Abstract: Objective To explore epidemical characteristics of injuries among primary and secondary school students in Guangzhou,and to provide reference for the development of injury prevention and controlling strategies.Methods We established the school injury monitoring system for primary and secondary school students in Guangzhou and analyzed the data collected from Information System for Injury Surveillance of Primary Secondary School Students in Guangzhou from 2012 to 2015.Results The injuries were mainly happened on campus (74.2%),higher than the incidence happened outside the campus (25.8%).Injuries were mainly unintentional self-injury (on campus 69.7%,outside the campus 74.5%) or unintentional injury due to someone else (on campus 27.4%,outside the campus 23.8%) inside and outside the campus.Injuries in campus were mild (60.3%),while injuries outside campus were moderate(52.0%).The causes of injuries in the campus were fall,sprain,collision/crush,cut/stab,and the constituent ratios were 38.2%,25.9%,22.7% and 9.7% respectively.And outside the campus were fall,sprains,traffic accidents,collision/crush,cut/stab,and the constituent ratios were 46.1%,13.9%,13.7%,11.7% and 5.5% respectively;The primary school students' injuries on and outside the campus occurred mainly during the playing (43.9% and 49.7%),student'injuries in junior high school,high school and vocational middle school on campus occurred mainly in sports activities (52.2%,67.4%,63.1%),Injuries outside the school are mainly cycling/riding (46.5%,29.4%,51.2%) and walking(18.6%,23.4%,19.5%).Conclusion It is important to prevent falls,sprains,collisions / crush for primary school students during playing on campus and outside the campus.Sports injury,should be mainly prevented on campus in the middle school stage,while the fall,sprain,traffic accident,and collision/crush should be prevented outside the campus.