Abstract: Objective To evaluate the effect of personalized nutrition intervention on obese and wasting students,and to provide a theoretical basis for further application.Methods A total of 44 obese students and 43 wasting students from a primary school in Shanghhai were included.Students and their parents in the intervention group participated in a nine-month personalized intervention.The interventions included targeted nutrition education,follow-ups,meal-intervention,WeChat media spreading and online nutrition consttltancy.The nutrition questionnaires were conducted among all students and parents and the students' height,weight,body fat as well as skinfold thickness were examined before and after the intervention.Results Compared to the control group,students' scores of intervention group in nutrition knowledge,attitude and behavior were significantly improved by 0.66,0.96 and 1.66,respectively after the intervention(Z=-2.274,-2.850,-2.120,P<0.05).The change of BMI and body fat was not seen in the statistical way (P>0.05).The skinfold thickness of triceps and subscapular decreased in intervention group of obese students(t=-2.491,2.149,P<0.05),but increased among wasting students(t=-2.674,-2.752,P