-018-0365-7
[5]	原晨晨, 薛琨, 郭红卫. 全球儿童超重肥胖的流行现状和影响因素[J]. 卫生研究, 2020, 49(3): 506-510. https://www.cnki.com.cn/Article/CJFDTOTAL-WSYJ202003034.htm YUAN C C, XUE K, GUO H W. The prevalence of overweight and obesity among children in China[J]. J Hyg Res, 2020, 49(3): 506-510. https://www.cnki.com.cn/Article/CJFDTOTAL-WSYJ202003034.htm
[6]	NIMITPHONG H, PARK E, LEE M J. Vitamin D regulation of adipogenesis and adipose tissue functions[J]. Nutr Res Pract, 2020, 14(6): 553-567. doi: 10.4162/nrp.2020.14.6.553
[7]	陈荣华, 赵正言, 刘湘云. 儿童保健学[M]. 5版. 南京: 江苏凤凰科学技术出版社, 2018: 273. CHEN R H, ZHAO Z Y, LIU X Y. Child Health[M]. 5 ed. Nanjing: Jiangsu Phoenix Science and Technology Press, 2018: 273.
[8]	张萍萍, 黎雅婷, 李晓峰, 等. 0~14岁儿童25-羟维生素D水平调查与分析[J]. 中国儿童保健杂志, 2014, 22(8): 856-859. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201408024.htm ZHANG P P, LI Y T, LI X F, et al. Analysis of 25-hydroxy vitamin D levels in children aged 0 to 14 years old in Guangzhou city[J]. Chin J Child Health Care, 2014, 22(8): 856-859. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201408024.htm
[9]	赵艳, 秦锐, 马向华. 江苏省0~5岁儿童维生素D营养状况研究[J]. 中国儿童保健杂志, 2020, 28(11): 1214-1218. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO202011011.htm ZHAO Y, QIN R, MA X H. Vitamin D status among 0-5 years old children in Jiangsu province of China[J]. Chin J Child Health Care, 2020, 28(11): 1214-1218. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO202011011.htm
[10]	王慧燕, 温怀凯, 王玲莉, 等. 6 651例0~16岁儿童维生素D营养状况调查分析[J]. 中国卫生检验杂志, 2016, 26(9): 1325-1327. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ201609042.htm WANG H Y, WEN H K, WANG L L, et al. Investigation and analysis of vitamin D nutritional status in 6651 children at 0-16 years old[J]. Chin J Health Laborat Sci, 2016, 26(9): 1325-1327. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ201609042.htm
[11]	陶秀玲, 王婉平, 张涵斌, 等. 台州市黄岩区0~14岁儿童血清25-羟基维生素D水平[J]. 中国学校卫生, 2017, 38(12): 1875-1877. doi: 10.16835/j.cnki.1000-9817.2017.12.033 TAO X L, WANG W P, ZHANG H B, et al. Serum 25-hydroxyvitamin D levels in children aged 0-14 years in Huangyan District Taizhou City[J]. Chin J Sch Health, 2017, 38(12): 1875-1877. doi: 10.16835/j.cnki.1000-9817.2017.12.033
[12]	邓红岩, 蔡婧晔, 侯江婷, 等. 张家港市2 942例婴幼儿25-羟基维生素D水平现状分析[J]. 现代预防医学, 2018, 45(16): 2954-2957. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201816017.htm DENG H Y, CAI J Y, HOU J T, et al. Analysis of the present situation of 25-hydroxyvitamin D in 2 942 infants in Zhangjiagang City[J]. Mod Prev Med, 2018, 45(16): 2954-2957. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201816017.htm
[13]	袁静, 祝明, 赵旭生, 等. 2416名0~14岁健康儿童血清25-羟基维生素D水平分析[J]. 中国实用儿科杂志, 2018, 33(2): 145-147. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201802018.htm YUAN J, ZHU M, ZHAO X S, et al. Analysis of the serum 25-hydroxyvitamin D level in 2416 children aged from 0 to 14 years old[J]. Chin J Practic Pediatr, 2018, 33(2): 145-147. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201802018.htm
[14]	刘琰, 潘子奇, 王美辰, 等. 中国八地区学龄前儿童维生素D摄入情况研究[J]. 营养学报, 2016, 38(6): 541-545. https://www.cnki.com.cn/Article/CJFDTOTAL-YYXX201606010.htm LIU Y, PAN Z Q, WANG M C, et al. Nvestigation on vitamin D intake among preschoolers from eight areas in China[J]. Chin J Nutr, 2016, 38(6): 541-545. https://www.cnki.com.cn/Article/CJFDTOTAL-YYXX201606010.htm
[15]	RODRÍGUEZ-RODRÍGUEZ E, NAVIA-LOMBÁN B, LÓ PEZ-SOBALER A M, et al. Associations between abdominal fat and body mass index on vitamin D status in a group of Spanish school children[J]. Eur J Clin Nutr, 2010, 64(5): 461-467. doi: 10.1038/ejcn.2010.26
[16]	牛晓丽, 韩百惠, 蒋丽佳. 银川市7~18岁儿童维生素D营养状况与体质量指数的关系[J]. 中国学校卫生, 2019, 40(2): 289-191. doi: 10.16835/j.cnki.1000-9817.2019.02.037 NIU X L, HAN B H, JIANG L J. The relationship between vitamin D nutrition status and body mass index in children aged 7-18 years[J]. Chin J Sch Health, 2019, 40(2): 289-191. doi: 10.16835/j.cnki.1000-9817.2019.02.037
[17]	李军石. 25-羟维生素D与小儿单纯性肥胖的关系探讨[J]. 中国实用医药, 2015, 10(5): 128-129. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA201505089.htm LI J S. Study on the relationship between 25-hydroxyvitamin D and simple obesity in children[J]. Chin J Appl Med, 2015, 10(5): 128-129. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA201505089.htm