青春期女生尿液中大豆异黄酮代谢物与性发育的关系

章涵; 赵玉霞

doi:10.16835/j.cnki.1000-9817.2021.07.028

青春期女生尿液中大豆异黄酮代谢物与性发育的关系

doi: 10.16835/j.cnki.1000-9817.2021.07.028

章涵,
赵玉霞^,

信阳职业技术学院医学院, 河南 464000

基金项目:

河南省高等学校重点科研项目资助计划 21A330005

详细信息

作者简介:
章涵(1978-)，男，河南淮滨人，硕士，副教授，主要从事青少年卫生教研工作

通讯作者:
赵玉霞，E-mail：zhaoyuxia888@126.com

中图分类号: R446 R173
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- 被引次数: 0
出版历程
- 收稿日期: 2021-01-04
- 修回日期: 2021-04-13
- 网络出版日期: 2021-07-23
- 刊出日期: 2021-07-25

Relationship between soy isoflavone metabolites in urine and sexual development of adolescent girls

ZHANG Han,
ZHAO Yuxia^,

Medical School, Xinyang Vocational and Technical College, Xinyang (464000), Henan Province, China

摘要

摘要: 目的探讨尿液中大豆异黄酮代谢物与青春期女生性发育的关系, 为女生青春期发育影响因素研究提供参考依据。方法在信阳市1所小学随机选择符合纳入标准的50名五年级女生为研究对象, 进行性发育评价及尿液中大豆异黄酮代谢物的测定。尿液中大豆异黄酮代谢物的测定运用超高速液相色谱-串联质谱分析法(UPLC-MS/MS)。结果不同性发育组女生(发育提前、发育正常和发育延迟)的染料木黄酮水平差异有统计学意义(F=3.53, P < 0.05), 发育提前组尿液染料木黄酮水平较高; 已来潮组和未来潮组染料木黄酮水平差异有统计学意义(t=2.16, P < 0.05), 已来潮组尿液染料木黄酮水平较高。结论尿液染料木黄酮水平高可能与青春期女生性发育提前有关。
- 异黄酮类 /
- 青春期 /
- 性发育 /
- 生长和发育 /
- 学生 /
- 女(雌)性
Abstract: Objective To explore the relationship between urinary soybean isoflavone metabolites and sexual development of adolescent girls. Methods Fifty girls of grade 5 from one primary school in Xingang City who met the inclusion criteria were selected. Sexual characteristic development was assessed and soybean isoflavone metabolites in urine was tested by ultra-high speed liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Results Levels of dye xylinone in girls with different stages of sexual development (advanced, normal, and delayed groups) varied significantly (F=3.53, P < 0.05), highest in advanced group. Urinary genistein was significantly higher in menarche group than that of non-menarche group (t=2.16, P < 0.05). Urinary genistein may be associated with early sexual development among adolescent girls. Conclusion High level of urine genistein may be related to the early sexual development of adolescent girls.
- Isoflavones /
- Puberty /
- Sexual development /
- Growth and development /
- Students /
- Female

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表 1 不同组别女生大豆异黄酮代谢物水平比较(x±s，μmol·mol^-1)

Table 1. Comparison of soybean isoflavone metabolites levels in different pubertal development groups of girls (x±s, μmol·mol^-1)

组别	选项	人数	统计值	染料木黄酮	黄豆苷元
性发育	提前	8		186.7±24.1	315.6±33.4
	正常	35		171.8±22.8	308.4±31.1
	延迟	7		155.3±21.6	305.8±31.3
			F值	3.53	0.22
			P值	< 0.05	> 0.05
月经初潮	已来潮	6		213.4±22.5	311.4±32.2
	未来潮	44		166.3±21.7	308.9±31.9
			t值	2.16	0.08
			P值	< 0.05	> 0.05

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