青春期女生尿液中大豆异黄酮代谢物与性发育的关系

章涵; 赵玉霞

doi:10.16835/j.cnki.1000-9817.2021.07.028

青春期女生尿液中大豆异黄酮代谢物与性发育的关系

doi: 10.16835/j.cnki.1000-9817.2021.07.028

章涵,
赵玉霞^,

信阳职业技术学院医学院, 河南 464000

基金项目:

河南省高等学校重点科研项目资助计划 21A330005

详细信息

作者简介:
章涵(1978-)，男，河南淮滨人，硕士，副教授，主要从事青少年卫生教研工作

通讯作者:
赵玉霞，E-mail：zhaoyuxia888@126.com

中图分类号: R446 R173
计量
- 文章访问数: 630
- HTML全文浏览量: 388
- PDF下载量: 29
- 被引次数: 0
出版历程
- 收稿日期: 2021-01-04
- 修回日期: 2021-04-13
- 网络出版日期: 2021-07-23
- 刊出日期: 2021-07-25

Relationship between soy isoflavone metabolites in urine and sexual development of adolescent girls

ZHANG Han,
ZHAO Yuxia^,

Medical School, Xinyang Vocational and Technical College, Xinyang (464000), Henan Province, China

摘要

摘要: 目的探讨尿液中大豆异黄酮代谢物与青春期女生性发育的关系, 为女生青春期发育影响因素研究提供参考依据。方法在信阳市1所小学随机选择符合纳入标准的50名五年级女生为研究对象, 进行性发育评价及尿液中大豆异黄酮代谢物的测定。尿液中大豆异黄酮代谢物的测定运用超高速液相色谱-串联质谱分析法(UPLC-MS/MS)。结果不同性发育组女生(发育提前、发育正常和发育延迟)的染料木黄酮水平差异有统计学意义(F=3.53, P < 0.05), 发育提前组尿液染料木黄酮水平较高; 已来潮组和未来潮组染料木黄酮水平差异有统计学意义(t=2.16, P < 0.05), 已来潮组尿液染料木黄酮水平较高。结论尿液染料木黄酮水平高可能与青春期女生性发育提前有关。
- 异黄酮类 /
- 青春期 /
- 性发育 /
- 生长和发育 /
- 学生 /
- 女(雌)性
Abstract: Objective To explore the relationship between urinary soybean isoflavone metabolites and sexual development of adolescent girls. Methods Fifty girls of grade 5 from one primary school in Xingang City who met the inclusion criteria were selected. Sexual characteristic development was assessed and soybean isoflavone metabolites in urine was tested by ultra-high speed liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Results Levels of dye xylinone in girls with different stages of sexual development (advanced, normal, and delayed groups) varied significantly (F=3.53, P < 0.05), highest in advanced group. Urinary genistein was significantly higher in menarche group than that of non-menarche group (t=2.16, P < 0.05). Urinary genistein may be associated with early sexual development among adolescent girls. Conclusion High level of urine genistein may be related to the early sexual development of adolescent girls.
- Isoflavones /
- Puberty /
- Sexual development /
- Growth and development /
- Students /
- Female

HTML全文

表 1 不同组别女生大豆异黄酮代谢物水平比较(x±s，μmol·mol^-1)

Table 1. Comparison of soybean isoflavone metabolites levels in different pubertal development groups of girls (x±s, μmol·mol^-1)

组别	选项	人数	统计值	染料木黄酮	黄豆苷元
性发育	提前	8		186.7±24.1	315.6±33.4
	正常	35		171.8±22.8	308.4±31.1
	延迟	7		155.3±21.6	305.8±31.3
			F值	3.53	0.22
			P值	< 0.05	> 0.05
月经初潮	已来潮	6		213.4±22.5	311.4±32.2
	未来潮	44		166.3±21.7	308.9±31.9
			t值	2.16	0.08
			P值	< 0.05	> 0.05

下载: 导出CSV

参考文献(16)

