12周有氧运动对习惯久坐大学生微循环功能的影响

周术锋; 肖哲; 朱欢; 周慧敏; 杨梅; 彭永; 刘晓丽; 胡庆华

doi:10.16835/j.cnki.1000-9817.2021.09.013

12周有氧运动对习惯久坐大学生微循环功能的影响

doi: 10.16835/j.cnki.1000-9817.2021.09.013

周术锋¹,
肖哲¹,
朱欢^1, ,,
周慧敏²,
杨梅¹,
彭永¹,
刘晓丽¹,
胡庆华¹

1.
湖北民族大学体育学院/运动科学研究中心, 恩施 445000
2.
湖北民族大学科技学院音乐与体育学院

基金项目:

2020年湖北省教育厅科学研究计划青年项目 Q20201905

2020年湖北省高等学校省级教学研究项目 2020550

2021年湖北民族大学研究生教育创新项目 MYG2021002

2021年湖北民族大学高水平科研成果校内培育项目 PY21009

详细信息

作者简介:
周术锋(1992-), 男, 湖北恩施人, 博士, 助教, 主要研究方向为运动健康促进

通讯作者:
朱欢, E-mail: 1207105091@qq.com

中图分类号: G 807 G 647.8 R 446
计量
- 文章访问数: 889
- HTML全文浏览量: 404
- PDF下载量: 45
- 被引次数: 0
出版历程
- 收稿日期: 2021-04-12
- 修回日期: 2021-06-22
- 网络出版日期: 2021-09-24
- 刊出日期: 2021-09-24

Effect of 12-week aerobic exercise on microcirculation function of sedentary college students

1.
Institute of Physical Education/Sports Science Research Centre, Hubei Minzu University, Enshi(445000), Hubei Province, China

摘要

摘要: 目的探讨不同剂量的有氧运动对习惯久坐大学生微循环功能的影响，为指导大学生科学体育干预性行为提供参考。方法招募湖北民族大学在校生69名，分成运动A组、运动B组和对照组，每组各23人(男生12名，女生11名)。运动组进行12周有氧运动干预，其中A组每周运动1~2次，B组每周运动≥3次，对照组不进行任何系统性的体育运动。分别在试验前、试验后对3组受试者微血管反应、经皮氧分压(TcpO₂)、一氧化氮(NO)、一氧化氮合酶(NOS)及内皮素-1(ET-1)进行测试。结果试验后，微血管反应性呈现出组别和时间交互作用(P=0.00)，其中运动B组大于对照组及运动A组(P<0.01)，运动A组与对照组差异无统计学意义(P>0.05)，但经皮氧分压不具有时间与组别的交互作用(P=0.53)；NO(F=6.32)，NOS(F=7.91)具有组别和时间交互作用，其中运动B组大于对照组及运动A组(P<0.01)，运动A组与对照组差异无统计学意义(P>0.05)。结论有氧运动影响身体微血管反应及内源性NO水平，持续12周、每周≥3次的有氧运动能通过促进内源性NO的生成提高久坐大学生微血管反应性，但每周1~2次的有氧运动对微血管反应性无显著影响。
- 运动活动 /
- 闲暇活动 /
- 微循环 /
- 健康促进 /
- 干预性研究 /
- 学生
Abstract: Objective To investigate the effects of different doses of aerobic exercise on the microvascular function of habitually sedentary college students. Methods A total of 69 students from Hubei Minzu University were recruited and divided into sports group A, sports group B and control group, with 23 students in each group (12 boys and 11 girls). The exercise group received 12 weeks of aerobic exercise intervention, in which group A exercised 1-2 times a week, group B exercised≥3 times a week, and the control group did not carry out any systematic sports. Microvascular response, Transcutaneous partial pressure of oxygen(TcpO₂), Nitric oxide, Nitric oxide synthase (NOS) and En-dothelin-1 (ET-1) were measured before and after the test. Results After the test, the microvascular reactivity showed group and time interaction(P<0.01), in which exercise group B was greater than that of control group and exercise group A (P<0.01). There was no significant difference between exercise group A and control group (P>0.05), but the percutaneous partial pressure of oxygen (P=0.53) had no time interaction with other groups; NO(F=6.32) and NOS(F=7.91) had group and time interaction, in which exercise group B was greater than control group and exercise group A (P<0.01), and there was no significant difference between exercise group A and control group (P>0.05). Conclusion There is a "dose-effect" relationship between aerobic exercise and microcirculatory blood perfusion and endogenous NO. Continuous aerobic exercise ≥3 times a week for 12 weeks improved microcirculatory blood perfusion and promoted endogenous NO production in sedentary college students, but doing aerobic exercise for 1-2 times a week had no significant effect on microcirculatory blood perfusion and endogenous NO.
- Motor activity /
- Leisure activities /
- Microcirculation /
- Health promotion /
- Intervention studies /
- Students

