Abstract: Objective To investigate the related influencing factors of video display terminal (VDT) syndrome risk among college students in Xi'an, thereby providing theoretical evidence for its comprehensive prevention and treatment.Methods Totally1 491 subjects, randomly selected from Xi'an by multi-stage cluster sampling method, were surveyed in the questionnaire investigation consisting of lifestyle, dietary assessment and symptoms of VDT.Multivariate unconditional logistic regression models was used to evaluate the association between dietary patterns and VDT symptom risk.Results Among college students, the overall prevalence of VDT syndrome was 73.6%.Eye symptoms such as dry eye, eye pain, eye swelling, and vision loss (69.4%, 62.6%, 62.4%, 59.0%, 56.1%) were the highest among self-reported health problems related to VDT operations.Multivariate logistic regression analysis showed that abnormal vision, bad eating habits, poor physical status, poor VDT operation habits were significantly associated with a higher risk of VDT syndrome, the OR values (95%CI) were as follows: 1.14 (1.01, 1.29), 1.15 (1.01, 1.30), 1.51 (1.33, 1.71) and 1.18 (1.04, 1.33).In addition, the results of multivariable analysis also supported a slightly protective effect of good sleep and mental state and suitable working conditions, with the corresponding OR values (95% CI) being 0.68 (0.60, 0.77) and 0.67 (0.59, 0.76).Conclusion The prevalence of VDT syndrome is fairly high among college students.Ocular factors, dietary habits, sleep and mental state, environmental conditions, physical fitness and habit of computer usage are all involved in the development of VDT syndrome.Relevant health education should be strengthened to effectively curb the occurrence of VDT syndrome.