Abstract: Objective To explore the effect of combined intervention with deep repetitive transcranial magnetic stimulation (rTMS),injectable mouse nerve growth factor (mNGF) with treatment and education of autistic and related communication handicapped children (TEACCH) among autism spectrum disorder (ASD) children.Methods Twennty ASD children aged 3-6 years old were selected from a controlled clinical trial as the intervention group receiving TMS,mNGF and TEACCH;another 20 gender and age-matched ASD children from one public welfare institution was recruited as control group receiving only TEACCH.All of the participants were followed up for 6 months,ABC and CARS scales were assessed before and after intervention.Results After intervention,significant improvements were found in both groups in communication,body movement,language,daily self-care and total score of the ABC scale,as well as in total score of CARS scale(P<0.05).The communication,body movement,language,daily self-care and total score of ABC scale,as well as the total score of CARS scale were lower in the intervention group than control group(P<0.05).Conclusion Comprehensive rehabilitation intervention with deep repetitive transcranial magnetic stimulation(rT-MS),injectable mNGF with TEACCH could significantly improve developmental outcomes among autism child.