HTML全文

表 1 不同组别受试者试验前后测试微循环反应性及TcpO₂比较(x ±s)

Table 1. Comparison of microcirculation reactivity and TcpO₂ of different groups of subjects before and after the experiment(x ±s)

组别	试验前后	人数	统计值	皮温/℃		MBP		CMBC		AVBC/℃		TcpO₂
组别	试验前后	人数	统计值	基础值	加热值	基础值	加热值	基础值	加热值	基础值	加热值	TcpO₂
对照组	试验前	23		31.9±1.2	44.1±0.2	7.9±1.8	92.1±24.7	79.6±25.4	237.2±56.4	9.9±1.8	38.8±8.7	62.7±7.6
	试验后	23		31.7±0.6	44.1±0.2	8.5±2.1	93.5±27.1	81.2±30.7	239.5±59.4	9.7±1.3	39.1±9.2	65.7±8.6
			t值	0.74	0.01	-1.46	-0.97	-0.85	-0.89	0.04	-1.08	-1.76
			P值	0.48	0.63	0.17	0.40	0.36	0.41	0.67	0.17	0.19
运动A组	试验前	23		31.3±0.8	44.2±0.3	8.1±1.4	93.4±30.9	82.8±28.3	240.6±60.2	10.3±2.6	38.8±10.1	63.5±8.1
	试验后	23		31.6±1.1	43.9±0.6	8.7±2.4	93.7±29.2	76.9±21.4	241.6±60.9	9.3±0.8	38.7±9.4	64.9±9.1
			t值	-0.04	-0.06	-1.40	-0.07	3.47	-1.18	0.86	0.07	-0.96
			P值	0.52	0.35	0.22	0.63	0.06	0.31	0.09	0.72	0.34
运动B组	试验前	23		31.5±1.1	43.8±0.4	8.0±2.0	90.8±20.6	78.9±23.4	239.1±58.8	10.1±2.1	37.9±9.1	60.4±7.2
	试验后	23		31.4±0.9	44.1±0.5	7.5±1.5	98.7±30.2	80.2±19.6	260.3±68.7	9.3±1.1	37.9±8.6	62.6±8.5
			t值	0.28	-0.22	1.55	-15.27	-2.04	-19.38	0.09	0.03	-0.88
			P值	0.48	0.47	0.12	0.02	0.09	0.01	0.54	0.77	0.42

下载: 导出CSV

表 2 不同组别受试者试验前后微循环反应性增加率/%

Table 2. Microcirculation reactivity increase rate of subjects in different groups before and after the experiment/%

组别	试验前后	人数	统计值	皮温	MBP	CMBC	AVBC
对照组	试验前	23		40.1	997.5	176.3	286.9
	试验后	23		39.4	989.0	186.4	291.4
			t值	1.02	2.03	2.22	1.19
			P值	0.55	0.06	0.06	0.13
运动A组	试验前	23		41.2	993.5	183.5	281.4
	试验后	23		38.9	977.0	190.4	294.6
			t值	1.16	2.20	1.84	2.32
			P值	0.22	0.05	0.02	0.06
运动B组	试验前	23		39.0	1 030.1	184.2	279.3
	试验后	23		40.7	1 216.2	224.0	307.0
			t值	1.10	16.53	18.57	10.86
			P值	0.37	0.02	0.01	0.02

下载: 导出CSV

表 3 不同组别受试者试验前后NO、NOS及ET-1比较(x ±s)

Table 3. Changes of NO、NOS and ET-1 in three groups before and after the experiment (x ±s)

