Abstract: Objective To explore the effect of "52110" intervention on healthy eating and physical exercising among primary and middle school students.Methods An questionnaire survey,physical examination and blood pressure assessment among 2 148 students selected with random cluster sampling from 7 primary and middle schools in Yinchuan and Wuzhong cities of Ningxia during September 2014.Results The awareness on healthy knowledge was relatively high at baseline in both cities.Before and after 3-month intervention,correct rate on healthy knowledge among intervention group (52.7%,69.8%) was higher than that of the control group (42.5%,64.1%) (x2 =14.036,4.965,P<0.01,P=0.026,respectively).After intervention,intervention consumed more healthy food including fruits,vegetables and meat,and spent more time in moderate intensity exercise and television watching,but less high intensity exercise than that in the control group(P<0.05).The height and weight of the intervention group was higher after intervention than before intervention,SBP was lower than that before intervention,the differences were statistically significant(P<0.01).The BMI and DBP had no significant changes before and after intervention.Higher BMI,height and weight while lower SBP among control group was found compared with before intervention(P<0.01).Conclusion The intervention model of "52110" can affect eating and physical exercising pattern,as well as effectively alleviate overweight and obesity risk among primary and middle school students.