合肥城区进展性近视学龄儿童0.01%阿托品的疗效和安全性

王勇; 姜波

doi:10.16835/j.cnki.1000-9817.2021.02.004

合肥城区进展性近视学龄儿童0.01%阿托品的疗效和安全性

doi: 10.16835/j.cnki.1000-9817.2021.02.004

王勇,
姜波

安徽省第二人民医院眼科，合肥 230041

基金项目:

安徽省高校自然科学研究重点项目 KJ2019A1097

安徽省卫生计生委科研计划项 2018SEYL025

安徽省卫生计生委科研计划项 2018SEYL022

详细信息

作者简介:
王勇(1978-)，男，安徽合肥人，大学本科，副主任医师，主要研究方向为白内障及屈光

中图分类号: R 778.11 R 181.3 R 179
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- 被引次数: 0
出版历程
- 收稿日期: 2020-07-06
- 修回日期: 2020-09-01
- 网络出版日期: 2021-04-06
- 刊出日期: 2021-02-25

Pilot study on the efficacy and safety of 0.01% atropine school children with progressive myopia in Hefei

WANG Yong,
JIANG Bo

Department of Ophthalmology of Anhui NO. 2 Provincial People's Hospital, Hefei(230041), China

摘要

摘要: 目的观察0.01%阿托品滴眼液对进展性近视学龄儿童的治疗情况，为探寻有效的儿童近视防治措施提供参考。方法随机数字表法选取合肥市城区30例进展性近视学龄儿童，年龄中位数为10(7~17)岁，在每晚睡前双眼使用不含防腐剂的0.01%阿托品滴眼液进行局部治疗，12个月后对疗效和安全性进行分析，每6个月对疗效进行1次评估。其中10例患者第二只眼睛的治疗延迟1 d，以便对瞳孔扩大、调节反应、视敏度进行可控的安全性评估。结果在近视治疗效果方面，0.01%阿托品治疗12个月后，为0.43 D/年(t=8.66，P < 0.01)。在安全性方面，在10例第二只眼睛治疗延迟1 d的患者中，可观察到的副作用是诱导了1 mm的瞳孔扩大；而在调节力、视近敏度及眼压等观察中，未见明显异常。结论 0.01%阿托品滴眼液在治疗学龄儿童近视中安全有效，具有一定临床推广价值。
- 近视 /
- 阿托品 /
- 干预性研究 /
- 儿童
Abstract: Objective To investigate the clinical effict of 0.01% atropine for myopia progression in school children, and to provide a reference for probing into an effective methods of preventing myopia among children. Methods Thirty children, with a median age of 10 years (range 7-17), were given topical treatment with preservative-free 0.01% atropine eye drops in both eyes before going to bed every night, and the efficacy and safety were analyzed 12 months later. Efficacy was assessed every 6 months. In 10 children, treatment of the second eye was delayed by one day to allow for a controlled safety assessment of side effects such as dilated pupils, hypoplasia and decreased myopia. Results In terms of myopia treatment, after 12 months of treatment with 0.01% atropine, it was 0.43 D/year(t=8.66, P < 0.01). In terms of safety, in the 10 children's treatment of the second eye was delayed by one day, the measurable side effect was the induction of 1 mm pupil dilatation, and there was no other significant abnormalities were observed. Conclusion Topical low-dose (0.01%) atropine is safe and effective in school-age children, and it has certain clinical promotion value.
- Myopia /
- Atropine /
- Intervention studies /
- Child

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表 1 不同年龄儿童使用0.01%阿托品治疗前后近视进展情况比较/(x ±s, D)

Table 1. Myopic progression before and after treatment with 0.01% atropine in children of different ages/(x ±s, D)

年龄/岁	治疗前	治疗6个月后	治疗12个月后
12~17	-0.94±0.18	-0.25±0.11	-0.35±0.09
7~11	-1.28±0.38	-0.38±0.15	-0.47±0.12
t值	2.82	2.36	3.14
P值	0.01	0.03	0.00

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表 2 0.01%阿托品滴眼后不同时间眼间的调节反应、视敏度和瞳孔直径变化比较(x ±s)

Table 2. Interocular difference in the accommodative response, visual acuity and the amount of anisocoria at different time points after unilateral application of 0.01% atropine(x ±s)

调查时间	调节反应/D	视敏度/LogMAR	瞳孔直径/mm
8：00	0.00±2.99	0.00±0.06	0.87±0.64
10：00	0.40±2.67	0.00±0.07	0.48±0.33
12：00	2.00±1.83	0.01±0.03	0.46±0.40
F值	2.56	0.20	2.37
P值	0.10	0.82	0.11

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