Abstract: Objective To evaluate an effective system of training college students for first aid skills based on Western First Responder training system. Methods Totally 1 625 non-medical college students were trained based on Western First Responder training system. Class teaching and on-line teaching were applied and their first aid skills were evaluated. The differences of theoretical and practical score, passing rate were compared before and after the training. Meanwhile, the effect of covariates, including gender, grade, territoriality and difference between town and county, on training were analyzed. Results Before the training, the students' average theoretical score, practical score, passing rate of theoretical, practical score and First Responder system were(17.63±4.87), (21.72±6.08), 5.67%, 6.16% and 4.88%, respectively. After the training, the scores and the passing rate were promoted significantly, they were (61.48±14.16), (79.24±18.54), 58.71%, 63.88% and 55.57%, respectively, these differences were statistically significant(t /χ2 = 113.63, 118.89, 1 061.10, 1 025.70, 988.50, P<0.01). Gender, grade, region, and whether from town or country had no effect on the scores(P>0.05). Conclusion College students are competent for the Western First Responder training system. It was of practical significance to train college students based on standard international training system.