延边小学生血脂体质量指数与代谢综合征的关系

李医华; 全振喜; 文海燕; 方今女

doi:10.16835/j.cnki.1000-9817.2017.07.015

延边小学生血脂体质量指数与代谢综合征的关系

doi: 10.16835/j.cnki.1000-9817.2017.07.015

延边大学附属医院,吉林延吉133002
延边大学医学院

基金项目:

国家自然科学基金

吉林省教育厅基金

详细信息

中图分类号: 34-1092/R
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出版历程
- 刊出日期: 2017-07-25

Relationship between serum free fatty acid/body mass index and metabolic syndrome among pupils in Yanbian Area

摘要

摘要: 探讨延边地区汉族和朝鲜族小学生血清游离脂肪酸(FFA)与体质量指数(BMI)对代谢综合征(MS)患病危险的关联性,为早期筛选儿童青少年MS高危人群提供依据.方法分别于2012年7月15-18日和2013年7月16-21日,在吉林省延边朝鲜族自治州选择5所小学校,采用整群抽样的方法,共抽取5 747名小学生(汉族3 736名,朝鲜族2 011名)作为研究对象,全部测量身高、体重、腰围和血压,并检测清晨空腹血清三酰甘油、高密度脂蛋白胆固醇、血糖、FFA.结果调整年龄和性别的协方差分析结果显示,汉族学生MS组和正常组FFA平均水平分别为(22.72±2.72)和(21.09±2,60) μmol/L,朝鲜族学生分别为(23.49± 1.64)和(21.95± 1.63)μmol/L;汉族学生MS组和正常组BMI平均水平分别为(25.68±3.58)和(16.98±2.89) kg/m2,朝鲜族学生分别为(23.11±3.63)和(17.86±3.05) kg/m2,汉族和朝鲜族学生MS组FFA和BMI平均水平均高于正常组学生(P值均<0.01),且不同民族学生MS患病水平均随着FFA和BMI水平的增加而增加(P值均<0.01).调整了年龄和性别因素后,Logistic回归分析显示,汉族学生FFA水平第四分位组MS患病危险是第一分位组的2,693倍,朝鲜族学生为12.132倍;汉族学生超重组和肥胖组的MS患病危险是正常组的19.646和223.666倍,朝鲜族学生分别为4.860和19.204倍.FFA>P75且BMI超重及肥胖组的汉族(OR=172.524,95%CI=60.288~493.705)和朝鲜族(OR=79.188,95%CI=35.728~ 175.513)学生MS患病危险升高,且均高于单纯FFA>P75组和BMI超重及肥胖组.结论延边地区学生FFA和BMI均与MS患病密切相关,FFA升高合并超重及肥胖学生MS患病危险性较高.FFA水平升高可以预测MS的患病危险,并且对于朝鲜族学生的预测作用强于汉族学生.
- 脂肪酸类 /
- 非酯化 /
- 人体质量指数 /
- 代谢综合征X /
- 生长和发育 /
- 学生
Abstract: Objective To understand the relationship between serum free fatty acid / body mass index and metabolic syndrome (MS),and their combination effects on the risk of suffering MS among Han and Korean pupils in Yanbian area,and to provide a reference for screening the high-risk adolescents of MS in the early stage.Methods A cluster sampling method was used to select a total of 5 747 elementary school students (2 011 of Korean-Chinese and 3 736 of Han nationality) from 5 primary schools of Yanbian area from 15-18 July,2012 to 16-21 July,2013.The data about their height,weight,circumference (WC),SBP and DBP,serum triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),glucose (FBG),free fatty acid (FFA) were collected.Results After adjustment for sex and age,the covariance analysis showed that the level of FFA in group with MS and in normal group among Han pupils was (22.72±2.72) and (21.09±2.60)iμmol/L,respectively,and those were (23.49±1.64) and (21.95± 1.63) μmol/L among Korean pupils,respectively;the levels of BMI in group with MS and in normal group were (25.68±3.58) and (16.98-±2.89) kg/m2 among Han pupils and those were (23.1 1±3.63) and (17.86±3.05) kg/m2 among Korean pupils,respectively.The levels of FFA and BMI in group with MS were higher than those in normal group(P<0.01).The prevalence of MS was progressively higher with the level of FFA and BMI (P<0.01) among Han and Korean pupils.The risk of MS in the upper quartile of FFA was 2.693 times as much as that in the lower quartile among Han pupils,and that was 12.132 times among Korean pupils;the risk of MS in overweight and obesity of BMI was 19.646 and 223.666 times as much as that in normal group among Han pupils,and that was 4.860 and 19.204 times among Korean pupils.The risk of MS was obviously increased in group with FFA≥P75 combined with overweight and obesity (Han:OR=172.524,95%CI=60.288-493.705;Korean:OR =79.188,95%CI=35.728-175.513),and that was obviously higher than that in group with FFA≥P75 combined with BMI normal and that in group with FFA