组别	试验前后	人数	统计值	NO/ (μmol·L^-1)	TNOS/ (U·mL^-1)	eNOS/ (U·mL^-1)	iNOS/ (U·mL^-1)	ET-1/ (pg·mL^-1)
对照组	试验前	23		51.0±4.0	38.6±1.9	12.7±3.8	19.3±2.9	13.5±2.3
	试验后	23		50.9±3.8	37.8±2.0	13.9±4.5	19.8±3.2	13.9±2.6
			t值	0.01	0.02	0.70	0.09	0.00
			P值	0.76	0.63	0.34	0.53	0.82
运动A组	试验前	23		52.4±4.6	38.1±1.8	13.4±2.8	19.5±2.8	13.1±2.5
	试验后	23		53.7±5.7	39.2±1.8	14.1±4.3	21.1±3.5	14.2±2.1
			t值	0.09	1.17	1.05	1.37	1.23
			P值	0.17	0.10	0.09	0.08	0.07
运动B组	试验前	23		51.9±5.1	37.4±2.0	13.1±5.7	20.4±3.1	13.4±2.5
	试验后	23		55.6±5.2	41.0±2.1	15.5±3.6	20.1±3.3	14.8±2.3
			t值	9.73	12.02	8.91	0.04	0.87
			P值	0.02	0.01	0.02	0.63	0.28

下载: 导出CSV

参考文献(23)

