Abstract: Objective To understand the current situation of suicide attitude among middle school students in Guizhou province and possible influencing factors based on structural equation model.Methods By using multi-stage stratified random sampiing,5 109 middle school students from 3 districts in Guizhou were investigated with self-designed suicide attitude questionnaire and self-rating depression scale.Data was analyzed by factor analysis and structural equation models using SPSS 17.0 and Amos 23.0.Results Among the 5 109 middle school students in Guizhou,proportion of students who were supportive for attempted suicidal,committed suicide,family members of suicide victim and euthanasia was 3.8% (192),36.1 (1 845),68.0% (3 475) and 20.8%(1 063),respectively.Significant differences in attitude towards suicide were found in students with different characteristics,including religious belief,residence in school,the only children,left-behind child,urbanicity,grades and regions(P<0.05).The structural equation model showed that depressive and anxiety symptoms had the greatest impact on suicidal attitudes (total effect was 0.304),followed by parental rearing style(0.237),family atmosphere(0.202),social bullying (0.187) and life education(0.095).Conclusion This results clarify the need for improving attitudes towards suicide behavior among high school students in Guizhou province.Prevention of emotional problems and positive parenting style might help prevent suicide among high school students in consideration of strong correlation between emotional problems and parenting style with suicide attitude.