[1]	D'ALOISIO A A, SANDLER D P. Prenatal and infant exposures and age at menarche[J]. Epidemiology, 2013, 24(2): 277-284. doi: 10.1097/EDE.0b013e31828062b7
[2]	MERVISH N A, GARDINER E W, GALVEZ M P, et al. Dietary flavonol intake is associated with age of puberty in a longitudinal cohort of girls[J]. Nutr Res, 2013, 33(7): 534-542. doi: 10.1016/j.nutres.2013.04.005
[3]	KIM J, KIM S, HUH K, et al. High serum isoflavone concentrations are associated with the risk of precocious puberty in Korean girls[J]. Clin Endocrinol (Oxf), 2011, 75(6): 831-835. doi: 10.1111/j.1365-2265.2011.04127.x
[4]	许媛媛, 孙丽, 陶兴永, 等. 富含植物雌激素食物摄入与女生青春期发育关系[J]. 中国公共卫生, 2018, 34(2): 210-213. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW201802012.htm XU Y Y, SUN L, TAO X Y, et al. on the relationship between phytoestrogen-rich food intake and adolescent development of girls[J]. Chin Public Health, 2018, 34(2): 210-213. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW201802012.htm
[5]	赵玉霞, 章涵, 郝艳红, 等. 膳食中植物雌激素摄入量与青春期女生性发育的关系[J]. 现代预防医学, 2020, 47(12): 2174-2177. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF202012020.htm ZHAO Y X, ZHANG H, HAO Y H, et al. Relationship between phytoestrogen intake and sexual development of adolescent girls[J]. Mod Prev Med, 2020, 47(12): 2174 -2177. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF202012020.htm
[6]	王秀伶, 王烨. 膳食中的植物雌激素、肠道菌群与人类健康[J]. 世界华人消化杂志, 2016, 24(35): 4660-4676. https://www.cnki.com.cn/Article/CJFDTOTAL-XXHB201635006.htm WANG X L, WANG Y. Phytoestrogens, intestinal flora and human health[J]. World Chin Digest Mag, 2016, 24(35): 4660-4676. https://www.cnki.com.cn/Article/CJFDTOTAL-XXHB201635006.htm
[7]	吴倩, 余静, 金念祖, 等. 大豆异黄酮摄入量估算值与尿液测定值相关性分析[J]. 现代预防医学, 2011, 38(2): 231-234. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201102014.htm WU Q, YU J, JIN N Z, et al. Analysis on the correlation between the estimation of isoflavone intake and urine[J]. Mod Prev Med, 2011, 38(2): 231-234. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201102014.htm
[8]	SUN Y, TAO F B, SU P Y, et al. National estimates of the pubertal milestones among urban and rural Chinese girls[J]. J Adolesc Health, 2012, 51(3): 279-284. doi: 10.1016/j.jadohealth.2011.12.019
[9]	KING R A, BURSILL D B. Plasma and urinary kinetics of the isofla-vones daidzein and genistein after a single soy meal in humans[J]. Am J Clin Nutr, 1998, 67: 867-872. doi: 10.1093/ajcn/67.5.867
[10]	王建, 王斌, 徐静, 等. 绝经后妇女尿中大豆异黄酮产物与骨质疏松相关性研究[J]. 营养学报, 2010, 32(6): 570-572 https://www.cnki.com.cn/Article/CJFDTOTAL-YYXX201006017.htm WANG J, WANG B, XU J, et al. Correlation between soybean isoflavone product and osteoporosis in urine of postmenopausal women[J]. J Nutr, 2010, 32(6): 570-572. https://www.cnki.com.cn/Article/CJFDTOTAL-YYXX201006017.htm
[11]	MEENA R, SUPRIYA C H, REDDY K P, et al. Altered spermatogenesis, steroidogenesis and suppressed fertility in adult male rats exposed to genistein, a non-steroidal phytoestrogen during embryonic development[J]. Food Chem Toxicol, 2017, 99: 70-77. http://smartsearch.nstl.gov.cn/paper_detail.html?id=5a7759be503090b4e31958df24955fcb
[12]	ATKINSON C, SKOR H E, FITZGIBBONS E D, et al. Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake[J]. Cancer Epidemiol Biomark Prev, 2002, 11(3): 253-260. http://www.researchgate.net/publication/303244559_Erratum_Overnight_urinary_isoflavone_excretion_in_a_population_of_women_living_in_the_United_States_and_its_relationship_to_isoflavone_intake_Cancer_Epidemiology_Biomarkers_and_Prevention_March_2002_1
[13]	MASKARINEC G, SINGH S, MENG L, et al. Dietary soy intake and urinary isoflavone excretion among women from a multiethnic population[J]. Cancer Epidemiol Biomark Prev, 1998, 7(7): 613 -619. http://www.ncbi.nlm.nih.gov/pubmed/9681530
[14]	LEE S A, WEN W Q, XIANG Y B, et al. Assessment of dietary isoflavone intake among middle-aged Chinesemen[J]. J Nutr, 2007, 137(4): 1011-1016. doi: 10.1093/jn/137.4.1011
[15]	HUANG M H, GAIL G H, MERVAT M M, et al. Assessing the accuracy of a food frequency questionnaire for estimating usual intake of phytoestrogens[J]. Nutr Cancer, 2000, 37(2): 145-154. doi: 10.1207/S15327914NC372_5
[16]	MARILYN T, TEMITOPE O, MINDY S, et al. Food frequency questionnaires and overnight urines are valid indicators of daidzein and genistein intake in U.S. women relative to multiple 24-h urine samples[J]. Nutr Cancer, 2008, 60(5): 619-626. doi: 10.1080/01635580801993751