[1]	JUSTIN D, GABRIE L F, YAN H M, et al. Microvascular endothelial dysfunction in sedenary, obese humans is mediated by NADPH oxidase influence of exercise training[J]. Arter Thr Vasc Biol, 2016, 36(12): 2412-2420. doi: 10.1161/ATVBAHA.116.308339
[2]	韩冬柏, 刘晓宇, 李娜, 等. 微循环障碍与高血压关系的研究进展[J]. 实用心脑肺血管病杂志, 2020, 28(5): 112-115, 120. doi: 10.3969/j.issn.1008-5971.2020.05.022 HAN D B, LIU X Y, LI N, et al. Research progress on the relationship between microcirculatory disorders and hypertension[J]. Pract J Cardiac Cerebr Pneum Vascul Dis, 2020, 28(5): 112-115, 120. doi: 10.3969/j.issn.1008-5971.2020.05.022
[3]	OKADA H, TANAKA M, YASUDA T, et al. Decreased microcirculatory function measured by perfusion index is a novel indicator of diabetic kidney disease in patients with t-ype 2 diabetes[J]. J Diab Invest, 2020, 11(3): 681-687. doi: 10.1111/jdi.13193
[4]	HODGES G J, SHARP L, STEPHENSION C, et al. The effect of 48 weeks of aerobic exercise training on cutaneous vasodilator function in post-menopausal females[J]. Eur J Appl Physiol, 2010, 108(6): 1259-1267. doi: 10.1007/s00421-009-1330-0
[5]	TEW G A, GEORGE K P, CAB N T, et al. Endurance exercise training enhances cutane-ous microvascular reactivity in post-menopausal women[J]. Micr Res, 2011, 83(2): 223-228.
[6]	朱欢, 胡庆华, 彭爱萍, 等. 长期太极拳运动对中老年人膝关节皮肤微血管反应性、经皮氧分压的影响[J]. 中国应用生理学杂志, 2020, 36(4): 321-323, 384. ZHU H, HU Q H, PENG A P, et al. Effects of long-term Taijiquan exercise on skin microvascular reactivity and transcutaneous oxygen partial pressure of knee joint in middle-aged and elderly people[J]. Chin J Appl Physiol, 2020, 36(4): 321-323, 384.
[7]	朱欢, 高炳宏. 有氧运动对人体微血管反应性的作用及机制研究进展[J]. 生命科学, 2020, 32(8): 97-105. ZHU H, GAO B H. Research progress in effects and mechanisms of aerobic exercise on human microvascular reactivity[J]. Chin Bull Life Sci, 2020, 32(8): 97-105.
[8]	张丽萍, 章岚. 递增负荷运动方案推算超重/肥胖青年男性FATmax有效性研究[J]. 中国体育科技, 2018, 54(3): 87-91, 145. ZHANG L P, ZHANG L. Study on fatmax of overweight and obese young men by incremental load Exercise[J]. Chin Sports Tech, 2018, 54(3): 87-91, 145.
[9]	朱欢, 高炳宏. 微血管反应性在耐力性运动员训练中的应用[J]. 中国运动医学杂志, 2019, 38(10): 907-914 doi: 10.3969/j.issn.1000-6710.2019.10.013 ZHU H, GAO B H. Application of microvascular reactivity in training of endurance athletes[J]. Chin J Sports Med, 2019, 38(10): 907-914 doi: 10.3969/j.issn.1000-6710.2019.10.013
[10]	朱欢, 高炳宏. 不同性别赛艇运动员肱二头肌微循环血流灌注量的比较[J]. 中国应用生理学杂志, 2016, 32(3): 277-278, 288. ZHU H, GAO B H. Comparison of microcirculation blood flow perfusion of biceps brachii in rowers of different genders[J]. Chin J App Physiol, 2016, 32(3): 277-278, 288.
[11]	MICHAEL M, 任倩(译). 每日久坐导致2型糖尿病风险升高22%[J]. 中华全科医师杂志, 2016, 15(12): 957. MICHAEL M, REN Q. The risk of type 2 diabetes mellitus increased by 22% due to daily sedentary time[J]. Chin J Gen Pract, 2017, 23(2): 957.
[12]	NAYLOR L H, DAVIS E A, KALIC R J, et al. Exercise training improvesvascular function in adolescents with type 2 diabetes[J]. Phys Rep, 2016, 4(4): e12713-e12724. doi: 10.14814/phy2.12713
[13]	PASQUALINI L, SCHILLACI G, INNOCENTE S, et al. Lifestyle intervention improves micov-as cular reactivity and increases serum adiponectin in overweight hypertensive patients[J]. Nutr Metab Cardiovas, 2010, 20(2): 87-92. doi: 10.1016/j.numecd.2009.03.002
[14]	MORAES R D, BAVEL D V, BRITO M D, et al. Effects of non-supervised low intensity aerobic excise training on themicrovascular endothelial function ofpatients with type 1 diabetes: anonpharacological interventional study[J]. BMC Card Dis, 2016, 16(23): 23-31.
[15]	BORGES J P, NASCIMENT A R, LOPES G O, et al. The impact of exercise frequency upon microvascular endothelium function and oxidative stress among patients with coronary artery disease[J]. Clin Physiol Funct Imag, 2018, 38(5): 840-846. doi: 10.1111/cpf.12492
[16]	MACHADO M V, VIEIRA A B, DA CONCEIÇÃO F, et al. Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome[J]. Exp Physiol, 2017, 102(12): 1716-1728. doi: 10.1113/EP086416
[17]	PANISSA VALÉRIA L G, FUKUDA D H, CALDEIRA R S, et al. Is oxygen uptake measurement enough to estimate energy expenditure during high-intensity intermittent exercise? Quantification of anaerobic contribution by different methods[J]. Fron Phys, 2018, 9: 868-875.
[18]	LI M, WANG N, ZHANG J. MicroRNA-29a-3 pattenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytes[J]. Gene, 2016, 585(1): 44-50. doi: 10.1016/j.gene.2016.03.015
[19]	CORREIA-COSTA L, MORATO M, SOUSA T, et al. Urinary fibrogenic cytokines ET-1 and TGF-β1 are associated with urinary angiotensinogen levels in obese children[J]. Pediatr Nephrol, 2016, 31(3): 455-464. doi: 10.1007/s00467-015-3232-1
[20]	刘蜜, 李玉珍, 宋丹丹, 等. 不同性别和年龄健康成年人足趾皮肤温度和血流灌注量的测定分析[J]. 微循环学杂志, 2012, 22(4): 39-41. LIU M, LI Y Z, SONG D D, et al. Measurement and analysis of toe skin temperature and blood flow perfusion in healthy adults of different gender and age[J]. Chin J Microcircul, 2012, 22(4): 39-41.
[21]	王艺璇, 蔡军. 剪切力和拉伸应力对血管内皮细胞的影响[J]. 中国医学前沿杂志(电子版), 2012, 4(8): 38-41. doi: 10.3969/j.issn.1674-7372.2012.08.009 WANG Y Y, CAI J. Effects of shear stress and tensile stress on vascular endothelial cells[J]. Chin J Front Med Sci(Electron Ver), 2012, 4(8): 38-41. doi: 10.3969/j.issn.1674-7372.2012.08.009
[22]	DOW C A, STAUFFER B L, BRUNJES D L. Regular aerobic exercise reduces endothelin 1 mediated vasoconstrictor tone in overweight and obese adults[J]. Exper Phys, 2017, 102(9): 1133-1142. doi: 10.1113/EP086454
[23]	罗琪. 有氧运动对大鼠血脂及血管内皮素和一氧化氮合酶的影响[D]. 苏州: 苏州大学, 2006. LUO Q. Effects of aerobic exercise on blood lipid, endothelin and nitric oxide synthase in rats[D]. Suzhou: Soochow University, 2006.