Abstract: Objective To understand the prevalence of depression among college students in Guiyang,and possible relations with common life events,aiming to provide a reasonable reference for health education.Methods By using stratified random sampling method,1 123 college students from 5 colleges in Guiyang were selected and surveyed with questionnaires including Adolescent Self-rating Life Events Checklist and Self-rating Depression Scale.Results The detection rate of depression in Guiyang college students was 34.37%(95%CI=31.60%-37.14%).Overall score of life events among students with depression was higher than those without depression(P<0.01).Spearman rank correlation showed that depression scores positively correlated with life events scores (rs =0.325,P<0.01).Univariate analyses showed that depression was associated with professional satisfaction,parental marital status,life events and other factors(P<0.05).The non-conditional logistic regression analyses indicated that compared with students with low professional satisfaction,those with high professional satisfaction had lower risk of depression(OR=0.542).Parents' remarriage was a risk factor for depression(OR=2.313).Adverse interpersonal events(OR=1.361),health adaptation events (OR=1.653) and other adverse events(OR =1.773) were risk factors for depression.Conclusion Prevalence of depression is high in Guiyang college students.Prevention and healthy coping on adverse life events will play an important role in depression prevention among college students.