摘要:
了解成都市健康儿童不同流行期手足口病病毒携带情况,为手足口病防控工作提供技术支持.方法 采用分层随机抽样方法,抽取成都市120所托幼机构的758名健康托幼儿童,在手足口病发病高峰期、低谷期采用RT-PCR检测健康儿童肠道病毒类型.结果 流行期健康儿童肠道病毒阳性率为8.93%,非流行期阳性率为2.13%,差异有统计学意义(x2=17.70,P<0.01).流行期健康儿童其他肠道病毒阳性率为7.44%,高于非流行期(2.13%)(x2=12.30,P<0.01).流行期时城区健康儿童肠道病毒携带率(13.13%)高于郊区(2.89%) (x2=10.47,P=0.001);健康儿童其他肠道病毒携带率高于确诊病例(x2=28.26,P<0.01),CA16,EV71携带率低于确诊病例(P值均<0.01).结论 加强流行期城区托幼机构手足口病防控工作,积极开展手足口病健康儿童其他肠道病毒病原型别监测研究,警惕流行期健康儿童EV71携带情况,对控制手足口病流行具有重要意义.
Abstract:
Objective This study aimed to analyze the prevalence of carrier status of pathogens of Hand Foot and Mouth disease among healthy children in Chengdu kindergartens in different periods and to provide a scientific reference for developing strategies for the prevention and control of HFMD.Methods Random sampling method was used to select 758 healthy children from 120 kindergartens in Chengdu,and they were tested with real-time PCR to get the information on enteroviruses during the period of highs and lows.Results The positive rate of enterovirus in healthy children was 8.93% in epidemic period,and the positive rate was 2.13% in non-epidemic period.The positive rate in epidemic period was higher than that in non-epidemic period(x2 =17.70,P<0.01).The positive rate of other enteroviruses in epidemic period was 7.44% which was higher than that in non-epidemic period(x2 =12.30,P<0.01).The positive rate of enterovirus among healthy children in urban was higher than that in suburbs in epidemic period(x2 =10.47,P=0.001).The incidence of other enteroviruses in healthy children was higher than that in the confirmed cases (x2=28.26,P<0.01).The rates of CA16 and EV71 were lower than those in the confirmed cases(P<0.01).Conclusion In epidemic periods we should strengthen the prevention and control work of HFMD in urban,carry out pathogen surveillance on other enteroviruses,and focus on the prevalence of EV71 carrying among healthy children in Chengdu.
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